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Cell Cycle Checkpoints

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  • Focus Biomolecules cell signaling reagent supplier, structure of Apigenin | Protein kinase inhibitor | CAS 520-36-5
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML-277 | CHK2 inhibitor | CAS 516480-79-8
    BML-277 (516480-79-8) is a potent selective inhibitor of Chk2 (IC50 = 15 nM). BML-277 has been screened against a panel of 35 kinases, and shows less that 25% inhibition of any other kinase at 10 μM, demonstrating the...

  • Focus Biomolecules cell signaling reagent supplier, structure of Cantharidin | Phosphatase PP2A inhibitor | CAS 56-25-7
    Cantharidin (56-25-7) inhibits protein phosphatase 2A (Ki=0.19 μM) and PP1 (Ki=1.1 μM)1. Displays >500-fold selectivity over PP2B. Suppresses growth and migration of PANC-1 pancreatic cancer cells via...

  • Focus Biomolecules chemical structure of DMOG | Inhibits prolyl hydroxylase domain-containing proteins | CAS 89464-63-1
    DMOG (89464-63-1) inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α1,2 and inhibiting JMJD2A (IC50 = 2.5 μM)3. Displays neuroprotective effects. Inhibits neuronal cell death caused by...

  • Focus Biomolecules supplier, chemical structure of Indirubin-3'-monoxime | GSK-3 beta and CDK inhibitor | CAS 160807-49-8
    Indirubin-3'-monoxime (160807-49-8) is a potent GSK-3β inhibitor (IC50=22 nM)1. Also inhibits CDK1 (IC50=180 nM) and CDK5 (IC50=100 nM)1. Displays antimitotic properties and induces endoreplication following prophase...

  • Focus Biomolecules cell signaling reagent supplier, structure of Mirin | Mre11-Rad50-Nbs1 inhibitor | CAS 299953-00-7
    Mirin (299953-00-7) is an inhibitor of the Mre11-Rad50-Nbs1(MRN) complex (IC50 = 12 μM for inhibition of ATM activity), part of the MRN-ATM(ataxia-telangiectasia mutated) pathway, an essential pathway for sensing and...

  • Focus Biomolecules cell signaling tech supplier, chemical structure of Nocodazole | Microtubule inhibitor | CAS 31430-18-9
    Nocodazole (31430-18-9) is an antimitotic agent that disrupts microtubules by binding to β tubulin and thereby inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi...

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