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DNA Damage

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  • Focus Biomolecules cell signaling reagent supplier, structure of 3-Aminobenzamide | PARP inhibitor | CAS 3544-24-9
    3-Aminobenzamide (3544-24-9) inhibits endogenous poly-ADP-ribosyltransferases1. Inhibits nitric oxide-induced apoptosis but not differentiation in HL-60 cells2. Inhibits stress-induced apoptosis3. 3-Aminobenzamide has been...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 4-HQN | PARP inhibitor | CAS 491-36-1
    4-HQN (491-36-1) is an inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM).1 Displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent...

  • Focus Biomolecules cell signaling tech supplier, structure 5-Fluorouracil | Inhibitor of thymidylate synthase | CAS 51-21-8
    5-Fluorouracil (51-21-8) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-Fluorouracil are 5-Fluorodeoxyuridylate (5-FdUMP),...

  • Focus Biomolecules supplier, chemical structure of 6-Thioguanine | Anticancer agent | Downregulates DNMT1 | CAS 154-42-7
    6-Thioguanine (154-42-7) is a methyltransferase inhibitor.  After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It...

  • Focus Biomolecules supplier, chemical structure of 8-Oxo-2'-deoxyguanosine | Marker for DNA damage | CAS 88847-89-6
    8-Oxo-2'-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes1. It is a critical biomarker for oxidative stress and carcinogenesis2,3. References/Citations1) Beckman et al...

  • A-196 | SUV420H1/H2 methyltransferase inhibitor
    A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited...

  • Focus Biomolecules cell signaling reagent supplier, structure of Apigenin | Protein kinase inhibitor | CAS 520-36-5
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

  • AZ20  | ATR kinase inhibitor
    AZ20 (1233339-22-4) is a potent and highly selective inhibitor of Ataxia telangiectasia mutated and RAD3-related (ATR) kinase (IC50 = 5 nM in vitro; IC50 = 50 nM in HT29 colorectal adenocarcinoma cells).1 Combination therapy...

  • AZD7762 | Checkpoint kinase 1/2 inhibitor
    AZD7762 (860352-01-8, free base) is a potent and selective inhibitor of checkpoint kinases 1 and 2 (IC50 = 5 nM for both).1 It abrogates DNA damage-induced S and G2 checkpoints and enhances the efficacy of DNA damaging...

  • beta-Lapachone | Topoisomerase I inhibitor
    β-Lapachone (4707-32-8) is a naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable...

  • Focus Biomolecules supplier, chemical structure of Bleomycin sulfate | Induces double strand DNA breaks | CAS 9041-93-4
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Induces double-strand DNA damage.3 Commonly used to induce lung fibrosis in animal...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML-277 | CHK2 inhibitor | CAS 516480-79-8
    BML-277 (516480-79-8) is a potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 μM, demonstrating the...

  • Focus Biomolecules cell signaling reagent supplier, structure of Camptothecin | Topoisomerase I inhibitor | CAS 7689-03-4
    Camptothecin (7689-03-4) is a natural product isolated from the Chinese Happy Tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I. Camptothecin binds irreversibly to the topoisomerase I /DNA complex...

  • Focus Biomolecules cell signaling reagent supplier, structure of Cantharidin | Phosphatase PP2A inhibitor | CAS 56-25-7
    Cantharidin (56-25-7) inhibits protein phosphatase 2A (Ki=0.19 μM) and PP1 (Ki=1.1 μM)1. Displays >500-fold selectivity over PP2B. Suppresses growth and migration of PANC-1 pancreatic cancer cells via...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cisplatin | Anticancer agent | CAS 15663-27-1
    Induces intra- and interstrand DNA adducts which poison topoisomerase I.1 Synergizes with topoisomerase I inhibitors such as topotecan.1 Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma...

  • Cordycepin | AMPK activator
    Cordycepin (73-03-0) is an adenosine analog lacking the hydroxyl at the 3’ position. Inhibits PARP1 and polyadenylation2. Displays anti-inflammatory effects1,3 and neuroprotective effects by inhibiting Aβ-induced...

  • Daunorubicin HCl | DNA Damaging Agent / Anticancer Agent
    Antitumor antibiotic used in the treatment of acute myeloid leukemias.1 Induces DNA damage by intercalation.2 Induces apoptosis in a variety of cell lines.3 Inhibition of autophagy with chloroquine enhances...

  • Focus Biomolecules chemical structure of DMOG | Inhibits prolyl hydroxylase domain-containing proteins | CAS 89464-63-1
    DMOG (89464-63-1) inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α1,2 and inhibiting JMJD2A (IC50 = 2.5 μM)3. Displays neuroprotective effects. Inhibits neuronal cell death caused by...

  • Focus Biomolecules supplier, chemical structure of Doxorubicin HCl | DNA damaging agent | CAS 25316-40-9
    Doxorubicin HCl (25316-40-9) is an antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Doxorubicin HCl induces apoptosis in a variety of cell lines2. Acts as a substrate for MDR13...

  • Focus Biomolecules cell signaling supplier, chemical structure of Epirubicin HCl | DNA damaging agent | CAS 56390-09-1
    Epirubicin HCl (56390-09-1) is an antitumor agent.1 Inhibits topoisomerase II.2 Induces DNA damage by a number of different mechanisms including intercalation, free radical-mediated oxidation, crosslinking,...

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