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Product Details

FAK inhibitor 14 | FAK inhibitor

FAK inhibitor 14 (4506-66-5) is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397 (IC50 = 1 μM), promotes cell detachment and inhibits cell adhesion in vitro. FAK inhibitor 14 exhibits antiproliferative activity in a variety of human tumor cell lines in vitro and in breast cancer cells in vivo. Induces regression of pancreatic tumors2 and glioblastoma3. Displays antiangiogenic activity4.

1) Golubovskaya et al. (2008), A small mo;ecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth; J. Med. Chem., 51 7405
2) Hochwald et al. (2009), A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer; Cell Cycle, 8 2435
3) Golubovskaya et al. (2013), Pharmacologic blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide; Mol. Cancer Ther., 12 162
4) Cabrita et al. (2011), Focal Adhesion kinase inhibitors are potent anti-angiogenic agents; Mol. Oncol., 5 517

Focus Biomolecules cell signaling reagent supplier, chemical structure of FAK inhibitor 14 | FAK inhibitor | CAS 4506-66-5

Catalog#  10-2547

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Catalog Number:
FAK inhibitor
Alternate Names:
Chemical Name:
1,2,4,5-Benzenetetramine tetrahydrochloride
Molecular Weight:
Molecular Formula:
C6H10N4 4HCl
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 15 mg/ml).
Physical Properties:
Grey solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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