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BiochemicalTargets

Gene regulation

Gene regulation is a broad topic that includes epigenetics, transcription, translation, post-translational modification, protein degradation, and all possible steps in between that affect DNA, RNA, and proteins. Focus Biomolecules offers modulators for each of these categories.

CRISPR

RS-1 | RAD51 activator / CRISPR enhancer

CAS:
312756-74-4
Catalog Number:
10-4099
Activity:
RAD51 activators / CRISPR enhancer
Chemical Name:
4-Bromo-N-(4-bromophenyl)-3-[[(phenylmethyl)amino]sulfonyl]benzamide
Molecular Weight:
524.23
Molecular Formula:
C20H16BrN2O3S
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Zidovudine | Antiretroviral / Enhances CRISPR repair

CAS:
30516-87-1
Catalog Number:
10-4615
Activity:
Antiretroviral / Enhances CRISPR repair
Chemical Names:
Azidothymidine; AZT
Molecular Weight:
267.24
Molecular Formula:
C10H13N5O4
Solubility:
Soluble in DMSO (>40 mg/ml); ethanol (>25 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

DNA polymerase

Fludarabine | DNA biosynthesis inhibitor

CAS:
21679-14-1
Catalog Number:
10-5047
Activity:
DNA synthesis inhibitor
Chemical Names:
9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine; F-ara-A; NSC118218
Molecular Weight:
285.23
Molecular Formula:
C10H12FN5O4
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

7-Aminoactinomycin D | Fluorescent DNA Probe

CAS:
7240-37-1
Catalog Number:
10-2053
Activity:
Fluorescent DNA probe
Molecular Weight:
1270.42
Molecular Formula:
C62H87N13O16
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Purple solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions should be made fresh daily.
Shipping Code:
RT

Gemcitabine HCl | DNA polymerase inhibitor

CAS:
122111-03-9
Catalog Number:
10-2140
Activity:
DNA polymerase inhibitor
Alternate Names:
dFdC
Chemical Name:
2′-Deoxy-2′,2′-difluorocytidine hydrochloride
Molecular Weight:
299.66
Molecular Formula:
C9H11F2N3O4 HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98%
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

DNA topoisomerase

ß-Lapachone | Topoisomerase-1 inhibitor

CAS:
4707-32-8
Catalog Number:
10-2386
Activity:
Topoisomerase I inhibitor
Chemical Name:
3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Alternate Name:
NSC-26326
Molecular Formula:
C15H14O3
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

SN-38 | DNA topoisomerase I inhibitor

CAS:
86639-52-3
Catalog Number:
10-2425
Activity:
DNA topoisomerase I inhibitor
Chemical Name:
7-Ethyl-10-hydroxycamptothecin
Molecular Weight:
392.41
Molecular Formula:
C22H20N2O5
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Gemcitabine HCl | DNA polymerase inhibitor

CAS:
122111-03-9
Catalog Number:
10-2140
Activity:
DNA polymerase inhibitor
Alternate Names:
dFdC
Chemical Name:
2′-Deoxy-2′,2′-difluorocytidine hydrochloride
Molecular Weight:
299.66
Molecular Formula:
C9H11F2N3O4 HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Water (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98%
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
RT

eIF2a

ISRIB | Integrated stress response inhibitor

CAS:
159403-47-8
Catalog Number:
10-1539
Activity:
Integrated stress response inhibitor
Chemical Name:
N.N’-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide
Alternate Names:
trans-ISRIB
Molecular Weight:
451.34
Molecular Formula:
C22H24Cl2N2O4
Solubility:
Soluble in DMSO (up to 5 mg/ml with warming)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Salubrinal | eIF2α Phosphatase inhibitor

CAS:
405060-95-9
Catalog Number:
10-4517
Activity:
eIF2α Phosphatase inhibitor
Chemical Name:
3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Molecular Weight:
479.81
Molecular Formula:
C21H17Cl3N4OS
Solubility:
Soluble in DMSO (up to 25 mg/ml),
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Nuclear receptors

C-DIM 12 | Nurr1 activator; NFkB inhibitor

CAS:
178946-89-9
Catalog Number:
10-3280
Activity:
Nurr1 activator; NFkB inhibitor
Chemical Name:
3,3’-[(4-Chlorophenyl)methylene]bis[1H-indole]
Molecular Weight:
356.85
Molecular Formula:
C23H17ClN2
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

PARP

Rucaparib phosphate | PARP1 inhibitor

CAS:
459868-92-9
Catalog Number:
10-3321
Activity:
PARP1 inhibitor
Chemical Name:
8-Fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-6H-pyrrolo[4,3,2-ef][2]benzazepin-6-on
Alternate Name:
AG-14699; PF01367338
Molecular Weight:
421.36
Molecular Formula:
C19H18FN3O • H3PO4
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Olaparib | PARP1 inhibitor

CAS:
763113-22-0
Catalog Number:
10-2154
Activity:
PARP1 inhibitor
Chemical Name:
4-(3-(4-(Cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazine-1(2H)-one
Alternate Names:
AZD-2281; KU-59436
Molecular Weight:
434.47
Molecular Formula:
C24,/sub>H23,/sub>FN<sub.4< sub=””>O3</sub.4<>
Solubility:
Soluble in DMSO (up to 33 mg/ml) or in Ethanol (up to 1.7 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT

PJ-34 HCl | PARP1/2 inhibitor

CAS:
344458-15-7
Catalog Number:
10-2395
Activity:
PARP1,2 inhibitor
Chemical Name:
N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride
Molecular Weight:
331.81
Molecular Formula:
C17H17N3O2
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Water (up to 20 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT

Protein synthesis

Halofuginone HBr | Prolyl-tRNA synthetase inhibitor

Halofuginone (64924-67-0) is a potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and

Homoharringtonine | Protein synthesis inhibitor

CAS:
26833-87-4
Catalog Number:
10-3033
Activity:
Protein synthesis inhibitor
Chemical Names:
Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate
Alternate Name:
HHT; NSC141633; Omacetaxine mepesuccinate
Molecular Weight:
545.63
Molecular Formula:
C29H39NO9
Solubility:
Soluble in DMSO (75 mg/ml)
Physical Properties:
Pale yellow to off-white solid
Purity:
>95% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Lycorine HCl | Protein synthesis inhibitor/SCAP degrader

CAS:
2188-68-3
Catalog Number:
10-2608
Activity:
Protein synthesis inhibitor/SCAP degrader
Chemical Names:
Galanthidine; Amarylline; Narcissine
Molecular Weight:
323.77
Molecular Formula:
C16H17NO4·HCl
Solubility:
Soluble in water (15 mg/ml)
Physical Properties:
White to off-white solid
Purity:
98% TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in water may be stored at -20°C for up to 1 month.
Shipping Code:
RT

RNA Polymerase

AOH1996 | PCNA inhibitor

AOH1996 (2089314-64-5) inhibits proliferating cell nuclear antigen (PCNA), an enzyme critical to DNA replication and repair processes.1  It enhances the interaction between PCNA and RPB1 subunit

BMH-21 | RNA Polymerase I inhibitor

BMH-21 (896705-16-1) is a planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 µM in U2OS cells, but not Pols II or

Vacuolin-1 | Autophagy/PIKfyve inhibitor

Vacuolin-1 (351986-85-1) inhibits autophagy via inhibition of Ca2+-dependent fusion of lysosomes with the plasma membrane and the release of lysosomal content and has no effect on

Telomerase

BIBR1532 | Telomerase inhibitor

BIBR1532 (321674-73-1) is a non-competitive specific inhibitor of telomerase (IC50 = 93 nM), targeting telomerase reverse transcriptase (hTERT).1,2 Induces apoptosis in MCF-7 breast cancer cells and breast cancer

Helenalin | NFkB inhibitor

CAS:
6754-13-8
Catalog Number:
10-2783
Activity:
NFκB inhibitor
Chemical Name:
Natural sesquiterpenoid from Arnica species
Molecular Weight:
262.31
Molecular Formula:
C15H18O4
Solubility:
Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Transcription

HC-258 | Covalent TEAD inhibitor

HC-258 is a covalent inhibitor of TEAD (transcriptional enhanced associate domain), an important component of the Hippo pathway.  It was able to reduce gene expression levels

Indisulam | RBM39 Molecular glue

Indisulam (165668-41-7) was originally described as a potent antitumor agent that targeted the G1 phase of cell cycle via suppression of activation of CDK2 and cyclin

BRM014 | BRM/BRG1 ATPase inhibitor

SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily A member 2 (SMARCA2), also known as Brahma homologue (BRM), together with its close homologue Brahma-related gene 1 (BRG1),

Other

HC-258 | Covalent TEAD inhibitor

HC-258 is a covalent inhibitor of TEAD (transcriptional enhanced associate domain), an important component of the Hippo pathway.  It was able to reduce gene expression levels

Streptonigrin | Induces heterochromatin formation

CAS:
3930-19-6
Catalog Number:
10-3484
Activity:
Induces heterochromatin formation
Source:
Fermenation product from Streptomyces flocculus
Alternate Names:
Bruneomycin; NSC-45383
Molecular Weight:
506.47
Molecular Formula:
C25H22N4O8
Solubility:
Soluble in DMSO
Physical Properties:
Black solid
Purity:
>95% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Fludarabine | DNA biosynthesis inhibitor

CAS:
21679-14-1
Catalog Number:
10-5047
Activity:
DNA synthesis inhibitor
Chemical Names:
9-β-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine; F-ara-A; NSC118218
Molecular Weight:
285.23
Molecular Formula:
C10H12FN5O4
Solubility:
Soluble in DMSO (30 mg/ml)
Physical Properties:
White solid
Purity:
98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT