Histone deacetylation
Showing 1–12 of 27 results
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Bioactive Lipids
AK-7 | SIRT2 inhibitor
AK-7 (420831-40-9) is a selective Sirt2 inhibitor (IC50=15.5 μM) which does not inhibit Sirt1 or Sirt3.1 It down regulates cholesterol biosynthesis...$50.00 – $185.00 Select options -
Antifungals
Apicidin | HDAC inhibitor
Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor p...$55.00 – $220.00 Select options -
Epigenetics
BML-210 | HDAC inhibitor
BML-210 (537034-17-6) is a novel non-hydroxamic acid HDAC inhibitor. IC50=5-10 μM (HeLa nuclear extract). Induces growth inhibition, proapoptotic a...$50.00 – $200.00 Select options -
Epigenetics
BML-278 | SIRT1 activator
BML-278 is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permea...$70.00 – $280.00 Select options -
Apoptosis
CI-994 | HDAC Inhibitor
CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8...$30.00 – $120.00 Select options -
Cancer
CUDC-101 | Dual HDAC and EGFR inhibitor
CUDC-101 (CAS 1012054-59-9) is a novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inh...$70.00 – $280.00 Select options -
Cellular Stress
EX-527 | SIRT1 inhibitor
EX-527 (49843-98-3) is a selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation fol...$70.00 – $280.00 Select options -
Cellular Stress
HPA | HDAC inhibitor
HPA (96017-59-3) is a histone deacetylase (HDAC) inhibitor, IC50=13 μM1. More potent and robust than valproic acid at inducing histone hyperacetyla...$40.00 – $90.00 Select options -
Cancer
Mocetinostat | Class I HDAC inhibitor
Mocetinostat (726169-73-6) is a class I, isoform-selective HDAC inhibitor, IC50s=0.15, 0.29, 1.66 and 0.59 μM for HDAC1, 2, 3 and 11 respectively.1...$70.00 – $280.00 Select options -
Arthritis
MS-275 (Entinostat) | HDAC inhibitor
MS-275 (Entinostat - 209783-80-2) is a potent HDAC inhibitor. Selective for HDAC1 (IC50 = 300 nM) over HDAC3 (IC50 = 8 μM) and HDAC8 (IC50 100 μM)....$50.00 – $160.00 Select options -
Alzheimers
Na Valproate | HDAC inhibitor
Sodium Valproate (1069-66-5) is a histone deacetylase inhibitor (IC50 = 400µM).1 Demonstrates neuroprotective, anticancer, and anti-inflammatory ac...$26.00 Select options -
Approved Drugs
Panobinostat | HDAC inhibitor
Panobinostat (404950-80-7) is a potent inhibitor of class I and II HDACs.1 Cotreatment with panobinostat and an HSP90 inhibitor caused synergistic ...$60.00 – $240.00 Select options
