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Insulin

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  • Focus Biomolecules reagent supplier, chemical structure of 8-pCPT-2-O-Me-cAMP-AM | Epac activator | CAS 1152197-23-3
    $148.00
    8-pCPT-2-O-Me-cAMP-AM (1152197-23-3) is a potent, cell-permeable Epac (exchange protein directly activated by cAMP) activator.1 Induces RAP1 activation and insulin secretion in pancreatic beta cell lines...

  • Alpha-Mangostin | STING agonist (human)
    $50.00
    α-Mangostin (6147-11-1) is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates...

  • Focus Biomolecules supplier, chemical structure of Amlexanox | TBK1 inhibitor / Antidiabetic | CAS 68302-57-8
    $40.00
    Amlexanox (68302-57-8) improves obesity-related metabolic dysfunction in mouse models.1 Increases thermogenesis and weight loss, decreases steatosis and improves insulin sensitivity.  Inhibits TANK-binding kinase 1...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Azoramide | UPR modulator | CAS 932986-18-0
    $50.00
    Azoramide (932986-18-0) is a modulator of the unfolded protein response (UPR).1  It improves endoplasmic reticulum (ER) protein folding and activates ER chaperone capacity to protect cells against ER stress. It...

  • Focus Biomolecules supplier, chemical structure of BRD-7389 | p90 RSK inhibitor: insulin stimulator | CAS 376382-11-5
    $80.00
    BRD-7389 (376382-11-5) inhibits p90 ribosomal S6 kinase (RSK), IC50 = 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively.1 Induces a β-cell-like state in pancreatic α-cells and induces insulin...

  • Focus Biomolecules supplier, chemical structure of Cerulenin | Fatty Acid Synthase inhibitor | CAS 17397-89-6
    $90.00
    Cerulenin (17397-89-6) is a fatty acid synthase (FAS) inhibitor. Binds to β-keto-acyl-ACP synthase (KAS; IC50=1.5 μM), thus inhibiting protein acylation at concentrations of 45-134 μM.1 Cerulenin produces...

  • Focus Biomolecules supplier, chemical structure of CL-316243 | beta 3-adrenergic agonist / antiobesity | CAS 151126-84-0
    $80.00
    CL-316243 (151126-84-0) is a potent and selective β-3 adrenergic receptor agonist. (EC50= 3 nM) Displays anti-obesity and anti-diabetic effects in mice. It increases brown fat thermogenesis and metabolic rate and...

  • Focus Biomolecules supplier, chemical structure of Efaroxan HCl | alpha 2 adrenergic antagonist | CAS 89197-00-2
    $80.00
    Efaroxan HCl (89197-00-2) is a selective α2-adrenergic receptor antagonist1 (selectivity ratio of α2/α1 = 724)4 and imidazoline receptor antagonist2. Induces release of insulin in the rat insulinoma cell...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of FSG67 | GPAT inhibitor | CAS 1158383-34-6
    $55.00
    FSG67 (1158383-34-6) is an inhibitor of Glycerol 3-Phosphate Acyltransferase (GPAT); IC50 = 24 μM.1 It was able to reduce food intake, decrease body weight and adiposity, enhance energy utilization as fatty acid...

  • Focus Biomolecules cell signaling reagent supplier, structure of Glyburide | K-ATP channel blocker | CAS 10238-21-8
    $30.00
    Glyburide (10238-21-8) is a second generation oral hypoglycemic agent. Acts via ATP-dependent K+ channel (Kir6, KATP) block.1 Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GSK-137647 | GPR120 agonist | CAS 349085-82-1
    $90.00
    GSK-137647 (349085-82-1) is a potent and selective agonist at free fatty acid receptor 4 (FFA4), also known as GPR120. pEC50s= 6.3, 6.2 and 6.1 for human, mouse and rat receptor respectively1. GSK-137647 enhances...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW1100 | GPR40 antagonist | CAS 305974-70-9
    $60.00
    GW1100 (305974-70-9) is a selective antagonist of GPR40. GW1100 inhibits GRP40-mediated Ca2+ increases stimulated GW9508 (Cat.# 10-1108) or linoleic acid (pIC50 = 5.99 for either agonist).1 The effects of GPR40 activation on...

  • Focus Biomolecules supplier, chemical structure of ISX9 | Neurogenic differentiation inducer | CAS 832115-62-5
    $70.00
    ISX9 (832115-62-5) promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory.1 Induces robust neuronal differentiation in adult neural...

  • KY-226 | PTP1B inhibitor
    $65.00
    KY-226 (CAS 1621673-53-7)  is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50 = 250 nM) with no activity at PPARγ.1 It significantly reduced plasma glucose, triglyceride, and A1c...

  • Obeticholic Acid | FXR agonist
    $50.00
    Obeticholic acid (459789-99-2) is a novel cholic acid analog which acts as a potent and selective FXR agonist (EC50= 99 nM). Displays anticholeretic activity in a rat model of cholestasis.1 Promotes adipocyte differentiation...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Oltipraz | Nrf2 activator | CAS 64224-21-1
    $39.00
    Oltipraz (64224-21-1) upregulates the transcription factor NRF2 and prevents insulin resistance and obesity induced by high fat diet in C57BL/6J mice1. Attenuates the progression of fibrosis in a rat model of nonalcoholic...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Teprenone | HSP70 inducer | CAS 6809-52-5
    $50.00
    Teprenone (6809-52-5) induces expression of HSP70 after various types of stimuli.1,2 Protects against visceral adipocity and insulin resistance in high fat fed mice.3 Teprenone displays protective effects via enhanced...

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