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Growth Factors

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A83-01 | ALK inhibitor | CAS 909910-43-6
    A83-01 | ALK inhibitor
    $48.00
    A83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2 IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ.2 Inhibits...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of AAL-993 | VEGFR inhibitor | CAS 269390-77-4
    AAL-993 | VEGFR inhibitor
    $110.00
    AAL-993 (269390-77-4) inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-β, cKit, and CSF-1R are also inhibited at higher concentrations (IC50's 640 nM, 236 nM and 380 nM...

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  • Focus Biomolecules cell signaling supplier, chemical structure of Afatinib | EGFR, HER2 inhibitor | CAS 850140-72-6
    Afatinib | EGFR and HER2 inhibitor
    $85.00
    Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly selective inhibitor of mutant and wild-type EGFR (IC50= 0.5 nM) and HER2...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of ANA-12 | TrkB antagonist | CAS 219766-25-3
    ANA-12 | TrkB antagonist
    $75.00
    ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively...

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  • Focus Biomolecules cell signaling supplier, chemical structure of C8-Ceramide | Protein kinase activator | CAS 74713-59-0
    C8-Ceramide | Protein kinase activator
    $40.00
    C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1 Induces apoptosis.2 Reported to inhibit apoptosis and gap junction intercellular communication (GJIC) in rat liver...

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  • Focus Biomolecules cell signaling supplier, chemical structure of Cabozantinib | MET & VEGFR2 inhibitor | CAS 849217-68-1
    Cabozantinib | Met and VEGFR2 inhibitor
    $70.00
    Cabozantinib (849217-68-1) is a novel inhibitor of c-met and VEGFR2 kinase activity, IC50=3.5 nm and 35 pM respectively.1 Inhibits MET-activating kinase domain mutations Y1248H, D1246N or K1262R, IC50=3.8, 11.8 and 14.6 nM...

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  • Crenolanib | PDGFR and FLT3 inhibitor
    Crenolanib | PDGFR and FLT3 inhibitor
    $60.00
    Crenolanib (670220-88-9) is a potent inhibitor of PDGFR (Kd for α = 2.1 nM; β = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure Deltamethrin | Calcineurin inhibitor | CAS 52918-63-5
    Deltamethrin | Calcineurin inhibitor; displays neurotrophic activity
    $55.00
    Deltamethrin (52918-63-5) is reported to be an inhibitor of calcineurin (PP2B), IC50~100 pM1 but this activity has been disputed2. Markedly enhances the expression of BDNF in cultured rat cortical neurons and displays...

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  • Focus Biomolecules reagent supplier, chemical structure of Dienamide A2 | Novel cannabinoid CB2 agonist | CAS 24738-51-0
    Dienamide A2 | Novel cannabinoid CB2 agonist; antiinflammatory
    $60.00
    Dienamide A2 (24738-51-0) is an analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFα mRNA expression in human...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of DMPQ 2HCl | PDGFR inhibitor | CAS 137206-97-4
    DMPQ 2HCl | PDGFR inhibitor
    $62.00
    DMPQ 2HCl (137206-97-4) is a potent and selective inhibitor of PDGFRβ, IC50=80 nM. Greater than 100-fold more selective compared to EGFR, erB2, p56, PKA and PKC. Cell permeable. References/Citations1) Dolle et al...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Doramapimod | p38 MAPK inhibitor | CAS 285983-48-4
    Doramapimod | p38 MAPK inhibitor
    $50.00
    Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1 (IC50=18 nM). Displays anti-inflammatory activity2 but differential effects on...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure Dorsomorphin | AMPK inhibitor | CAS 866405-64-3
    Dorsomorphin | AMPK inhibitor
    $60.00
    Dorsomorphin (866405-64-3) is a potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Dovitinib | Kinase inhibitor | CAS 405169-16-6
    Dovitinib | Kinase inhibitor
    $75.00
    Dovitinib (405169-16-6) is a potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM).1 Active in cell...

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  • Focus Biomolecules supplier, chemical structure of Erlotinib HCl | EGFR Kinase inhibitor | CAS 183319-69-9
    Erlotinib HCl | EGFR Kinase inhibitor
    $35.00
    Erlotinib HCl (182219-93-9) is a potent inhibitor of EGFR tyrosine kinase (IC50 = 2 nM).1 Potent inhibitor of mutant JAK2-V617F.2 Weaker inhibitor of ErbB-2 kinase (Ki = 1 μM) ErbB-4 kinase (Ki = 1.5 μM).3 HDAC...

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  • Fruquintinib | Potent and selective inhibitor of VEGFR kinase
    Fruquintinib | Potent and selective inhibitor of VEGFR kinase
    $75.00
    Fruquintinib (1194506-26-7) is a potent and highly selective inhibitor of VEGFR kinase (IC50’s: VEGFR1= 33 nM, VEGFR2 = 35 nM, VEGFR3 = 0.5 nM).1 It potently inhibited VEGF/VEGFR signaling and cell proliferation in...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Gefitinib | EGFR kinase inhibitor | CAS 184475-35-2
    Gefitinib | EGFR kinase inhibitor
    $30.00
    Gefitinib (184475-35-2) is a potent and selective EGFR kinase inhibitor (IC50 = 23-79 nM)1. Inhibits EGFR autophosphorylation and inhibits tumor growth in vivo2. Enhances efficacy of cytotoxic agents3. Inhibits growth factor...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of GW-2580 | cFMS kinase inhibitor | CAS 870483-87-7
    GW-2580 | cFMS kinase inhibitor
    $72.00
    GW-2580 (870483-87-7) is a potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse...

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  • Focus Biomolecules cell signaling reagent supplier, structure of GW-441756 | NGFR kinase inhibitor | CAS 504433-23-2
    GW-441756 | NGFR kinase inhibitor
    $135.00
    GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM). References/Citations1) Wood et al. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Hypothemycin | MEK inhibitor | CAS 76958-67-3
    Hypothemycin | MEK inhibitor
    $200.00
    Hypothemycin (76958-67-3) is a potent and selective inhibitor of MEK.1-3 Acts via covalent binding to Cys residue.2 In cells, hypothemycin inhibits the MEK-ERK axis with sufficient selectivity to normalize transformed...

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  • Focus Biomolecules cell signaling supplier, chemical structure of Lapatinib (base) | EGFR & HER2 inhibitor | CAS 231277-92-2
    Lapatinib (base) | EGFR and HER2 inhibitor
    $50.00
    Lapatinib (231277-92-2) is a potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM).1  Clinically useful agent for treatment of breast cancer.2-3 Cell...

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