TH301 | Selective circadian clock protein CRY2 stabilizer

TH301 (450338-32-6) is an isoform-selective stabilizer of the circadian clock protein CRY2.  It dose-dependently lengthened the circadian period in Bmal1-dLuc and Per2-dLuc reporter cells. TH301 strongly enhanced rosiglitazone-dependent brown adipocyte differentiation revealing the importance of CRY-dependent regulation of energy metabolism and a possible new lead for anti-obesity therapeutics.

References/Citations for TH301

  1. Miller et al. (2020), Isoform-selective regulation of mammalian cryptochromes; Nat. Chem. Biol. 16 676
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

5 mg, 25 mg

Reviews

There are no reviews yet.

Be the first to review “TH301 | Selective circadian clock protein CRY2 stabilizer”

Your email address will not be published. Required fields are marked *

Product Inquiry

CAS:
450338-32-6
Catalog Number:
10-3909
Activity:
Selective circadian clock protein CRY2 stabilizer
Chemical Name:

1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]cyclopentanecarboxamide

Molecular Weight:
485.98
Molecular Formula:
C24H24ClN3O4S
Solubility:
Soluble in DMSO
Physical Properties:
Waxy orange solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

TH301 | Selective circadian clock protein CRY2 stabilizer

$80.00$325.00

CAS:
450338-32-6
Catalog Number:
10-3909
Activity:
Selective circadian clock protein CRY2 stabilizer
Chemical Name:

1-(4-Chlorophenyl)-N-[2,6-dihydro-2-(4-methoxyphenyl)-5,5-dioxido-4H-thieno[3,4-c]pyrazol-3-yl]cyclopentanecarboxamide

Molecular Weight:
485.98
Molecular Formula:
C24H24ClN3O4S
Solubility:
Soluble in DMSO
Physical Properties:
Waxy orange solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.