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BiochemicalTargets

Cyclic Nucleotides

Cyclic Nucleotides, such as cAMP and cGMP, play pivotal roles in metabolism, memory, vision, as well as fundamental processes like cell adhesion and division. They act as second messengers that transmit signals from the plasma membrane by binding to proteins such as certain kinases, ion channels, or transcription factors, which activate specific signaling pathways.

Adenylate cyclase activators

Forskolin | Adenylate cyclase activator

CAS:
66575-29-9
Catalog Number:
10-2073
Activity:
Adenylate cyclase activator
Chemical Name:
7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one
Molecular Weight:
410.51
Molecular Formula:
C22H34O7
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
>98%
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
Shipping Code:
RT

cAMP

RU.521 | cGAS Inhibitor

CAS:
2262452-06-0
Catalog Number:
10-4140
Activity:
cGAS Inhibitor
Chemical Name:

3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

Molecular Weight:
415.23
Molecular Formula:
C19H12Cl2N4O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to pale pink solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Dibutyryl cAMP | Cell permeable cAMP

CAS:
16980-89-5
Catalog Number:
10-2627
Activity:
Cell permeable cAMP
Chemical Name:
N6,O2′-Dibutyryl adenosine 3′,5′-cyclic monophosphate sodium salt
Alternate Name:
Bucladesine Na
Molecular Weight:
491.37
Molecular Formula:
C18H23N5O8P ∙ Na
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in water (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

ST034307 | Adenylate cyclase 1 inhibitor/analgesic activity

CAS:
133406-29-8
Catalog Number:
10-1620
Activity:
Adenylate cyclase 1 inhibitor/analgesic activity
Chemical Name:
6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one
Molecular Weight:
297.95
Molecular Formula:
C10H4Cl4O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

cGMP

Decoyinine | Inhibitor of GMP synthase

Decoyinine (2004-04-8) is a non-competitive and reversible inhibitor of GMP synthase (GMPS, IC50=17.3 µM).1  GMPS was shown to be a positive regulator of invasiveness in melanoma

RU.521 | cGAS Inhibitor

CAS:
2262452-06-0
Catalog Number:
10-4140
Activity:
cGAS Inhibitor
Chemical Name:

3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

Molecular Weight:
415.23
Molecular Formula:
C19H12Cl2N4O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to pale pink solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

YC-1 | Soluble guanylyl cyclase activator

CAS:
170632-47-0
Catalog Number:
10-1581
Activity:
Soluble guanylyl cyclase activator
Chemical Name:
3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole
Alternate Name:
Lificiguat
Molecular Weight:
304.34
Molecular Formula:
C19H16N2O2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Pink solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Guanylate cyclase activators

YC-1 | Soluble guanylyl cyclase activator

CAS:
170632-47-0
Catalog Number:
10-1581
Activity:
Soluble guanylyl cyclase activator
Chemical Name:
3-(5′-Hydroxymethyl-2′-furyl)-1-benzylindazole
Alternate Name:
Lificiguat
Molecular Weight:
304.34
Molecular Formula:
C19H16N2O2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Pink solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT

Inhibitors

Decoyinine | Inhibitor of GMP synthase

Decoyinine (2004-04-8) is a non-competitive and reversible inhibitor of GMP synthase (GMPS, IC50=17.3 µM).1  GMPS was shown to be a positive regulator of invasiveness in melanoma

ODQ | Soluble guanylyl cyclase inhibitor

CAS:
41443-28-1
Catalog Number:
10-1211
Activity:
Soluble guanylyl cyclase inhibitor
Chemical Name:
1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
Molecular Weight:
187.5
Molecular Formula:
C9H5N3O2
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

NKY-80 | Adenylate cyclase inhibitor

CAS:
299442-43-6
Catalog Number:
10-1482
Activity:
Adenylate cyclase inhibitor
Chemical Name:
2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
Molecular Weight:
229.24
Molecular Formula:
C12H11N3O2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
Gold-colored solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Phosphodiesterases

BML-288 | PDE2 inhibitor

CAS:
851-55-3
Catalog Number:
10-1319
Activity:
PDE2 inhibitor
Chemical Name:
6,7-Dihydro-5-methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-5H-furo[2,3-f]indole-7-carboxamide
Molecular Weight:
314.32
Molecular Formula:
C14H10N4O3S
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Dipyridamole | Pan-specific PDE inhibitor

CAS:
58-32-2
Catalog Number:
10-1095
Activity:
Pan-specific PDE inhibitor
Chemical Name:
2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Alternate Names:
NSC-515776
Molecular Weight:
504.63
Molecular Formula:
C24H40N8O4
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Ibudilast | Neuroinflammation inhibitor

CAS:
50847-11-5
Catalog Number:
10-2236
Activity:
Neuroinflammation inhibitor
Chemical Name:
3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine
Alternate Names:
2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridine-3-yl 1-propanone; KC-404; AV411
Molecular Weight:
230.31
Molecular Formula:
C14H18N2O
Solubility:
Soluble in DMSO (up to 25 mg/ml) or Ethanol (up to 20 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Other

EPAC 5376753 | EPAC inhibitor

Catalog Number:
10-1564
Activity:
EPAC inhibitor
Chemical Name:
5-((5-(2,4-Dichlorophenyl)furan-2-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
Molecular Weight:
367.21
Molecular Formula:
C15H8Cl2N2O3S
Solubility:
Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml)
Physical Properties:
Orange-red solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Mycophenolate mofetil | Immunomodulator

CAS:
128794-94-5
Catalog Number:
10-2086
Activity:
Immunomodulator
Chemical Name:
6-(1,3-Dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-4-hexenoic acid 2-(4-morpholinyl)ethyl ester
Molecular Weight:
433.51
Molecular Formula:
C23H31NO7
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 4 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT