Sinefungin | Methyltransferase inhibitor
NMR (Conforms)
Sinefungin (58944-73-3) is a nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferases) inhibitor.1,2 IC50 < 1.0 and 2.5 μM for PRMT1 and SET7/9, respectively.3 Sinefungin binds with greater affinity to the adenine-specific DNA methyltransferase M.TaqI than S-adenosyl-L-homocysteine.4 Inhibits biofilm formation by Streptococcus pneumoniae.5
References/Citations:
1) Barbes et al. (1990), Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria; FEMS Microbiol. Lett., 57 239
2) Yebra et al. (1991), The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces; J. Antibiot. (Tokyo), 44 1141
3) Cheng et al. (2004), Small molecule regulators of protein arginine methyltransferases; J. Biol. Chem., 279 23892
4) Schluckebier et al. (1997), Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to adenine-specific DNA methyltransferase M. TaqI; J. Mol. Biol., 265 56
5) Yadav et al. (2014), Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumonia biofilm growth; Biomed. Res. Int., 2014 156987
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Sinefungin (58944-73-3) is a nucleoside S-adenosyl-1-methionine analog. Potent, competitive methyltransferase (protein, DNA, and RNA methyltransferases) inhibitor.1,2 IC50 < 1.0 and 2.5 μM for PRMT1 and SET7/9, respectively.3 Sinefungin binds with greater affinity to the adenine-specific DNA methyltransferase M.TaqI than S-adenosyl-L-homocysteine.4 Inhibits biofilm formation by Streptococcus pneumoniae.5
References/Citations:
1) Barbes et al. (1990), Effects of sinefungin and S-adenosylhomocysteine on DNA and protein methyltransferases from Streptomyces and other bacteria; FEMS Microbiol. Lett., 57 239
2) Yebra et al. (1991), The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces; J. Antibiot. (Tokyo), 44 1141
3) Cheng et al. (2004), Small molecule regulators of protein arginine methyltransferases; J. Biol. Chem., 279 23892
4) Schluckebier et al. (1997), Differential binding of S-adenosylmethionine S-adenosylhomocysteine and Sinefungin to adenine-specific DNA methyltransferase M. TaqI; J. Mol. Biol., 265 56
5) Yadav et al. (2014), Sinefungin, a natural nucleoside analogue of S-adenosylmethionine, inhibits Streptococcus pneumonia biofilm growth; Biomed. Res. Int., 2014 156987
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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