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Histone Demethylation

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  • (±) Tranylcypromine hemisulfate | Demethylase inhibitor
    $40.00
    Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4 References/Citations1) Knoll et al. (1980), Monoamine...

  • AS-8351 | 796-42-9 | Structure | Supplier
    $50.00
    AS-8351 (796-42-9) has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts.1 It is believed that AS-8351 exerts its effects by modulating the activity of the...

  • Daminozide | 1596-84-5 | Structure | Supplier
    $40.00
    Daminozide (1596-84-5) is a selective inhibitor of the KDM2/7 JmjC subfamily of histone demethylases. IC50=1.5, 0.55 and 2.1 μM for KDM2A, PHF8 and KDM7A respectively. Highly selective over other subfamily members (KDM3,...

  • DMOG | Inhibits prolyl hydroxylase domain-containing proteins
    $45.00
    DMOG (89464-63-1) inhibits PHD or prolyl hydroxylase domain-containing proteins, activating HIF1α1,2 and inhibiting JMJD2A (IC50 = 2.5 μM)3. Displays neuroprotective effects. Inhibits neuronal cell death caused by...

  • GSK-J1 | 1373422-53-7 | Structure | Supplier
    $75.00
    GSK-J1 (1373422-53-7) is a potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily...

  • GSK-J4 | 1373423-53-0 | Structure | Supplier
    $75.00
    GSK-J4 (1373423-53-0) is a histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the...

  • IOX-1 | 5852-78-8 | Structure | Supplier
    $72.00
    IOX 1 (5852-78-8) inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively.1 A broad...

  • JIB-04 | Structure | Supplier
    $60.00
    JIB-04 (199596-05-9) is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B,...

  • ML-324 | 1222800-79-4 | Structure | Supplier
    $80.00
    ML-324 (1222800-79-4) inhibits JMJD2 histone demethylases. Represses the expression of viral (HCMV and HSV-1) immediate early genes (IC50 ~ 10 μM) and abrogates infection. ML-324 represses the reactivation of HSV from the...

  • PBIT | 2514-30-9 | Structure | Supplier
    $54.00
    PBIT (2514-30-9) is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates...

  • SP-2509 | LSD1 inhibitor
    $70.00
    SP2509 (1423715-09-6) is a potent (IC50 = 13 nM) and reversible inhibitor of the histone demethylase LSD1 (KDM1A).1 It is inactive against the closely related flavin enzymes MAO A,B as well as lactate dehydrogenase, several...

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