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GSK2879552 | Potent and selective LSD1 inhibitor

GSK2879552 (1401966-65-5, free base) is potent, selective, and irreversible inhibitor of Lysine Demethylase 1 (LSD1) via covalent modification of the LSD1 cofactor FAD (Ki = 1.7 µM). It is selective for LSD1 over the closely related LSD2, MAO-A, MAO-B, and the FAD dependent enzymes D-amino acid oxidase and glutathione reductase. Tested against a panel of 165 cancer cell lines, GSK2879552 inhibited the proliferation of 9 small cell lung carcinoma lines and 20 AML cell lines.

References/Citations:

1) Mohammad et al. (2015), A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC; Cancer Cell 28 57

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

5 mg, 25 mg

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CAS:
1401966-69-5
Catalog Number:
10-4020
Activity:
Potent and selective LSD1 inhibitor
Chemical Name:
4-[[4-[[[(1R,2S)-2-Phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]benzoic acid dihydrochloride
Molecular Weight:
437.40
Molecular Formula:
C23H28N2O2 • HCl
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Water (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT

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GSK2879552 | Potent and selective LSD1 inhibitor

$80.00 – $265.00

CAS:
1401966-69-5
Catalog Number:
10-4020
Activity:
Potent and selective LSD1 inhibitor
Chemical Name:
4-[[4-[[[(1R,2S)-2-Phenylcyclopropyl]amino]methyl]-1-piperidinyl]methyl]benzoic acid dihydrochloride
Molecular Weight:
437.40
Molecular Formula:
C23H28N2O2 • HCl
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Water (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

SKU: 10-4020 Categories: , , , Tags: , ,
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