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PNU 282987 | nAChR agonist

CAS Number:
123464-89-1
Catalog Number:
10-4496
Activity:
nAChR agonist
Chemical Name:
N-(3R)-1-Azabicyclo[2.2.2}oct-3-yl-4-chlorobenzamide
Molecular Weight:
264.75
Molecular Formula:
C14H17ClN2O
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

PNU 282987 (CAS 123464-89-1) is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist (Ki = 26 nM).1  The a7 nAChR is a potential therapeutic target of cognitive deficits in diseases such as Alzheimer’s, Parkinson’s, schizophrenia, and attention deficit disorders – agonism of this receptor with PNU 282987 has shown potential to ameliorate these deficits.2-5

References/Citations:

1) Bodnar et al. (2005), Discovery and structure-activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors; J. Med. Chem. 48 905
2) Stuckenholz et al. (2013), The α7 nAChR agonist PNU-282987 reduces inflammation and MPTP-induced nigral dopaminergic cell loss in mice; J. Parkinsons Dis. 3 161
3) Vicens et al. (2013), Motor and anxiety effects of PNU-282987, an alpha7 nicotinic receptor agonist, and stress in an animal model of Alzheimer’s disease; Curr. Alzheimer Res. 10 516
4) Navarro et al. (2015), Alpha7 nicotinic receptor activation protects against oxidative stress via heme-oxygenase I induction; Biochem. Pharmacol. 97 473
5) McLean et al. (2016), Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders; Behav. Brain Res. 302 73

PNU 282987 | nAChR agonist is also available in the Cellular Metabolism Library.
CAS Number:
123464-89-1
Catalog Number:
10-4496
Activity:
nAChR agonist
Chemical Name:
N-(3R)-1-Azabicyclo[2.2.2}oct-3-yl-4-chlorobenzamide
Molecular Weight:
264.75
Molecular Formula:
C14H17ClN2O
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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