Roxatidine | Histamine H2 antagonist, antiulcer, anti-inflammatory

Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1 Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2 Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3 Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4

References/Citations
1) Mills and Wood (1989), The pharmacology of histamine H2-receptor antagonists; Methods Find. Exp. Clin. Phamracol., 11 Suppl. 1 87
2) Cho et al. (2011), Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macropages; J. Cell. Biochem., 112 3648
3) Imaeda et al. (2011), Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia; J. Gastroenterol., 46 1267
4) Ze et al. (2017), Roxatidine Attenuates Degradation of Extracellular Matrix; Biomed. Pharmacother., 95 1156

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

5 mg, 25 mg

Reviews

There are no reviews yet.

Be the first to review “Roxatidine | Histamine H2 antagonist, antiulcer, anti-inflammatory”

Your email address will not be published. Required fields are marked *

Product Inquiry

CAS:
78273-80-0
Catalog Number:
10-5046
Activity:
Histamine H2 antagonist, antiulcer, anti-inflammatory
Chemical Name:
2-hydroxy-N-(3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)acetamide
Molecular Weight:
306.40
Molecular Formula:
C17H26N2O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Colorless to pale yellow oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Roxatidine | Histamine H2 antagonist, antiulcer, anti-inflammatory

$90.00$360.00

CAS:
78273-80-0
Catalog Number:
10-5046
Activity:
Histamine H2 antagonist, antiulcer, anti-inflammatory
Chemical Name:
2-hydroxy-N-(3-(3-(piperidin-1-ylmethyl)phenoxy)propyl)acetamide
Molecular Weight:
306.40
Molecular Formula:
C17H26N2O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Colorless to pale yellow oil
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.