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Gene Regulation

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  • 3-Aminobenzamide | 3544-24-9 | Structure | Supplier
    3-Aminobenzamide | PARP inhibitor
    $50.00
    3-Aminobenzamide (3544-24-9) inhibits endogenous poly-ADP-ribosyltransferases1. Inhibits nitric oxide-induced apoptosis but not differentiation in HL-60 cells2. Inhibits stress-induced apoptosis3. 3-Aminobenzamide has been...

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  • 5-Ethynyl-2'-deoxyuridine | DNA labeling
    5-Ethynyl-2'-deoxyuridine | DNA labeling
    $50.00
    5-Ethynyl-2'-deoxyuridine (61135-33-9) is a novel agent for fast and sensitive detection of DNA synthesis in vivo1. 5-EdU is incorporated into proliferating cells followed by detection with a fluorescent azide using click...

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  • 5-Fluorouridine | Proapoptotic antiproliferative agent
    5-Fluorouridine | Proapoptotic antiproliferative agent
    $70.00
    5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1  Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms...

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  • 7-Aminoactinomycin D | Fluorescent DNA Probe
    7-Aminoactinomycin D | Fluorescent DNA Probe
    $74.00
    7-Aminoactinomycin D (7240-37-1) is a fluorescent, intercalating DNA-binding agent useful for identifying apoptotic cells by flow cytometry. 1,2 Capable of identifying populations representing live, apoptotic, and late...

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  • Actinomycin D | Transcription inhibitor
    Actinomycin D | Transcription inhibitor
    $50.00
    Actinomycin D (50-76-0) is a cyclopeptide antibiotic and intercalating transcription inhibitor with anti-neoplastic activity. Potent inhibitor of RNA polymerase.1 Induces apoptosis in a variety of cancer cell...

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  • Anisomycin | Anoikis sensitizer
    Anisomycin | Anoikis sensitizer
    $35.00
    Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable. References/Citations1) Hazzalin et al...

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  • Ansatrienin B | Cytotoxic activity
    Ansatrienin B | Cytotoxic activity
    $345.00
    Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1...

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  • Aphidicolin | DNA polymerase inhibitor
    Aphidicolin | DNA polymerase inhibitor
    $70.00
    Aphidicolin (38966-21-1) specifically inhibits DNA polymerase α and δ via binding to the enzyme, in eukaryotic cells such as the HeLa cell line, without affecting other DNA polymerases1. Arrests cell cycle at...

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  • Apicidin | HDAC inhibitor
    Apicidin | HDAC inhibitor
    $55.00
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

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  • BI-6015 | 93987-29-2 | Structure | Supplier
    BI-6015 | HNF4a inhibitor
    $48.00
    BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to...

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  • Blasticidin S HCl | Antibiotic selection agent
    Blasticidin S HCl | Antibiotic selection agent
    $80.00
    Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1 Inhibits translation by trapping deformed tRNA on the ribosome.1 The ABC-type transporter NppA1A2BCD...

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  • Borrelidin | 7184-60-3 | Structure | Supplier
    Borrelidin | Angiogenesis inhibitor
    $190.00
    Novel macrolide which inhibits bacterial and eukaryotic threonyl-tRNA synthetase.1 Displays potent anti-angiogenic activity (IC50=0.8 nM) and induces the collapse of newly formed capillary tubules.2 Modulates alternative...

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  • Camptothecin | 7689-03-4 | Structure | Supplier
    Camptothecin | Topoisomerase I inhibitor
    $55.00
    Camptothecin (7689-03-4) is a natural product isolated from the Chinese Happy Tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I. Camptothecin binds irreversibly to the topoisomerase I /DNA complex...

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  • Cycloheximide | 66-81-9 | Structure | Supplier
    Cycloheximide | Protein synthesis inhibitor
    $35.00
    Cycloheximide (66-81-9) is a protein synthesis inhibitor. Induces apoptosis. Antifungal activity. Cell permeable. References/Citations1) Merck 14:2728

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  • Doxorubicin HCl | DNA damaging agent
    Doxorubicin HCl | DNA damaging agent
    $70.00
    Doxorubicin HCl (25316-40-9) is an antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Doxorubicin HCl induces apoptosis in a variety of cell lines2. Acts as a substrate for MDR13...

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  • Echinomycin | HIF-1alpha inhibitor
    Echinomycin | HIF-1alpha inhibitor
    $90.00
    Echinomycin is a potent and selective hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the interaction of HIF-1α.1 Protects mice against relapsed...

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  • Etoposide | 33419-42-0 | Structure | Supplier
    Etoposide | Topoisomerase II inhibitor
    $68.00
    Etoposide (33419-42-0) is a chemotherapeutic agent that forms a ternary complex with DNA and topoisomerase II, preventing re-ligation of DNA strands causing DNA cleavage. Etoposide blocks the cell cycle in S-phase and...

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  • Gemcitabine HCl | DNA polymerase inhibitor
    Gemcitabine HCl | DNA polymerase inhibitor
    $30.00
    Gemcitabine HCl (122111-03-9) is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of...

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  • Helenalin | NFkB inhibitor
    Helenalin | NFkB inhibitor
    $238.00
    Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1 and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms3...

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  • Herboxidiene | 142861-00-5 | Structure | Supplier
    Herboxidiene | Spliceosome inhibitor
    $80.00
    Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit...

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