Dibutyryl cAMP | Cell permeable cAMP

CAS:
16980-89-5
Catalog Number:
10-2627
Activity:
Cell permeable cAMP
Chemical Name:
N6,O2′-Dibutyryl adenosine 3′,5′-cyclic monophosphate sodium salt
Alternate Name:
Bucladesine Na
Molecular Weight:
491.37
Molecular Formula:
C18H23N5O8P ∙ Na
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in water (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

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25 mg$35.00
100 mg$100.00
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Dibutyryl cAMP (16980-89-5) is a cell-permeable cAMP analog which mimics the effect of endogenous cAMP when applied to cells.1 Activates PKA.2,3 Induces morphological differentiation of astrocytes.4 Promotes differentiation of dopaminergic neurons from hPSCs (in cocktails with other agents).5

References/Citations:

1) Bartsch et al. (2003), Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem., 384 1321
2) Carranza et al. (1998), Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol., 15 511
3) Hei et al. (1991), Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol., 39 233
4) Imamura et al. (1998), Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA, 95 6139
5) Xia et al. (2016), Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep., 6 20270

CAS:
16980-89-5
Catalog Number:
10-2627
Activity:
Cell permeable cAMP
Chemical Name:
N6,O2′-Dibutyryl adenosine 3′,5′-cyclic monophosphate sodium salt
Alternate Name:
Bucladesine Na
Molecular Weight:
491.37
Molecular Formula:
C18H23N5O8P ∙ Na
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in water (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

Dibutyryl cAMP (16980-89-5) is a cell-permeable cAMP analog which mimics the effect of endogenous cAMP when applied to cells.1 Activates PKA.2,3 Induces morphological differentiation of astrocytes.4 Promotes differentiation of dopaminergic neurons from hPSCs (in cocktails with other agents).5

References/Citations:

1) Bartsch et al. (2003), Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem., 384 1321
2) Carranza et al. (1998), Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol., 15 511
3) Hei et al. (1991), Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol., 39 233
4) Imamura et al. (1998), Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA, 95 6139
5) Xia et al. (2016), Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep., 6 20270

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

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