Cyclic Nucleotides

Amiodarone HCl (19774-82-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 μM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. Does not inhibit PDE8 or PDE93...

BML-288 (851-55-3) is a potent and selective inhibitor of phosphodiesterase PDE2, IC50 = 40 nM. More potent than EHNA, another commonly used PDE2 inhibitor. Displays no effect on a panel of over 80 receptors, ion channels...

Cilostamide (68550-75-4) is a selective inhibitor of phosphodiesterase-3 (PDE3). Displays limited selectivity for PDE3A versus PDE3B (IC50 = 27 and 50 nM)1,2. Blocks PKB/Akt signaling pathway downstream via inhibition of...

Dipyridamole (58-32-2) is a phosphodiesterase inhibitor (IC50=0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively.1,2 Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor Ki=8.2 nM vs. 144.8...

Forskolin (66575-29-9) is a widely used adenylate cyclase activator.1 Forskolin also is a positive inotropic agent, vasodilator and induces platelet activation among other activities.2-5 References/Citations1) Awad et al...

Phosphodiesterase inhibitor with some selectivity for PDE4 and 5. (IC50s= 53, 35, 48, 12 and 10 μM for PDE 1a, 2, 3, 4 and 5 respectively1). Acts as a cerebral vasodilator by selectively inducing a cGMP-independent...

Mycophenolic acid (24280-93-1) is an immunomodulator1 that blocks the biosynthesis of guanine nucleotides via inhibition of inosine 5'-monophosphate dehydrogenase. This in turn suppresses the production of proinflammatory...

Resveratrol (501-36-0) is a naturally occurring phenolic antioxidant. Displays antitumor and antiplatelet effects1. Activates SIRT1 and increases longevity in yeast2. Resveratrol ameliorates ageing-related phenotypes by...

RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable References/Citations1) Soderling et al. (1998), Cloning and...

ST-034307 (133406-29-8) is a novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM. Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC1.1 It was also shown to inhibit...