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GSK-3

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  • 6BIO | 667463-62-9 | Structure | Supplier
    6BIO | GSK-3 inhibitor
    $65.00
    6BIO (667463-62-9) is a potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM.1 The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells...

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  • Alsterpaullone | 237430-03-4 | Structure | Supplier
    Alsterpaullone | GSK3b inhibitor and CDK5/p25 inhibitor
    $56.00
    Alsterpaullone (237430-03-4) is a potent and selective inhibitor of GSK-3β and CDK5/p25. Potent inhibitor of CDK1/cyclin B (IC50 = 35 nM)1. Alsterpaullone induces apoptosis2 and inhibits angiogenesis3...

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  • AR-A 014418 | 487021-52-3 | Structure | Supplier
    AR-A 014418 | GSK-3 inhibitor
    $65.00
    AR-A 014418 (487021-52-3) is a selective glycogen synthase kinase 3 (GSK-3) inhibitor, IC50 = 104 nM. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices. Anti-inflammatory activity. Cell permeable...

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  • CHIR-99021 potent and selective inhibitor
    CHIR-99021 | GSK3 beta inhibitor
    $70.00
    CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits...

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  • GF-109203X | 133052-90-1 | Structure | Supplier
    GF-109203X | PKC inhibitor
    $80.00
    GF-109203X (133052-90-1) is a potent and selective protein kinase C inhibitor (IC50 = 10 nM; cAMP-dependent protein kinase IC50 = 2 μM and phosphorylase kinase IC50 = 0.7 μM). Inactive against the tyrosine kinases...

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  • Indirubin-3'-monoxime | 160807-49-8 | Structure | Supplier
    Indirubin-3'-monoxime | GSK-3 beta and CDK inhibitor
    $60.00
    Indirubin-3'-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase...

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  • SB-216763 | GSK-3 inhibitor
    SB-216763 | GSK-3 inhibitor
    $50.00
    SB-216763 (280744-09-4) is a potent and selective inhibitor of glycogen synthase kinase-1 (GSK-3) IC50=34.3 nM1. Acts at the ATP-binding domain. Displays protective effects in lung fibrosis mouse model2. Displays...

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