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Epigenetics

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  • (R)-PFI-2 HCl | Methyltransferase SETD7 inhibitor
    $99.00
    (R)-PFI-2 (1627607-87-7) is a potent (IC50 = 2nM) and selective SAM-dependent inhibitor of the lysine methyltransferase SETD7.1 It alters Hippo pathway signaling in MCF7 cells by altering YAP nuclear localization in a...

  • Focus Biomolecules supplier, chemical structure of (±) Tranylcypromine hemisulfate | Demethylase inhibitor | CAS 13492-01-8
    $40.00
    Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4 References/Citations1) Knoll et al. (1980), Monoamine...

  • Focus Biomolecules chemical structure 2'-Deoxy-5-fluorocytidine | DNA methyl transferase inhibitor | CAS 10356-76-0
    $52.00
    2'-Deoxy-5-fluorocytidine (10356-76-0) is a DNA methyltransferase inhibitor currently in clinical trials for breast cancer and other solid tumors1. Like 5'-Azacytidine (Cat.# 10-1267) and decitabine (Cat.# 10-2412),...

  • Focus Biomolecules cell signaling reagent supplier, structure of 5-Azacytidine | DNA hypomethylation agent | CAS 320-67-2
    $20.00
    5-Azacytidine (320-67-2) is specific inhibitor of DNA methyltransferase1. Incorporates into DNA and covalently reacts with and inhibits DNA methyltransferases. Induces demethylation and reactivation of silenced genes2...

  • Focus Biomolecules supplier, chemical structure of 6-Thioguanine | Anticancer agent | Downregulates DNMT1 | CAS 154-42-7
    $30.00
    6-Thioguanine (154-42-7) is a methyltransferase inhibitor.  After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It...

  • A-196 | SUV420H1/H2 methyltransferase inhibitor
    $70.00
    A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AK-7 | SIRT2 inhibitor | CAS 420831-40-9
    $50.00
    AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis genes in primary striatal neurons.1 AK-7 displays...

  • Anacardic Acid | HAT inhibitor
    $35.00
    Anacardic acid (16611-84-0) is a natural product found in cashew nut oil. It is an inhibitor of the histone acetyltransferases p300 and PCAF (IC50’s = 8.5 and 5.0 µM respectively).1 Anacardic acid sensitizes...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apicidin | HDAC inhibitor | CAS 183506-66-3
    $55.00
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

  • Focus Biomolecules cell signaling supplier, chemical structure AS-8351 | KDM5B histone demethylase inhibitor | CAS 796-42-9
    $50.00
    AS-8351 (796-42-9) has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts.1 It is believed that AS-8351 exerts its effects by modulating the activity of the...

  • Focus Biomolecules supplier, chemical structure of B!X-01294 | Histone Methyltransferase inhibitor | CAS 935693-62-2
    $60.00
    BIX-01294 (935693-62-2) is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 μM) as well as GLP HMTase (IC50 = 38 μM) leading to a decrease in H3K9me2(histone H3 lysine 9 methylation) in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML-210 | HDAC inhibitor | CAS 537034-17-6
    $80.00
    BML-210 (537034-17-6) is a novel non-hydroxamic acid HDAC inhibitor. IC50=5-10 μM (HeLa nuclear extract). Induces growth inhibition, proapoptotic and differentiation effects on human leukemia cell lines...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML-278 | SIRT1 activator | CAS 120533-76-8
    $70.00
    BML-278 is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permeable. References/Citations1) Mai et al. (2009), Study of...

  • Bromosporine | Pan-bromodomain inhibitor
    $90.00
    Bromosporine (1619994-69-2) is a potent pan-Bromodomain (BRD) inhibitor.1 Bromosporine was able to reactivate HIV-1 replication in different latency models.2 References/Citations 1) Picaud et al. (2016), Promiscuous...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of C-646 | HAT inhibitor | CAS 328968-36-1
    $80.00
    C-646 (328968-36-1) is a potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. C-646 enhances fear extinction memory and synaptic plasticity in...

  • Focus Biomolecules supplier, chemical structure of Chaetocin | Lys methyltransferase inhibitor | CAS 28097-03-2
    $40.00
    Chaetocin (28097-69-1) is an antimicrobial fungal metabolite. Selective inhibitor of lysine specific histone methtransferase1. Chaetocin has an antimyeloma activity which has been linked to induction of oxidative stress and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CI-994 | HDAC Inhibitor | CAS 112522-64-2
    $30.00
    CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and...

  • CPI-455 | Lysine demethylase KDM5 inhibitor
    $90.00
    CPI-455 (1628208-23-0) is a potent (IC50 = 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C).1 CPI-455 reduced the number of drug-tolerant persister cancer cells (DTPs) in a...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CPTH2 | HAT inhibitor | CAS 357649-93-5
    $69.00
    CPTH2 (357649-93-5) is a selective inhibitor of the histone acetyltransferase Gcn5P both in vitro and in vivo (IC50 = 0.8 mM). In vitro, the HAT inhibitory activity of CPTH2 was caused via bridge-interaction with histone H3...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CTPB | p300 HAT activator | CAS 586976-24-1
    $45.00
    CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2 References/Citations 1) Balasubramanyam et al. (2003), Small molecule modulators of...

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