Histone deacetylation

Showing 1–12 of 27 results

  • Bioactive Lipids

    AK-7 | SIRT2 inhibitor

    Rated 0 out of 5
    AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis...
    $50.00$185.00 Select options

  • Antifungals

    Apicidin | HDAC inhibitor

    Rated 0 out of 5
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor p...
    $55.00$220.00 Select options

  • Epigenetics

    BML-210 | HDAC inhibitor

    Rated 0 out of 5
    BML-210 (537034-17-6) is a novel non-hydroxamic acid HDAC inhibitor. IC50=5-10 μM (HeLa nuclear extract). Induces growth inhibition, proapoptotic a...
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  • Epigenetics

    BML-278 | SIRT1 activator

    Rated 0 out of 5
    BML-278 is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permea...
    $70.00$280.00 Select options

  • Apoptosis

    CI-994 | HDAC Inhibitor

    Rated 0 out of 5
    CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8...
    $30.00$120.00 Select options

  • Cancer

    CUDC-101 | Dual HDAC and EGFR inhibitor

    Rated 0 out of 5
    CUDC-101 (CAS 1012054-59-9) is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inh...
    $70.00$280.00 Select options

  • Cellular Stress

    EX-527 | SIRT1 inhibitor

    Rated 0 out of 5
    EX-527 (49843-98-3) is a selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation fol...
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  • Cellular Stress

    HPA | HDAC inhibitor

    Rated 0 out of 5
    HPA (96017-59-3) is a histone deacetylase (HDAC) inhibitor, IC50=13 μM1. More potent and robust than valproic acid at inducing histone hyperacetyla...
    $40.00$90.00 Select options

  • Cancer

    Mocetinostat | Class I HDAC inhibitor

    Rated 0 out of 5
    Mocetinostat (726169-73-6) is a class I, isoform-selective HDAC inhibitor, IC50s=0.15, 0.29, 1.66 and 0.59 μM for HDAC1, 2, 3 and 11 respectively.1...
    $70.00$280.00 Select options

  • Arthritis

    MS-275 (Entinostat) | HDAC inhibitor

    Rated 0 out of 5
    MS-275 (Entinostat - 209783-80-2) is a potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 100 μM)....
    $50.00$160.00 Select options

  • Alzheimers

    Na Valproate | HDAC inhibitor

    Rated 0 out of 5
    Sodium Valproate (1069-66-5) is a histone deacetylase inhibitor (IC50 = 400µM).1 Demonstrates neuroprotective, anticancer, and anti-inflammatory ac...
    $26.00 Select options

  • Approved Drugs

    Panobinostat | HDAC inhibitor

    Rated 0 out of 5
    Panobinostat (404950-80-7) is a potent inhibitor of class I and II HDACs.1 Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic ...
    $60.00$240.00 Select options