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Histone Acetylation

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  • Anacardic Acid | HAT inhibitor
    Anacardic acid (16611-84-0) is a natural product found in cashew nut oil. It is an inhibitor of the histone acetyltransferases p300 and PCAF (IC50’s = 8.5 and 5.0 µM respectively).1 Anacardic acid sensitizes...

  • C-646 | 328968-36-1 | Structure | Supplier
    C-646 (328968-36-1) is a potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. C-646 enhances fear extinction memory and synaptic plasticity in...

  • CPTH2 | HAT inhibitor
    CPTH2 (357649-93-5) is a selective inhibitor of the histone acetyltransferase Gcn5P both in vitro and in vivo (IC50 = 0.8 mM). In vitro, the HAT inhibitory activity of CPTH2 was caused via bridge-interaction with histone H3...

  • CTPB | 586976-24-1 | Structure | supplier
    CTPB (586976-24-1) is a selective activator of p300 HAT (histone acetyltransferase) selective over PCAF (p300 CPB-associated factor).1,2 References/Citations 1) Balasubramanyam et al. (2003), Small molecule modulators of...

  • Emelin | 550-24-3 | Structure | Supplier
    Embelin (550-24-3) inhibits the lysine acetyl transferase PCAF in vitro and in vivo (in vitro IC50=7.2 mM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, H4K12 unchanged1. ...

  • Garcinol | 78824-3-3 | Structure | Supplier
    Garcinol (78824-30-3) is a HAT (histone acetyltransferase) inhibitor (p300 IC50=7 μM and PCAF IC50=5 μM) both in vitro and in vivo.1 It potentiates TRAIL-induced apoptosis of cancer cells. In cancer cells garcinol,...

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