AS-8351 | KDM5B histone demethylase inhibitor

AS-8351 (796-42-9) has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts.1 It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.1

References/Citations

1) Cao et al. (2016), Conversion of human fibroblasts into functional cardiomyocytes by small molecules; Science, 352 1216

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size :

5 mg, 25 mg

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CAS:
796-42-9

Catalog Number:
10-1597

Activity:
KDM5B histone demethylase inhibitor

Chemical Name:
2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone

Alternate Names:
NSC-51355

Molecular Weight:
Molecular Formula:
C17H13N3O2

Solubility:
Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml), or in Ethanol (up to 10 mg/ml with warming)

Physical Properties:
Yellow solid

Purity:
98% by TLC
NMR (Conforms)

Storage Temperature:
-20°C (des.)

Stability:
Stable for 1 year as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20°C for up to 1 month.

Shipping Code:
RT

AS-8351 | KDM5B histone demethylase inhibitor

$50.00$200.00

CAS:
796-42-9

Catalog Number:
10-1597

Activity:
KDM5B histone demethylase inhibitor

Chemical Name:
2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone

Alternate Names:
NSC-51355

Molecular Weight:
Molecular Formula:
C17H13N3O2

Solubility:
Soluble in DMSO (up to 45 mg/ml), in DMF (up to 30 mg/ml), or in Ethanol (up to 10 mg/ml with warming)

Physical Properties:
Yellow solid

Purity:
98% by TLC
NMR (Conforms)

Storage Temperature:
-20°C (des.)

Stability:
Stable for 1 year as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20°C for up to 1 month.

Shipping Code:
RT

  • 5 mg
  • 25 mg
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