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  • Focus Biomolecules reagent supplier, chemical structure of 20(S)-Hydroxycholesterol | Smoothened activator | CAS 516-72-3
    20-(S)-Hydroxycholesterol (516-72-3) is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic...

  • Focus Biomolecules supplier, chemical structure of CUR 61414 | Hedgehog pathway antagonist | CAS 334998-26-6
    CUR 61414 (334998-26-6) is a novel Hedgehog signaling pathway inhibitor (IC50=100-200 nM). Selectively binds to Smo but not other GPCRs. CUR 61414 blocks the formation of and induces the regression of basaloid lesions in...

  • Focus Biomolecules cell signaling reagent supplier, structure Cyclopamine | Inhibits hedgehog signaling | CAS 4449-51-8
    Cyclopamine (4449-51-8) is a naturally occurring steroidal alkaloid with teratogenic activity. Blocks sonic hedgehog signaling by binding to smoothened. Antitumor activity. Cell Permeable. References/Citations1) Watkins et...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Jervine | Hedgehog pathway | CAS 469-59-0
    Jervine (469-59-0) is an inhibitor of Hedgehog signaling (IC50 = 0.5-0.7 μM). Binds directly to Smoothened (Smo)1. Inhibits the response of target tissues to Sonic hedgehog signaling2. Jervine induces COX-2 overexpression...

  • Focus Biomolecules cell signaling supplier, chemical structure of Purmorphamine | Smoothened activator | CAS 483367-10-8
    Purmorphamine (CAS  483367-10-8) induces osteogenesis in multipotent mesenchymal progenitor cells via activation of hedgehog signaling.1,2 Activation of hedgehog is achieved via direct targeting of Smoothened.3...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of SAG | Smoothened agonist | CAS 912545-86-9
    SAG (912545-86-9) is a smoothened agonist which bind directly to SMO and can block SMO inhibition by cyclopamine (Cat.# 10-1082). The conformation of SMO is altered by SAG binding which results in the accumulation of SMO in...

  • Focus Biomolecules supplier, chemical structure of Vismodegib | Sonic Hedgehog signaling pathway inhibitor | CAS 879085-55-9
    A potent and selective Hedgehog (Hh) pathway signaling inhibitor antagonizing SMO with a Ki of 1.3 nM).1 Alters intracellular Ca2+ homeostasis and inhibits growth of cisplatin-resistant lung cancer cells.2  Inhibits two...

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