AR-A 014418 | GSK-3 inhibitor

AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable. Active in rodent models.

References/Citations
1) Bhat et al. (2003), Structural insights and biological effects of glycongen synthase kinase 3-specific inhibitor AR-A014418; J. Biol. Chem., 278 45937
2) Ramirez et al. (2010), Inhibition of glycogen synthase kinase 3beta (GSK3β) decreases inflammatory responses in brain endothelial cells; Am. J. Pathol., 176 881

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

5 mg, 25 mg

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CAS:
487021-52-3
Catalog Number:
10-1195
Activity:
GSK-3 inhibitor
Chemical Name:
N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea
Molecular Weight:
308.32
Molecular Formula:
C12H12N4O4S
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

AR-A 014418 | GSK-3 inhibitor

$65.00$260.00

CAS:
487021-52-3
Catalog Number:
10-1195
Activity:
GSK-3 inhibitor
Chemical Name:
N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea
Molecular Weight:
308.32
Molecular Formula:
C12H12N4O4S
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
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