Disease Model Inducers

In addition to exploring signaling pathways, small molecules are also used as a means to an end: to create a cell or animal model system for further research or drug screening. Focus Biomolecules offers small molecule tools to induce model systems such as: Streptozotocin (diabetes, Alzheimer’s); Kainic acid (neurodegeneration); Bleomycin sulfate (pulmonary fibrosis); and many others to create cancer or stem cell models.

Home >> Physiological Processes >> Disease Model Inducers

Antimycin A | Mitochondrial Complex III inhibitor

Antimycin A (1397-94-0) is a mitochondrial electron transport inhibitor at complex III. Induces apoptosis in various cell lines.1 Antimycin A may be used to generate cellular models […]

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Bleomycin sulfate | Induces double strand DNA breaks

CAS:

9041-93-4

Catalog Number:

10-2623

Activity:

Fibrosis-inducing agent

Source:

From Streptomyces verticillus

Molecular Weight:

1512.62

Molecular Formula:

C₅₅H₈₅N₁₇O₂₅S₄

Solubility:

Soluble in Water (up to 20 mg/ml)

Physical Properties:

White or off-white solid

Purity:

Contains a mixture of A₂ (~70%) and B₂ (~30%) forms

95% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from the date of purchase. Solutions in distilled water may be stored at -20°C for up to 3 months.

Shipping Code:

RT

From $75.00
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Conduritol B epoxide | Glycosidase inhibitor

CAS:

6090-95-5

Catalog Number:

10-1172

Activity:

β-Glycosidase inhibitor

Alternate Names:

CBE

Chemical Name:

D,L-1,2-Anhydro-myo-inositol

Molecular Weight:

162.14

Molecular Formula:

C₆H₁₀O₅

Solubility:

Soluble in Water (up to 25 mg/ml) or in DMSO

Physical Properties:

White solid

Purity:

98% by TLC

NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Compound is hygroscopic, protect from moisture. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.

Shipping Code:

RT

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Cyclothiazide | AMPA receptor positive allosteric modulator

CAS:

2259-96-3

Catalog Number:

10-2449

Activity:

AMPA receptor positiv e allosteric modulator

Chemical Name:

6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide

Alternate Names:

LY-35483

Molecular Weight:

389.88

Molecular Formula:

C₁₄H₁₆ClN₃O₄S₂

Solubility:

Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 9 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

RT

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:

RT

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Ibotenic acid | NMDA and mGluR agonist

CAS:

2552-55-8

Catalog Number:

10-2693

Activity:

NMDA and mGluR agonist

Chemical Name:

α-Amino-3-hydroxy-5-isoxazoleacetic acid hydrate

Molecular Weight:

176.13

Molecular Formula:

C₅H₆N₂O₄ • H₂O

Solubility:

Soluble in Water (up to 1 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.

Shipping Code:

RT

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Kainic acid | Kainate receptor agonist/neurotoxin

CAS:

487-79-6

Catalog Number:

10-2453

Activity:

Kainate receptor agonist; neurotoxin

Chemical Name:

(2S,3S,4S)-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid, hydrate

Molecular Weight:

213.24

Molecular Formula:

C₁₀H₁₅NO₄ (xH₂O)

Solubility:

Soluble in Water (up to 10 mg/ml).

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

RT

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.

Shipping Code:

RT

From $120.00
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