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Histone Deacetylation

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  • AK-7 | 420831-40-9 | Structure | Supplier
    AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis genes in primary striatal neurons.1 AK-7 displays...

  • Apicidin | HDAC inhibitor
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

  • BML-210 | HDAC inhibitor
    BML-210 (537034-17-6) is a novel non-hydroxamic acid HDAC inhibitor. IC50=5-10 μM (HeLa nuclear extract). Induces growth inhibition, proapoptotic and differentiation effects on human leukemia cell lines...

  • BML-278 | Structure | Supplier
    BML-278 is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permeable. References/Citations1) Mai et al. (2009), Study of...

  • CI-994 | HDAC Inhibitor
    CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and...

  • CUDC-101 | Dual HDAC and EGFR inhibitor
    A novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2,  IC50 = 4.4, 2.4 and 15.7 nM respectively.1 It not only blocks EGFR and HER2 but...

  • EX-527 | 49643-96-3 | Structure | Supplier
    EX-527 (49843-98-3) is a selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable. References/Citations1) Solomon et al...

  • HPA | 96017-59-3 | Structure | Supplier
    HPA (96017-59-3) is a histone deacetylase (HDAC) inhibitor, IC50=13 μM1. More potent and robust than valproic acid at inducing histone hyperacetylation (600% at 50 μM), HSP70 induction and protection against glutamate...

  • Mocetinostat | Class I HDAC inhibitor
    Mocetinostat (726169-73-6) is a class I, isoform-selective HDAC inhibitor, IC50s=0.15, 0.29, 1.66 and 0.59 mM for HDAC1, 2, 3 and 11 respectively.1 Induces hyperacetylation of histones, induces expression of the tumor...

  • MS-275 (Entinostat) | HDAC inhibitor
    MS-275 (Entinostat - 209783-80-2) is a potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 100 μM).1 In vivo, MS-275, has been shown to inhibit tumor growth via induction...

  • Sodium Valproate | 1069-66-5 | Structure | Supplier
    Sodium Valproate (1069-66-5) is a histone deacetylase inhibitor (IC50 = 400µM).1 Demonstrates neuroprotective, anticancer, and anti-inflammatory activity.2  Inhibits Aβ production, reduced neuritic plaque...

  • Panobinostat | HDAC inhibitor
    Panobinostat (404950-80-7) is a potent inhibitor of class I and II HDACs.1 Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic apoptosis in human CML-BC and AML cells.2 A potent antimyeloma...

  • Phenylbutyrate Na | 1716-12-7 | Structure | Supplier
    Phenylbutyrate Na (1716-12-7) is a histone deacetylase (HDAC) inhibitor. Inhibits proliferation, migration and invasion of a number of cancer cell lines. Phenylbutyrate Na induces differentiation, and apoptosis. Active in...

  • Piceatannol | SIRT1 activator
    Piceatannol (10083-24-6) is a naturally occurring analog of resveratrol (Cat.# 10-1057). Inhibits nonreceptor kinases Syk and Lyk (IC50 approximately 10 μM)1. Piceatannol stimulates Sirt12. References/Citations1) Seow et...

  • Resveratrol | 201-36-0 | Structure | Supplier
    Resveratrol (501-36-0) is a naturally occurring phenolic antioxidant. Displays antitumor and antiplatelet effects1. Activates SIRT1 and increases longevity in yeast2. Resveratrol ameliorates ageing-related phenotypes by...

  • Romidepsin | HDAC inhibitor
    Romidepsin (128517-07-7) is a potent and selective inhibitor of class I histone deacetylases (HDACs), IC50 = 36, 47, 510 and 14,000 nM for HDAC1, 2, 4 and HDAC6, respectively.1 Induces apoptosis in a variety of cell...

  • SAHA | 149647-78-9 | Structure | Supplier
    SAHA (149647-78-9) is a potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. SAHA synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable...

  • SirtAct | Sirt1 activator
    SirtAct (839699-72-8) is a Sirt1 activator (233% at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells1. SIRT1 stimulation by SirtAct leads to decreased tissue factor...

  • Sirtinol | 410536-97-9 | Structure | Supplier
    Sirtinol (410536-97-9) is an inhibitor of sirtuin family enzymes including human SIRT1 (IC50=60 μM), human SIRT2 (IC50=58 μM), and yeast Sir2 (IC50=48 μM) with no inhibition of human HDAC1. Active in vivo and in...

  • Splitomicin | Sirt1 inhibitor
    Splitomycin (5690-03-9) was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing...

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