Gene Regulation

5-Ethynyl-2'-deoxyuridine (61135-33-9) is a novel agent for fast and sensitive detection of DNA synthesis in vivo1. 5-EdU is incorporated into proliferating cells followed by detection with a fluorescent azide using click...

Actinomycin D (50-76-0) is a clinically useful antitumor agent. Actinomycin D has the ability to inhibit transcription by binding DNA at the transcription initiation complex and preventing elongation of RNA chain by RNA...

Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1...

Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1 Inhibits translation by trapping deformed tRNA on the ribosome.1 The ABC-type transporter NppA1A2BCD...

Camptothecin (7689-03-4) is a natural product isolated from the Chinese Happy Tree, Camptotheca acuminate. It is an inhibitor of DNA topoisomerase I. Camptothecin binds irreversibly to the topoisomerase I /DNA complex...

Doxorubicin HCl (25316-40-9) is an antitumor antibiotic. Induces DNA damage by intercalation1 and inhibition of topoisomerase II. Doxorubicin HCl induces apoptosis in a variety of cell lines2. Acts as a substrate for MDR13...

Etoposide (33419-42-0) is a chemotherapeutic agent that forms a ternary complex with DNA and topoisomerase II, preventing re-ligation of DNA strands causing DNA cleavage. Etoposide blocks the cell cycle in S-phase and...

Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1 and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms3...

Hypericin (548-04-9) is a natural product found in St. John's Wort (Hypericum perforatum). A multifunctional agent that has been reported to be antidepressive, antineoplastic, antitumor and antiviral. Inhibitory effects have...