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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of IBMX | PDE inhibitor | CAS 28822-58-4
    IBMX (28822-58-4) is a pan-specific inhibitor of phosphodiesterases (IC50=2-50 µM). Inhibition of PDEs leads to increased concentration of intracellular cAMP which activates PKA2. IBMX does not inhibit PDE8 or PDE93...

  • ODQ | Soluble guanylyl cyclase inhibitor
    ODQ (41443-28-1) is a potent and selective inhibitor of soluble guanylyl cyclase (sGC), IC50 = 20 nM).1 ODQ acts via competition     with NO for the heme site of sGC where it binds irreversibly.2 ODQ does...

  • YC-1 | Soluble guanylyl cyclase activator
    YC-1 (170632-47-0) is a nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of rabbit platelets (IC50 = 14.6 μM).1 Induces...