Growth Factors

AAL-993 (269390-77-4) inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-β, cKit, and CSF-1R are also inhibited at higher concentrations (IC50's 640 nM, 236 nM and 380 nM...

ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45.6 nM and 41.1 μM for the high and low affinity sites respectively...

Cabozantinib (849217-68-1) is a novel inhibitor of c-met and VEGFR2 kinase activity, IC50=3.5 nm and 35 pM respectively.1 Inhibits MET-activating kinase domain mutations Y1248H, D1246N or K1262R, IC50=3.8, 11.8 and 14.6 nM...

Dienamide A2 (24738-51-0) is an analog of the natural amides occurring in Echinacea which represent a new class of cannabinomimetic compounds. This class of compounds modulates TNFα mRNA expression in human...

Doramapimod (285983-48-4) potently and selectively inhibits p38 MAPK by simultaneously binding to the ATP-binding domain and an allosteric site.1 (IC50=18 nM). Displays anti-inflammatory activity2 but differential effects on...

Dovitinib (405169-16-6) is a potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM).1 Active in cell...

Gefitinib (184475-35-2) is a potent and selective EGFR kinase inhibitor (IC50 = 23-79 nM)1. Inhibits EGFR autophosphorylation and inhibits tumor growth in vivo2. Enhances efficacy of cytotoxic agents3. Inhibits growth factor...

GW-441756 (504433-23-2) is a potent and selective TrkA kinase inhibitor (IC50 = 2 nM). References/Citations1) Wood et al. (2004) Discovery and in vitro evaluation of potent TrkA kinase inhibitors: oxindole and aza-oxindoles...

Hypothemycin (76958-67-3) is a potent and selective inhibitor of MEK.1-3 Acts via covalent binding to Cys residue.2 In cells, hypothemycin inhibits the MEK-ERK axis with sufficient selectivity to normalize transformed...

A nonpeptide neurotrophic factor receptor p75 (p75NTR) agonist which promotes survival signaling in neurotrophin-responsive cells.1 Promotes functional recovery in a mouse model of spinal contusion injury.2 Protects...