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Protein synthesis

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  • 5-Ethynyl-2'-deoxyuridine | DNA labeling
    5-Ethynyl-2'-deoxyuridine (61135-33-9) is a novel agent for fast and sensitive detection of DNA synthesis in vivo1. 5-EdU is incorporated into proliferating cells followed by detection with a fluorescent azide using click...

  • 5-Fluorouridine | Proapoptotic antiproliferative agent
    5-Fluorouridine (316-46-1) is an inhibitor of ribozyme self-cleavage in mammalian cells.1  Induces apoptosis in HCT-116 colorectal carcinoma cells causing diverse gene expression patterns suggesting that mechanisms...

  • Focus Biomolecules supplier, chemical structure of Actinomycin D | Transcription inhibitor | CAS 50-76-0
    Actinomycin D (50-76-0) is a cyclopeptide antibiotic and intercalating transcription inhibitor with anti-neoplastic activity. Potent inhibitor of RNA polymerase.1 Induces apoptosis in a variety of cancer cell...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Anisomycin | Anoikis sensitizer | CAS 22862-76-6
    Anisomycin (22862-76-6) activates JNK/SAPKs and reduces c-fos and c-jun. Protein synthesis inhibitor. Anisomycin induces apoptosis and sensitizes cells to anoikis. Cell permeable. References/Citations1) Hazzalin et al...

  • Ansatrienin B | Cytotoxic activity
    Ansatrienin b (82189-04-6) represents a novel class of ansamycins.1 Inhibits osteoclastic bone resorption.2 Potentiates the activity of several clinically useful antitumor agents.3 Translation inhibitor which prevents ICAM-1...

  • Blasticidin S HCl | Antibiotic selection agent
    Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1 Inhibits translation by trapping deformed tRNA on the ribosome.1 The ABC-type transporter NppA1A2BCD...

  • Focus Biomolecules supplier, chemical structure of Borrelidin | Angiogenesis inhibitor | CAS 7184-60-3
    Novel macrolide which inhibits bacterial and eukaryotic threonyl-tRNA synthetase.1 Displays potent anti-angiogenic activity (IC50=0.8 nM) and induces the collapse of newly formed capillary tubules.2 Modulates alternative...

  • Focus Biomolecules cell signaling reagent supplier, structure Cycloheximide | Protein synthesis inhibitor | CAS 66-81-9
    Cycloheximide (66-81-9) is a protein synthesis inhibitor. Induces apoptosis. Antifungal activity. Cell permeable. References/Citations1) Merck 14:2728

  • IPTG (animal free) | Induces beta-galactosidase in bacteria
    IPTG (367-93-1; animal free) induces β-galactosidase in bacteria.

  • KC7F2 | HIF-1alpha inhibitor
    KC7F2 is an inhibitor of HIF-1α (IC50 = 20 µM).1 It inhibited HIF-mediated transcription in cells derived from glioma, breast, and prostate cancers. The mechanism of action of KC7F2 is via down-regulation of...

  • Mithramycin A | Transcription inhibitor
    Mithramycin A (18378-89-7) inhibits DNA methyl transferase.1 A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibiting their expression.2...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Mupirocin | Antibiotic | CAS 12650-69-0
    Mupirocin (12650-69-0) is a topical antibiotic/antibacterial.1 It inhibits isoleucyl-tRNA synthase. High level mupirocin resistance was found in 8.2% of Staphylococcus aureus and 15.6% of coagulase-negative staphylococci...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Puromycin | Translation inhibitor | CAS 58-58-2
    Puromycin (58-58-2) is an aminonucleoside antibiotic derived from Streptomyces alboniger. It is a protein synthesis inhibitor that disrupts peptide transfer on ribosomes causing premature chain termination.1 It is an...

  • Focus Biomolecules supplier, chemical structure of Thiostrepton | Antibiotic and FOXM1 inhibitor | CAS 1393-48-2
    Thiostrepton (1393-48-2) is a novel cyclopeptide antibiotic. Blocks bacterial protein synthesis by inhibition of mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery as well as...

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