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PARP

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  • Focus Biomolecules cell signaling reagent supplier, structure of 3-Aminobenzamide | PARP inhibitor | CAS 3544-24-9
    $50.00
    3-Aminobenzamide (3544-24-9) inhibits endogenous poly-ADP-ribosyltransferases1. Inhibits nitric oxide-induced apoptosis but not differentiation in HL-60 cells2. Inhibits stress-induced apoptosis3. 3-Aminobenzamide has been...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 4-HQN | PARP inhibitor | CAS 491-36-1
    $30.00
    4-HQN (491-36-1) is an inhibitor of poly(ADP-ribose) polymerase (PARP) (IC50 = 9.5 μM).1 Displays mixed inhibition with respect to NAD+. Protective against ischemia-reperfusion induced ROS production, and subsequent...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Iniparib | PARP inhibitor | CAS 160003-66-7
    $65.00
    Iniparib (160003-66-7) was originally thought to be a PARP1 inhibitor but this is controversial.1,2 Inhibits ionizing radiation-induced single-stranded DNA break repair in lymphoid cell lines in vivo.3 Inhibits growth of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ME-0328 | PARP3 inhibitor | CAS 1445251-22-8
    $75.00
    ME-0328 (1445251-22-8) is a potent and selective PARP3 inhibitor (IC50=0.89 μM). Selective over PARP-1, PARP-2 and other ARDT enzymes (IC50=6.3, 10.8 and >30 μM respectively) References/Citations1) Lindgren et al...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Olaparib | PARP1 inhibitor | CAS 763113-22-0
    $40.00
    Olaparib (763113-22-0) is a highly potent and selective PARP-inhibitor with IC50 values of 5 nM and 1 nM for PARP-1 and PARP-2, respectively.1  In a genetically engineered mouse model for BRCA1-associated breast cancer...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of PJ-34 HCl | PARP1,2 inhibitor | CAS 344458-15-7
    $65.00
    PJ-34 HCl (344458-15-7) is a potent and selective inhibitor of PARP1 and 2. EC50 = 20 nM1. Reduces ischemia reperfusion injury in a mouse model.2 Displays anti-inflammatory effects in a transient focal cerebral ischemia...

  • Rucaparib phosphate | PARP1 inhibitor
    $70.00
    Rucaparib phosphate (459868-92-9) is a potent (Ki<5 nM) PARP1 inhibitor.1 Cytotoxic to human cancer cells or xenograft tumors with mutated or epigenetically silenced BRCA1/2.2 Demonstrates antiproliferative effects in 26...

  • Focus Biomolecules supplier, chemical structure of XAV-939 | Tankyrase inhibitor, Cardiomyogenesis inducer | CAS 284028-89-3
    $45.00
    XAV-939 (284028-89-3) is a tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively).  Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of actin.1  XAV-939...

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