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Extracellular Matrix and Adhesion

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  • Actinonin | Leucyl aminopeptidase inhibitor
    Actinonin | Leucyl aminopeptidase inhibitor
    $35.00
    Actinonin (13434-13-4) is a potent hydroxamic acid inhibitor of aminopeptidases which displays analgesic effects by inhibiting enkephalin-degrading enzymes.1 Actinonin also inhibits peptide deformylase.2 Induces...

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  • Ansatrienin B | Cytotoxic activity
    Ansatrienin B | Cytotoxic activity
    $345.00
    Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1...

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  • BAY 11-7082 | 19542-67-7 | Structure | Supplier
    BAY 11-7082 | IKK inhibitor
    $70.00
    BAY 11-7082 (19542-67-7) selectively inhibits TNFα-induced phosphorylation of IκB-α leading to decreased nuclear NF-κB and decreased adhesion molecule expression without affecting constitutive...

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  • CL-82198 | 307002-71-7 | Structure | Supplier
    CL-82198 | MMP-13 inhibitor
    $50.00
    CL-82198 (307002-71-7) is a selective inhibitor of MMP-13 (IC50 = 10 μM). It displayed no activity against MMP-1, MMP-9 or TACE. References/Citations1) Chen, et al. (2000), Structure-based design of a novel, potent, and...

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  • FAK inhibitor 14 | FAK inhibitor
    FAK inhibitor 14 | FAK inhibitor
    $45.00
    FAK inhibitor 14 (4506-66-5) is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397...

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  • Fasudil HCl | ROCK inhibitor
    Fasudil HCl | ROCK inhibitor
    $80.00
    Fasudil HCl (105628-07-7) is a Rho-associated kinase inhibitor (IC50 = 1.9 μM and 10.7 μM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic...

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  • Ilomastat | GM-6001 | GM6001 | 142880-36-2 | structure | Supplier
    Ilomastat (GM-6001) | MMP inhibitor
    $55.00
    Ilomastat (142880-36-2) is a potent pan-specific inhibitor of matrix metalloproteinases (MMPs).1 Ki values have been reported for the following human MMPs: MMP-1, 0.4nM; MMP-2, 0.5nM; MMP-3, 27nM; MMP-7, 3.7nM; MMP-8, 0.1nM;...

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  • NNGH | 161314-17-6 | Structure | supplier
    NNGH | MMP inhibitor (pan specific)
    $55.00
    NNGH (161314-17-6) is a potent pan-specific inhibitor of matrix metalloproteinases ( MMP3 Ki=0.013 μM). Inhibits MMP-1, -2, -7-10, -12-14 and MMP-20. Attenuates inflammation-induced thermal hyperalgesia. Cell Permeable...

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  • Sphingosine-1-phosphate | EDG receptor ligand
    Sphingosine-1-phosphate | EDG receptor ligand
    $65.00
    Sphingosine-1-phosphate (26993-30-6) is an endogenous sphingolipid metabolite known to be involved in many cellular responses including angiogenesis, vascular maturation, cardiac development and immunity. These effects are...

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  • WHI-P131 | 202475-60-3 | Structure | Supplier
    WHI-P131 | JAK3 inhibitor
    $50.00
    WHI-P131 (202475-60-3) is a JAK3 inhibitor. Inhibits human glioblastoma cell adhesion and invasion1. Increases survival in a mouse ALS model2. References/Citations1) Narla et al. (1998), Inhibition of human glioblastoma...

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  • Y-27632 dihydrochloride | ROCK family kinase inhibitor
    Y-27632 dihydrochloride | ROCK family kinase inhibitor
    $40.00
    Y-27632 dihydrochloride (129830-38-2) is a specific inhibitor of ROCK family kinases.1 Enhances stem cell survival and proliferation in culture.2 Y-27632 dihydrochloride significantly improves freeze/thaw survival rate for...

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