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  • Focus Biomolecules cell signaling tech supplier, structure 5-Fluorouracil | Inhibitor of thymidylate synthase | CAS 51-21-8
    $20.00
    5-Fluorouracil (51-21-8) is a clinically useful anticancer agent that acts via irreversible inhibition of thymidylate synthase. The active metabolites of 5-Fluorouracil are 5-Fluorodeoxyuridylate (5-FdUMP),...

  • Focus Biomolecules supplier, chemical structure of 6-Thioguanine | Anticancer agent | Downregulates DNMT1 | CAS 154-42-7
    $30.00
    6-Thioguanine (154-42-7) is a methyltransferase inhibitor.  After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It...

  • A-196 | SUV420H1/H2 methyltransferase inhibitor
    $70.00
    A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Cisplatin | Anticancer agent | CAS 15663-27-1
    $50.00
    Induces intra- and interstrand DNA adducts which poison topoisomerase I.1 Synergizes with topoisomerase I inhibitors such as topotecan.1 Induces apoptosis by sequential activation of caspase-8, -3 and -6 in osteosarcoma...

  • Focus Biomolecules cell signaling reagent supplier, structure of Mirin | Mre11-Rad50-Nbs1 inhibitor | CAS 299953-00-7
    $50.00
    Mirin (299953-00-7) is an inhibitor of the Mre11-Rad50-Nbs1(MRN) complex (IC50 = 12 μM for inhibition of ATM activity), part of the MRN-ATM(ataxia-telangiectasia mutated) pathway, an essential pathway for sensing and...

  • Focus Biomolecules cell signaling tech supplier, structure of Mitomycin C | DNA crosslinking & damaging agent | CAS 50-07-7
    $45.00
    Mitomycin C (50-07-7) is a DNA damaging and crosslinking agent. Induces apoptosis in various cell lines. Cell permeable. This product is not approved for human therapeutic use. References/Citations1) Tee and Proud (2000),...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of RI-1 | RAD51 inhibitor | CAS 415713-60-9
    $52.00
    RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of TH588 | MTH1/NUDT1 inhibitor | CAS 1609960-31-7
    $55.00
    TH588 (1609960-31-7) is a first-in-class nudix hydrolase family inhibitor.1 MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and...

  • Focus Biomolecules reagent supplier, chemical structure of Trifluorothymidine | Thymidylate synthase inhibitor | CAS 70-00-8
    $45.00
    Trifluorothymidine (70-00-8) is an analog of thymidine which inhibits thymidylate synthase possesses antiviral and anticancer activity.1,2  After phosphorylation by thymidine kinase, it is incorporated into DNA where it...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of YM-155 | Survivin inhibitor | CAS 781661-94-7
    $58.00
    YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on...

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