Histone deacetylation
Showing 1–12 of 35 results
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Bioactive Lipids
AK-7 | SIRT2 inhibitor
AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis...$55.00 – $220.00 Select options -
Antifungals
Apicidin | HDAC inhibitor
Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor p...$55.00 – $220.00 Select options -
New Products
BG45 | HDAC3 selective inhibitor
BG45 (926259-99-6) is a potent and selective HDAC3 inhibitor (IC50 = 289 nM), IC50s for HDAC1, 2 and 6 = 2, 2.2 and >20 mM respectively.1 Inhibi...$60.00 – $240.00 Select options -
Epigenetics
BML-210 | HDAC inhibitor
BML-210 (537034-17-6) is a novel non-hydroxamic acid HDAC inhibitor. IC50=5-10 μM (HeLa nuclear extract). Induces growth inhibition, proapoptotic a...$50.00 – $200.00 Select options -
Epigenetics
BML-278 | SIRT1 activator
BML-278 (120533-76-8) is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively...$60.00 – $240.00 Select options -
New Products
BRD73954 | Selective HDAC6/8 inhibitor
BRD73954 (1440209-96-0) is a selective inhibitor of histone deacetylases (HDACs) 6 (IC50 = 36 nM) and 8 (IC50 = 120 nM).1 References/Citations: ...$60.00 – $195.00 Select options -
Apoptosis
CI-994 | HDAC Inhibitor
CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8...$38.00 – $150.00 Select options -
Cancer
CUDC-101 | Dual HDAC and EGFR inhibitor
CUDC-101 (1012054-59-9) is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibit...$70.00 – $280.00 Select options -
Cellular Stress
EX-527 | SIRT1 inhibitor
EX-527 (49843-98-3) is a selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation fol...$40.00 – $125.00 Select options -
New Products
Honokiol | SIRT3 activator
Honokiol (35354-74-6) is a natural product that acts as a SIRT3 activator. It increases mitochondrial oxygen consumption and reduces ROS production...$55.00 – $220.00 Select options -
Cellular Stress
HPA | HDAC inhibitor
HPA (96017-59-3) is a histone deacetylase (HDAC) inhibitor, IC50=13 μM.1 More potent and robust than valproic acid at inducing histone hyperacetyla...$40.00 – $90.00 Select options -
New Products
LMK235 | Selective HDAC4/5 inhibitor
LMK235 (1418033-25-6) is a potent and selective inhibitor of HDAC4 (IC50 = 11.9 nM) and HDAC5 (IC50 = 4.2 nM).1 Cytotoxic against human ovarian can...$60.00 – $225.00 Select options
