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Histone Deacetylation

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SirtAct | SIRT1 activator | CAS 839699-72-8
    $80.00
    SirtAct (839699-72-8) is a Sirt1 activator (233% at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells1. SIRT1 stimulation by SirtAct leads to decreased tissue factor...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Sirtinol | SIRT inhibitor | CAS 410536-97-9
    $55.00
    Sirtinol (410536-97-9) is an inhibitor of sirtuin family enzymes including human SIRT1 (IC50=60 μM), human SIRT2 (IC50=58 μM), and yeast Sir2 (IC50=48 μM) with no inhibition of human HDAC1. Active in vivo and in...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Splitomicin | Sirt1 inhibitor | CAS 5690-03-9
    $48.00
    Splitomycin (5690-03-9) was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of TM-2-51 | HDAC8 activator | CAS 4921-82-8
    $50.00
    TM-2-51 (4921-82-8) is a highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 μM. No activation of other HDACs is observed. TM-2-51 rescues the...

  • Focus Biomolecules supplier, chemical structure of Triacetyl resveratrol | SIRT activator, prodrug | CAS 42206-94-0
    $55.00
    Triacetyl resveratrol (CAS 42206-94-0) is a resveratrol prodrug. One method for increasing the half-life of resveratrol in vivo is acetylation of the phenolic OH groups. Deacetylation takes place in vivo or in intact cells...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Trichostatin A | HDAC inhibitor | CAS 58880-19-6
    $85.00
    Trichostatin A (58880-19-6) is a potent and selective histone deacetylase (HDAC) inhibitor (Ki = 3.4 nM). Induces reversion of ras transformed cells to normal morphology. Trichostatin A induces dedifferentiation of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Tubastatin A HCl | HDAC inhibitor | CAS 1310693-92-5
    $55.00
    Tubastatin A (1310693-92-5) is a potent and highly selective inhibitor of HDAC6 (IC50 = 15 nM, >1000-fold selectivity against other HDAC isoforms, approx. 60-fold versus HDAC8).1 It displayed anti-inflammatory and...

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