Phosphodiesterases

Phosphodiesterases (PDEs) hydrolyze phosphodiester bonds, most often in the cyclic nucleotides cAMP and cGMP. In doing so, they mediate the many signaling pathways that utilize these second messengers. They comprise a family of enzymes expressed in many different tissue types, and are involved in neurological, pulmonary, and vascular diseases, among others.

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cAMP-SELECTIVE

Roflumilast | PDE4 inhibitor

CAS:

162401-32-3

Catalog Number:

10-2657

Activity:

PDE4 inhibitor

Chemical Name:

3(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-benzamide

Alternate Names:

BYK-20869

Molecular Weight:

403.21

Molecular Formula:

C₁₇H₁₄N₂Cl₂F₂O₃

Solubility:

Soluble in DMSO (up to 25 mg/ml)

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

BRL-50481 | PDE7 inhibitor

CAS:

433695-36-4

Catalog Number:

10-1300

Activity:

PDE7 inhibitor

Chemical Name:

3-(N,N-Dimethylsulfonamido)-4-methylnitrobenzene

Molecular Weight:

244.27

Molecular Formula:

C₉H₁₂N₂O₄

Solubility:

Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).

Physical Properties:

Off-white solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Shipping Code:

Rolipram | PDE4 inhibitor

CAS:

61413-54-5

Catalog Number:

10-1079

Activity:

PDE4 inhibitor

Alternate Names:

ZK 62711

Chemical Name:

4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone (racemic)

Molecular Weight:

275.35

Molecular Formula:

C₁₆H₂₁NO₃

Solubility:

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Physical Properties:

White or off-white solid

Purity:

98% by TLC
NMR conforms

Storage Temperature:

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:

cGMP-SELECTIVE

EHNA HCl | PDE2 inhibitor

CAS:

51350-19-7

Catalog Number:

10-2438

Activity:

PDE2 inhibitor

Chemical Names:

Erythro-9-(2-hydroxy-3-nonyl)adenine, hydrochloride; NSC 263164

Molecular Weight:

318.87

Molecular Formula:

C₁₄H₂₈N₅O ∙ HCl

Solubility:

Soluble in Water (up to 25 mg/ml)

Physical Properties:

Pale yellow or off-white solid

Purity:

98% HPLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 2 years as supplied. Solutions in distilled water may be stored at -20°C for up to 3 months.

Shipping Code:

Sildenafil citrate | PDE5 inhibitor

CAS:

171599-83-0

Catalog Number:

10-1221

Activity:

PDE5 inhibitor

Chemical Names:

1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate; UK-92480

Molecular Weight:

666.70

Molecular Formula:

C₂₂H₃₀N₆O₄S • C₆H₈O₇

Solubility:

Soluble in DMSO (up to 60 mg/ml)

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Sulindac Sulfide | NFkappaB inhibitor

CAS:

32004-67-4

Catalog Number:

10-2156

Activity:

NFkappaB inhibitor

Chemical Name:

(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid

Molecular Weight:

340.42

Molecular Formula:

C₂₀H₁₇FO₂S

Solubility:

Soluble in DMSO (up to 25 mg/ml).

Physical Properties:

Yellow solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Dual

Anagrelide HCl | PDE3 inhibitor

CAS:

58579-51-4

Catalog Number:

10-1220

Activity:

PDE3 inhibitor

Chemical Name:

6,7-dichloro-1,5-dihydroimidazo[2,1 –b]quinazolin-2(3H)-one hydrochloride

Alternate Names:

BL-4162A

Molecular Weight:

292.55

Molecular Formula:

C₁₀H₇Cl₂N₃O • HCl

Solubility:

Soluble in DMSO (up to 2.5 mg/ml)

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

BML-288 | PDE2 inhibitor

CAS:

851-55-3

Catalog Number:

10-1319

Activity:

PDE2 inhibitor

Chemical Name:

6,7-Dihydro-5-methyl-6-oxo-N-(1,3,4-thiadiazol-2-yl)-5H-furo[2,3-f]indole-7-carboxamide

Molecular Weight:

314.32

Molecular Formula:

C₁₄H₁₀N₄O₃S

Solubility:

Soluble in DMSO (up to 25 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Dipyridamole | Pan-specific PDE inhibitor

CAS:

58-32-2

Catalog Number:

10-1095

Activity:

Pan-specific PDE inhibitor

Chemical Name:

2,6-bis(Diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine

Alternate Names:

NSC-515776

Molecular Weight:

504.63

Molecular Formula:

C₂₄H₄₀N₈O₄

Solubility:

Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 5 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:

Phosphodiesterases

cAMP-SELECTIVE

Roflumilast | PDE4 inhibitor

BRL-50481 | PDE7 inhibitor

Rolipram | PDE4 inhibitor

cGMP-SELECTIVE

EHNA HCl | PDE2 inhibitor

Sildenafil citrate | PDE5 inhibitor

Sulindac Sulfide | NFkappaB inhibitor

Dual

Anagrelide HCl | PDE3 inhibitor

BML-288 | PDE2 inhibitor

Dipyridamole | Pan-specific PDE inhibitor

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21

Phosphodiesterases

cAMP-SELECTIVE

cGMP-SELECTIVE

Dual

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

Focus Biomolecules Plymouth Meeting, PA USA1-855-FOCUS21

Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21