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Disease Model Inducers

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  • Focus Biomolecules supplier, chemical structure of Bleomycin sulfate | Induces double strand DNA breaks | CAS 9041-93-4
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal...

  • Focus Biomolecules cell signaling supplier, chemical structure of Ibotenic acid | NMDA & mGluR agonist | CAS 2552-55-8
    Ibotenic acid (60573-88-8) is a conformationally restricted analog of glutamate which occurs naturally in Amanita mascaria and related mushrooms.  It is a non-specific glutamate receptor (both NMDA and mGluR) agonist.1...

  • Focus Biomolecules cell signaling supplier, chemical structure of Monocrotaline | Induces pulmonary fibrosis | CAS 315-22-0
    Monocrotaline (315-22-0) is a naturally occurring pyrrolizidine alkaloid used to create an animal model of pulmonary arterial hypertension (PAH). It can mimic several important aspects of human PAH including vascular...

  • Focus Biomolecules supplier, chemical structure of Puromycin Aminonucleoside | Nephropathy inducer | CAS 58-60-6
    Puromycin aminonucleoside (58-60-6) is the nucleoside moiety of puromycin (Cat.# 10-2100) which does not inhibit protein synthesis or induce apoptosis1. It acts as a glomerular epithelial cell toxin2 and as such is a useful...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Streptozotocin | Diabetes inducer | CAS 18883-66-4
    Streptozotocin (18883-66-4) is an N-nitroso-aminoglucose derivative which is used to produce animal models of diabetes.1 Alkylates DNA.2 Inhibits pancreatic β-cell O-Glc-NAc selective N-acetyl-β-D-glucosaminidase...

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