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Daminozide | KDM2/7 demethylase inhibitor

Daminozide (1596-84-5) is a selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 μM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3, KDM4, KDM5 and KDM6) as well as other 2-oxoglutarate oxygenases (FIH, PHD2 and BBOX1), IC50 > 100 μM.1 Decreases tumorsphere formation in human breast cancer cells and acts synergistically with cisplatin in cell killing.2

References/Citations:

1) Rose et al. (2012), Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone methylases; J. Med. Chem., 55 6639
2) Chen et al. (2016), Lysine demethylase 2A promotes stemness and angiogenesis of breast cancer by upregulating Jagged1; Oncotarget, 7 27689

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
size :

50 mg, 250 mg

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CAS:
1596-84-5
Catalog Number:
10-1403
Activity:
KDM2/7 demethylase inhibitor
Alternate Names:
N-(Dimethylamino)succinamic acid
Chemical Name:
1-(2,2-Dimethylhydrazide)butanedioic acid
Molecular Weight:
160.17
Molecular Formula:
C6H12N2O3
Solubility:
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 20 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 3 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

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Daminozide | KDM2/7 demethylase inhibitor

$40.00 – $90.00

CAS:
1596-84-5
Catalog Number:
10-1403
Activity:
KDM2/7 demethylase inhibitor
Alternate Names:
N-(Dimethylamino)succinamic acid
Chemical Name:
1-(2,2-Dimethylhydrazide)butanedioic acid
Molecular Weight:
160.17
Molecular Formula:
C6H12N2O3
Solubility:
Soluble in DMSO (up to 50 mg/ml), or in Water (up to 20 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 3 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
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  • 250 mg
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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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