Histone demethylation
Showing 1–12 of 16 results
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Dedifferentiation
(±) Tranylcypromine hemisulfate | Demethylase inhibitor
Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethyl...$40.00 – $150.00 Select options -
Cardiovascular
AS-8351 | KDM5B histone demethylase inhibitor
AS-8351 (796-42-9) has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts.1 It i...$50.00 – $200.00 Select options -
Cancer
CPI-455 | Lysine demethylase KDM5 inhibitor
CPI-455 (1628208-23-0) is a potent (IC50 = 10 nM) and selective inhibitor of the lysine demethylase KDM5 (equal inhibition of KDM5A, 5B, 5C).1 CPI-...$90.00 – $325.00 Select options -
Epigenetics
Daminozide | KDM2/7 demethylase inhibitor
Daminozide (1596-84-5) is a selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 μM for KDM2A, PHF8 and...$40.00 – $90.00 Select options -
New Products
Deferasirox | Iron Chelator
Deferasirox (201530-41-8) is a clinically useful iron chelator used in long term care of ß-thalassemia and other heavily transfused hematological p...$50.00 – $135.00 Select options -
Cell cycle checkpoints
DMOG | Inhibits prolyl hydroxylase domain-containing proteins
DMOG (89464-63-1) inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α1,2 and inhibiting JMJD2A (IC50 = 2.5 μM)3. Displa...$60.00 – $110.00 Select options -
Epigenetics
GSK-J1 | JMJ H3K27 Demethylase inhibitor (Non-cell permeable)
GSK-J1 (1373422-53-7) is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is ...$75.00 – $300.00 Select options -
Cytokines
GSK-J4 | JMJ H3K27 Demethylase inhibitor (Cell Permeable)
GSK-J4 (1373423-53-0) is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cy...$50.00 – $160.00 Select options -
Cancer
GSK2879552 | Potent and selective LSD1 inhibitor
GSK2879552 (1401966-65-5, free base) is potent, selective, and irreversible inhibitor of Lysine Demethylase 1 (LSD1) via covalent modification of t...$80.00 – $265.00 Select options -
New Products
iJMJD6 | Arginine demethylase JMJD6 inhibitor
iJMJD6 (899548-78-8) is an inhibitor of the arginine demethylase JMJD6 (IC50 = 220 nM) with selectivity over other JmjC domain-containing proteins....$75.00 – $285.00 Select options -
Cellular Metabolism
IOX 1 | JMJD demethylase inhibitor
IOX 1 (5852-78-8) inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, ...$72.00 – $288.00 Select options -
Cancer
JIB-04 | pan-JUMONJI histone demethylase inhibitor
JIB-04 (199596-05-9) is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. I...$60.00 – $210.00 Select options
