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  • BTB-1 | Mitotic kinesin Kif18A inhibitor
    BTB-1 (86030-08-2) is a selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 μM.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of K-858 | Kinesin Eg5 inhibitor | CAS 72926-24-0
    K858 (72926-24-0) is a selective mitotic kinesin Eg5 inhibitor (IC50 = 1.3 μM) which acts in an ATP-noncompetitive manner1,2. It is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily...

  • Focus Biomolecules supplier, chemical structure of Monastrol | Kinesin Eg5 and mitosis inhibitor | CAS 254753-54-3
    Monastrol (254753-54-3) is a potent, cell-permeable, small molecule inhibitor of mitosis. Monastrol-arrested cells are characterized by monopolar spindles.1 Does not affect other motor proteins or tubulin. Specifically...

  • Focus Biomolecules cell signaling reagent supplier, structure S-Trityl-cysteine | Kinesin Eg5 inhibitor | CAS 2799-07-7
    S-Trityl-cysteine (2799-07-7) is a cell permeable inhibitor of mitotic kinesin Eg5 (IC50 for inhibition of basal ATPase activity = 1 μM; IC50 for inhibition of microtubule-activated ATPase activity = 140 nM). Mean growth...