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Diabetes

Diabetes is a disease characterized by either the inability to produce enough insulin or a lack of cellular response to insulin. The resulting high blood sugar levels lead to myriad health issues including cardiovascular disease, vision loss, nerve damage, and kidney disease. Current therapies for glycemic control include metformin, sulfonylureas and PPAR-γ agonists. Newer modalities targeting the incretin axis include dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon-like peptide-1 (GLP-1) agonists. A novel method for controlling glucose via the kidneys is inhibition of sodium glucose co-transporter 2 (SGLT2).

Adipogenesis

Belumosudil | ROCK2 Inhibitor

CAS:
911417-87-3
Catalog Number:
10-4165
Activity:
Selective Rho kinase 2 (ROCK2) inhibitor
Chemical Names:
2-[3-[4-(1H-Indazol-5-yl)amino)quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide; KD025; SLx-2119
Molecular Weight:
452.52
Molecular Formula:
C26H24N6O2
Solubility:
Soluble in DMSO (25 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied from date of purchase. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Formononetin | PPARgamma activator; increases adipocyte thermogenesis

CAS:
485-72-3
Catalog Number:
10-2252
Activity:
PPARγ activator; increases adipocyte thermogenesis
Chemical Name:
7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
Alternate Name:
7-Hydroxy-4′-methoxyisoflavone; Biochanin B; Neochanin; NSC 93360; Formononetol
Molecular Weight:
268.26
Molecular Formula:
C16H12O4
Solubility:
Soluble in DMSO (up to 100 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Obeticholic Acid | FXR agonist

CAS:
459789-99-2
Catalog Number:
10-2838
Activity:
FXR agonist
Chemical Name:
3α-7α-dihydroxy-6α-ethyl-5ß-cholan-24-oic acid
Alternate Names:
6-Ethylchenodeoxycholic acid; 6-ECDCA
Molecular Weight:
420.63
Molecular Formula:
C26H44O4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Adiponectin

Miglitol | beta-glucosidase inhibitor / antidiabetic

CAS:
72432-03-2
Catalog Number:
10-2332
Activity:
α-glucosidase inhibitor / antidiabetic
Alternate Names:
N-(2-Hydroxyethyl)-1-deoxynojirimycin; BAY-1099
Chemical Name:
(2R,3R,4R,5S)-1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
Molecular Weight:
207.23
Molecular Formula:
C8H17NO5
Solubility:
Soluble in DMSO (up to 50 mg/ml with warming), or in Water (up to 60 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

AdipoRon | Adiponectin agonist

CAS:
924416-43-3
Catalog Number:
10-1483
Activity:
Adiponection agonist
Chemical Name:
2-(4-Benzylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide
Molecular Weight:
428.54
Molecular Formula:
C27H28N2O3
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

Aldose reductase

Epalrestat | Aldose reductase inhibitor

CAS:
82159-09-9
Catalog Number:
10-4423
Activity:
Aldose reductase inhibitor
Alternate Names:
ONO-2235
Chemical Name:
2-[(5Z)-5-[(E)-3-Phenyl-2-methylprop-2-enylidene]- 4-oxo-2-thioxo-3-thiazolidinyl]acetic acid
Molecular Weight:
319.4
Molecular Formula:
C15H13NO3S2
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
Yellow solid
Purity:
>98% by TLC
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT

AMPK

Cordycepin | AMPK activator

CAS:
73-03-0
Catalog Number:
10-2408
Activity:
AMPK activator
Chemical Name:
3’-Deoxyadenosine
Alternate Name:
NSC 63984
Molecular Weight:
251.24
Molecular Formula:
C10H13N5O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% byHPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Punicalagin | Anti-inflammatory

CAS:
65995-63-3
Catalog Number:
10-4583
Activity:
Anti-inflammatory / antioxidant / anti-tumor agent
Molecular Weight:
1084.72
Molecular Formula:
C48H28O30
Solubility:
Soluble in Water (greater than 20 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
Shipping Code:
RT

Metformin HCl | Anti-diabetic agent

CAS:
1115-70-4
Catalog Number:
10-2469
Activity:
Anti-diabetic agent
Chemical Name:
1,1-Dimethylbiguanide hydrochloride
Molecular Weight:
165.63
Molecular Formula:
C4H11N5 HCl
Solubility:
Soluble in DMSO (up to 8 mg/ml) or in Water (up to 16 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 2 months.
Shipping Code:
RT

DPP4

Mirabegron | beta-3 Adrenergic agonist

Mirabegron (223673-61-8) is a potent (EC50 = 22.4 nM CHO cells expressing human ß3-ARs) beta-3 adrenergic receptor (ß3-AR) agonist with high selectivity over the beta-1 and

TPPU | Soluble epoxide hydrolase inhibitor

TPPU (1222780-33-7) is a potent and selective inhibitor of both murine and human soluble epoxide hydrolase, IC50=2.8 and 3.7 nM respectively.1 It alleviated blood brain barrier

BI01383298 | Citrate transporter inhibitor

BI01383298 (2227549-00-8) is a potent, non-competitive, irreversible inhibitor of the human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY).1,2  IC50 = 49 nM in the presence of Li+ with preincubation

Glucose metabolism

Mirabegron | beta-3 Adrenergic agonist

Mirabegron (223673-61-8) is a potent (EC50 = 22.4 nM CHO cells expressing human ß3-ARs) beta-3 adrenergic receptor (ß3-AR) agonist with high selectivity over the beta-1 and

Canagliflozin | SGLT2 inhibitor

CAS:
842133-18-0
Catalog Number:
10-3576
Activity:
SGLT2 inhibitor
Chemical Names:
(1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol;
JNJ-24831754
Molecular Weight:
444.52
Molecular Formula:
C24H25FO5S
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

BMS-309403 | FABP4 inhibitor

CAS:
300657-03-8
Catalog Number:
10-4762
Activity:
FABP4 inhibitor
Chemical Name:
2-[3-[2-(5-Ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid
Molecular Weight:
474.55
Molecular Formula:
C31H26N2O3
Solubility:
Soluble in DMSO (up to at lease 25 mg/ml).
Physical Properties:
Off-white or pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

GPCRs

Efaroxan HCl | α2 adrenergic antagonist

CAS:
89197-00-2
Catalog Number:
10-1342
Activity:
α2 adrenergic antagonist
Alternate Names:
RX 821037A
Chemical Name:
2-Ethyl-2-(imidazolin-2-yl)-2,3-dihydrobenzofuran, hydrochloride
Molecular Weight:
252.74
Molecular Formula:
C13H16N2O HCl
Solubility:
Soluble in Water (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

GSK-3

6BIO | GSK-3 inhibitor

CAS:
667463-62-9
Catalog Number:
10-1400
Activity:
GSK-3 inhibitor
Chemical Name:
(2’Z,3’E)-6-Bromoindirubin-3’oxime
Molecular Weight:
356.18
Molecular Formula:
C16H10BrN3O2
Solubility:
Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 4 mg/ml with warming).
Physical Properties:
Purple solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT

CHIR-99021 | GSK3ß inhibitor

CAS:
252917-06-9
Catalog Number:
10-1279
Activity:
GSK3β inhibitor
Chemical Name:
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Molecular Weight:
465.35
Molecular Formula:
C22H18Cl2N8
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Tan solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

AR-A 014418 | GSK-3 inhibitor

CAS:
487021-52-3
Catalog Number:
10-1195
Activity:
GSK-3 inhibitor
Chemical Name:
N-[(4-Methoxyphenyl)methyl]-N’-(5-nitro-2-thiazolyl)urea
Molecular Weight:
308.32
Molecular Formula:
C12H12N4O4S
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Insulin receptor

BGP-15 | Cellular protectant

CAS:
66611-37-8
Catalog Number:
10-1373
Activity:
Cellular protectant
Chemical Names:
N-[2-Hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
Molecular Weight:
351.28
Molecular Formula:
C14H22N4O2·2HCl
Solubility:
Soluble in Water (70 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at room temperature for up to 1 month.
Shipping Code:
RT

GSK2656157 | PERK inhibitor

CAS:
1337532-29-2
Catalog Number:
10-4855
Activity:
PERK inhibitor
Chemical Names:
1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanone
Molecular Weight:
416.45
Molecular Formula:
C23H21FN6O
Solubility:
Soluble in DMSO (10 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

AS-1949490 | SHIP2 inhibitor

CAS:
1203680-76-5
Catalog Number:
10-5103
Activity:
SHIP2 inhibitor
Chemical Names:
3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]- 2-thiophenecarboxamide
Molecular Weight:
371.88
Molecular Formula:
C20H18ClNO2S
Solubility:
Soluble in DMSO (40 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 month.
Shipping Code:
RT

PPAR

Elafibranor | PPARalpha/delta agonist

CAS:
923978-27-2
Catalog Number:
10-3901
Activity:
PPARalpha/delta agonist
Chemical Name:
2-[2,6-Dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acid
Alternate Name:
GFT505
Molecular Weight:
384.49
Molecular Formula:
C22H24O4S
Solubility:
Soluble in DMSO (up to at least 25 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Oleoylethanolamide | GPR119 agonist: stimulates lipolysis

CAS:
111-58-0
Catalog Number:
10-1475
Activity:
GPR119 agonist: Stimulates lipolysis
Chemical Name:
N-(2-Hydroxyethyl)-9Z-octadecenamide
Alternate Names:
OEA
Molecular Weight:
325.53
Molecular Formula:
C20H39NO2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

GW-501516 | PPAR delta agonist

CAS:
317318-70-0
Catalog Number:
10-1542
Activity:
PPAR delta agonist
Chemical Name:
2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazoyl]methyl]thio]phenoxy]acetic acid
Molecular Weight:
453.50
Molecular Formula:
C21H18F3NO3S2
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

PTP-1B

KY-226 | PTP1B inhibitor

CAS:
1621673-53-7
Catalog Number:
10-4004
Activity:
PTP1B Inhibitor
Chemical Name:
4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide
Molecular Weight:
481.67
Molecular Formula:
C27H31NO3S2
Solubility:
Soluble in DMSO (>25 mg/ml).
Physical Properties:
Off-white solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Other Diabetes

Mirabegron | beta-3 Adrenergic agonist

Mirabegron (223673-61-8) is a potent (EC50 = 22.4 nM CHO cells expressing human ß3-ARs) beta-3 adrenergic receptor (ß3-AR) agonist with high selectivity over the beta-1 and

TPPU | Soluble epoxide hydrolase inhibitor

TPPU (1222780-33-7) is a potent and selective inhibitor of both murine and human soluble epoxide hydrolase, IC50=2.8 and 3.7 nM respectively.1 It alleviated blood brain barrier

BI01383298 | Citrate transporter inhibitor

BI01383298 (2227549-00-8) is a potent, non-competitive, irreversible inhibitor of the human Na+-coupled citrate transporter (NaCT/SLC13A5/mINDY).1,2  IC50 = 49 nM in the presence of Li+ with preincubation