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Histone Deacetylation

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AK-7 | SIRT2 inhibitor | CAS 420831-40-9
    AK-7 | SIRT2 inhibitor
    $50.00
    AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis genes in primary striatal neurons.1 AK-7 displays...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apicidin | HDAC inhibitor | CAS 183506-66-3
    Apicidin | HDAC inhibitor
    $55.00
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

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  • BML-210 | HDAC inhibitor
    BML-210 | HDAC inhibitor
    $80.00
    BML-210 (537034-17-6) is a novel non-hydroxamic acid HDAC inhibitor. IC50=5-10 μM (HeLa nuclear extract). Induces growth inhibition, proapoptotic and differentiation effects on human leukemia cell lines...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BML-278 | SIRT1 activator | CAS 120533-76-8
    BML-278 | SIRT1 activator
    $70.00
    BML-278 is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permeable. References/Citations1) Mai et al. (2009), Study of...

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  • CI-994 | HDAC Inhibitor
    CI-994 | HDAC Inhibitor
    $30.00
    CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and...

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  • CUDC-101 | Dual HDAC and EGFR inhibitor
    CUDC-101 | Dual HDAC and EGFR inhibitor
    $70.00
    A novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2,  IC50 = 4.4, 2.4 and 15.7 nM respectively.1 It not only blocks EGFR and HER2 but...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of EX-527 | SIRT1 inhibitor | CAS 49643-96-3
    EX-527 | SIRT1 inhibitor
    $70.00
    EX-527 (49843-98-3) is a selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable. References/Citations1) Solomon et al...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of HPA | HDAC inhibitor | CAS 96017-59-3
    HPA | HDAC inhibitor
    $40.00
    HPA (96017-59-3) is a histone deacetylase (HDAC) inhibitor, IC50=13 μM1. More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 μM), HSP70 induction and protection against glutamate...

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  • Mocetinostat | Class I HDAC inhibitor
    Mocetinostat | Class I HDAC inhibitor
    $70.00
    Mocetinostat (726169-73-6) is a class I, isoform-selective HDAC inhibitor, IC50s=0.15, 0.29, 1.66 and 0.59 mM for HDAC1, 2, 3 and 11 respectively.1 Induces hyperacetylation of histones, induces expression of the tumor...

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  • Focus Biomolecules supplier, chemical structure of MS-275 (Entinostat) | HDAC inhibitor | CAS 209783-80-2
    MS-275 (Entinostat) | HDAC inhibitor
    $50.00
    MS-275 (Entinostat - 209783-80-2) is a potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 100 μM).1 In vivo, MS-275, has been shown to inhibit tumor growth via induction...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Sodium Valproate | HDAC inhibitor | CAS 1069-66-5
    Na Valproate | HDAC inhibitor
    $26.00
    Sodium Valproate (1069-66-5) is a histone deacetylase inhibitor (IC50 = 400µM).1 Demonstrates neuroprotective, anticancer, and anti-inflammatory activity.2  Inhibits Aβ production, reduced neuritic plaque...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Panobinostat | HDAC inhibitor | CAS 404950-80-7
    Panobinostat | HDAC inhibitor
    $60.00
    Panobinostat (404950-80-7) is a potent inhibitor of class I and II HDACs.1 Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic apoptosis in human CML-BC and AML cells.2 A potent antimyeloma...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Phenylbutyrate Na | HDAC inhibitor | CAS 1716-12-7
    Phenylbutyrate Na | HDAC inhibitor
    $55.00
    Phenylbutyrate Na (1716-12-7) is a histone deacetylase (HDAC) inhibitor. Inhibits proliferation, migration and invasion of a number of cancer cell lines. Phenylbutyrate Na induces differentiation, and apoptosis. Active in...

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  • Piceatannol | SIRT1 activator
    Piceatannol | SIRT1 activator
    $45.00
    Piceatannol (10083-24-6) is a naturally occurring analog of resveratrol (Cat.# 10-1057). Inhibits nonreceptor kinases Syk and Lyk (IC50 approximately 10 μM)1. Piceatannol stimulates Sirt12. References/Citations1) Seow et...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Resveratrol | Antioxidant/SIRT1 activator | CAS 201-36-0
    Resveratrol | Antioxidant/SIRT1 activator
    $45.00
    Resveratrol (501-36-0) is a naturally occurring phenolic antioxidant. Displays antitumor and antiplatelet effects1. Activates SIRT1 and increases longevity in yeast2. Resveratrol ameliorates ageing-related phenotypes by...

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  • RGFP966 | Selective HDAC3 inhibitor
    RGFP966 | Selective HDAC3 inhibitor
    $70.00
    RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50 = 80 nM, no other HDACs inhibited @ 15µM).1 It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events...

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  • Romidepsin | HDAC inhibitor
    Romidepsin | HDAC inhibitor
    $50.00
    Romidepsin (128517-07-7) is a potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively.1 Induces apoptosis in a variety of cell...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SAHA | HDAC inhibitor | CAS 149647-78-9
    SAHA | HDAC inhibitor
    $48.00
    SAHA (149647-78-9) is a potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. SAHA synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable...

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  • SirtAct | Sirt1 activator
    SirtAct | Sirt1 activator
    $80.00
    SirtAct (839699-72-8) is a Sirt1 activator (233% at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells1. SIRT1 stimulation by SirtAct leads to decreased tissue factor...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Sirtinol | SIRT inhibitor | CAS 410536-97-9
    Sirtinol | SIRT inhibitor
    $55.00
    Sirtinol (410536-97-9) is an inhibitor of sirtuin family enzymes including human SIRT1 (IC50=60 μM), human SIRT2 (IC50=58 μM), and yeast Sir2 (IC50=48 μM) with no inhibition of human HDAC1. Active in vivo and in...

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