Cyclic Nucleotides
Adenylate cyclase activators cAMP cGMP Guanylate cyclase activators Inhibitors Phosphodiesterases Other Cyclic Nucleotides
Showing 1–12 of 28 results
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cAMP
8-pCPT-2-O-Me-cAMP-AM | Epac activator
8-pCPT-2-O-Me-cAMP-AM (1152197-23-3) is a potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator.1 Induces RAP1 activa...$148.00 Select options -
Approved Drugs
Amiodarone HCl | Pan-specific ion channel blocker
Amiodarone HCl (19774-82-4) is a nonselective ion channel blocker. Class III antiarrhythmic.1 Induces cytochrome c release and induces apoptosis.2 ...$45.00 Select options -
Cyclic Nucleotides
BC-11-38 | PDE-11 inhibitor
A potent and selective inhibitor of phosphodiesterase PDE11 (IC50=0.28 mM).1 IC50s for PDE1-10 are greater than 100 mM. Restores the ability of p5...$90.00 – $360.00 Select options -
Cyclic Nucleotides
BML-288 | PDE2 inhibitor
BML-288 (851-55-3) is a potent and selective inhibitor of phosphodiesterase PDE2, IC50 = 40 nM. More potent than EHNA, another commonly used PDE2 i...$55.00 – $220.00 Select options -
Apoptosis
BRL-50481 | PDE7 inhibitor
BRL-50481 (433695-36-4) is a potent and selective inhibitor of phosphodiesterase-7 (PDE7), Ki=180 nM.1 Induces apoptosis in chronic lymphocytic leu...$60.00 – $240.00 Select options -
Asthma
Cilostamide | PDE3 inhibitor
Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and...$60.00 – $240.00 Select options -
Approved Drugs
Cilostazol | PDE3A inhibitor
Cilostazol (73963-72-1) is a clinically approved phosphodiesterase III (PDE3) inhibitor (IC50 = 0.2 μM) and anti-thrombotic agent. It inhibits plat...$40.00 – $88.00 Select options -
Adenosine A2A
CPI-444 | Adenosine A2A receptor antagonist
CPI-444 (1202402-40-1) is a potent (Ki = 3.54 nM) and selective adenosine A2A receptor antagonist. It blocked the induction of cAMP induced by NECA...$95.00 – $385.00 Select options -
cAMP
Dibutyryl cAMP | Cell permeable cAMP
Dibutyryl cAMP (16980-89-5) is a cell-permeable cAMP analog which mimics the effect of endogenous cAMP when applied to cells.1 Activates PKA.2,3 In...$28.00 – $85.00 Select options -
Approved Drugs
Dipyridamole | Pan-specific PDE inhibitor
Dipyridamole (58-32-2) is a phosphodiesterase inhibitor (IC50=0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively.1,2 Potent eq...$22.00 Select options -
Cyclic Nucleotides
EPAC 5376753 | EPAC inhibitor
EPAC 5376753 is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by ...$60.00 – $240.00 Select options -
Adenylate cyclase activators
Forskolin | Adenylate cyclase activator
Forskolin (66575-29-9) is a widely used adenylate cyclase activator.1 Forskolin also is a positive inotropic agent, vasodilator and induces platele...$60.00 – $120.00 Select options
