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  • Focus Biomolecules reagent supplier, chemical structure of 5-Ethynyl-2'-deoxyuridine | DNA labeling | CAS 61135-33-9
    $50.00
    5-Ethynyl-2'-deoxyuridine (61135-33-9) is a novel agent for fast and sensitive detection of DNA synthesis in vivo1. 5-EdU is incorporated into proliferating cells followed by detection with a fluorescent azide using click...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Anisomycin | Anoikis sensitizer | CAS 22862-76-6
    $35.00
    Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable. References/Citations1) Hazzalin et al...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apicidin | HDAC inhibitor | CAS 183506-66-3
    $55.00
    Apicidin (183506-66-3) is a fungal toxin that is a potent, cell permeable inhibitor of histone deacetylases (HDAC's).1 It also displays antitumor properties by inducing changes in p21WAF1/Cip1 and gelsolin gene expression...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BI-6015 | HNF4a inhibitor | CAS 93987-29-2
    $48.00
    BI-6015 (93987-29-2) is a hepatocyte nuclear factor 4α (HNF4α) antagonist. HNF4α is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis.1 BI-6015 binds to...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Echinomycin | HIF-1alpha inhibitor | CAS 512-64-1
    $90.00
    Echinomycin (CAS 512-64-1) is a potent and selective hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the interaction of HIF-1α.1 Protects mice...

  • Focus Biomolecules cell signaling supplier, chemical structure of Herboxidiene | Spliceosome inhibitor | CAS 142861-00-5
    $80.00
    Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit...

  • Focus Biomolecules supplier, chemical structure IPTG (animal free) | Induces beta-galactosidase in bacteria | CAS 367-93-1
    $25.00
    IPTG (367-93-1; animal free) induces β-galactosidase in bacteria.

  • Focus Biomolecules cell signaling supplier, chemical structure of ML-60218 | RNA Polymerase III inhibitor | CAS 577784-91-9
    $90.00
    ML-60218 (CAS 577784-91-9) is a broad spectrum inhibitor of RNA polymerase III from S. Cerevisiae as well as from human cells, IC50=32 mM and 27 mM respectively.1   Combined treatment with ML-60218 and an HDAC...

  • Focus Biomolecules supplier, chemical structure N-Acetyl Puromycin | Down regulates SnoN & Ski expression | CAS 22852-13-7
    $65.00
    N-Acetyl Puromycin (22852-13-7) down regulates SnoN and Ski protein expression. Induces TGF-β signaling, independently of MAPK activation. Does not bind ribosomes or block protein synthesis. References/Citations 1)...

  • Focus Biomolecules supplier, chemical structure of NSC 95397 | CtBP inhibitor; Cdc25 phosphatase inhibitor | CAS 93718-83-3
    $80.00
    NSC 95397 (93718-83-3) is a potent and selective inhibitor of Cdc25 phosphatase (Ki  = 32, 96 and 40 nM for Cdc25A, B and C respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M...

  • Focus Biomolecules cell signaling supplier, chemical structure of PRT4165 | E3 ubiquitin ligase inhibitor | CAS 31083-55-3
    $65.00
    PRT-4165 (31083-55-3) is an inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks...

  • Focus Biomolecules cell signaling reagent supplier, structure of Retinoic acid | Retinoid RAR agonist | CAS 302-79-4
    $22.00
    all-trans-Retinoic acid (302-79-4) a metabolite of Vitamin A, is an endogenous ligand for the retinoic acid receptor (RAR). The binding of retinoic acid to the RAR and retinoid X (RXR) heterodimer causes conformation changes...

  • Focus Biomolecules cell signaling reagent supplier, structure of Roscovitine | p34/cdc2 inhibitor | CAS 186692-46-6
    $35.00
    Roscovitine (186692-46-6) is a potent and selective inhibitor of cyclin-dependent kinases displaying higher potency and selectivity compared to olomoucine.  p34 cdc2 IC50 = 0.2 µM.  Also inhibits p33cdk2 and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SC-514 | IKK-2 inhibitor | CAS 354812-17-2
    $65.00
    SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Splitomicin | Sirt1 inhibitor | CAS 5690-03-9
    $48.00
    Splitomycin (5690-03-9) was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing...

  • Focus Biomolecules supplier, chemical structure of SR-9009 | RevErb alpha & beta agonist | CAS 1379686-30-2
    $70.00
    SR-9009 (1379686-30-2) is an agonist at nuclear receptor Rev-ErbA1. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model2. SR-9009 suppresses...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SR9243 | LXR inverse agonist | CAS 1613028-81-1
    $45.00
    SR9243 (1613028-81-1) is an LXR inverse agonist that significantly inhibits the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression.1 Induces apoptosis in a variety of cancer cell types...

  • Focus Biomolecules cell signaling reagent supplier, structure of TG003 | Clk family kinase inhibitor | CAS 719277-26-6
    $78.00
    TG003 (719277-26-6) is a potent, ATP-competitive inhibitor of Clk-family kinases (IC50's = 15, 20 and 200 nM for mClk4, 1 and 2 respectively and >10 μM for mClk3)1. Also inhibits DYRK1A/B (IC50's = 24 and 34 nM...

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