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Histone Methylation

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  • (R)-PFI-2 HCl | Methyltransferase SETD7 inhibitor
    (R)-PFI-2 (1627607-87-7) is a potent (IC50 = 2nM) and selective SAM-dependent inhibitor of the lysine methyltransferase SETD7.1 It alters Hippo pathway signaling in MCF7 cells by altering YAP nuclear localization in a...

  • A-196 | SUV420H1/H2 methyltransferase inhibitor
    A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited...

  • Focus Biomolecules supplier, chemical structure of B!X-01294 | Histone Methyltransferase inhibitor | CAS 935693-62-2
    BIX-01294 (935693-62-2) is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 μM) as well as GLP HMTase (IC50 = 38 μM) leading to a decrease in H3K9me2(histone H3 lysine 9 methylation) in...

  • Focus Biomolecules supplier, chemical structure of Chaetocin | Lys methyltransferase inhibitor | CAS 28097-03-2
    Chaetocin (28097-69-1) is an antimicrobial fungal metabolite. Selective inhibitor of lysine specific histone methtransferase1. Chaetocin has an antimyeloma activity which has been linked to induction of oxidative stress and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure DZNep | Methyltransferase inhibitor | CAS 102052-95-9
    DZNep (102052-95-9) is a potent histone methyltransferase inhibitor which decreases global histone methylation.1 Inhibits trimethylation of H3K27 and H4K20 in vitro.1 Selectively induces apoptosis in multiple cancer cell...

  • EPZ015666 | Potent and selective PRMT5 inhibitor
    EPZ015666 (1616391-65-1) is a selective and potent (IC50 = 22nM) inhibitor of arginine methyltransferase 5 (PRMT5).1,2 PRMT5 inhibition with EPZ015666 potently suppressed in vivo glioblastoma tumors3 and significantly...

  • Focus Biomolecules cell signaling supplier, chemical structure of Sinefungin | Methyltransferase inhibitor | CAS 58944-73-3
    Sinefungin (58944-73-3) is a nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferases) inhibitor.1,2 IC50 < 1.0 and 2.5 μM for PRMT1 and SET7/9,...

  • Focus Biomolecules supplier, structure of TC-E 5033 | Arginine methyltransferase 1 (PRMT1) inhibitor | CAS 17328-16-4
    TC-E 5003 (17328-16-4) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor, IC50 = 1.5 μM. Displays no activity against CARM1 and Set7/9 methyltransferases. TC-E 5003 inhibits growth of MCF7a breast...

  • Focus Biomolecules cell signaling supplier, chemical structure UNC0379 | Selective SETD8 inhibitor | CAS 1620401-82-2
    UNC0379 (CAS 1620401-82-2) is an inhibitor of the lysine methyltransferase SETD8 with selectivity over 15 other methyltransferases.1 IC50’s = 7.3 µM in a radioactive methyl transfer assay and 9.0 µM in an...

  • Focus Biomolecules cell signaling supplier, chemical structure of UNC1999 | Methyltransferase inhibitor | CAS 1431612-23-5
    UNC1999 (1431612-23-5) is an orally bioavailable, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50's = 45 nM and 2 nM respectively).1 Inhibition of EZH2 with UNC1999...

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