Growth factors
Showing 1–12 of 56 results
-
ALK
A 83-01 | ALK inhibitor
A 83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2 IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad...$50.00 – $200.00 Select options -
Angiogenesis
AAL-993 | VEGFR inhibitor
AAL-993 (269390-77-4) inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-β, cKit, and CSF-1R are also inhi...$75.00 – $300.00 Select options -
Approved Drugs
Afatinib | EGFR and HER2 inhibitor
Afatinib (850140-72-6) is a clinically useful kinase inhibitor approved for the treatment of non-small cell lung cancer. It is a potent and highly ...$55.00 – $140.00 Select options -
Cancer
AG 1478 | EGFR kinase inhibitor
AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer ...$50.00 – $150.00 Select options -
Apoptosis
AG-1296 | PDGFR kinase inhibitor
AG-1296 (146535-11-7) is a potent inhibitor of PDGF receptor kinase (IC50 = 1 μM), c-kit and FGF kinase. Induces apoptosis in H526, small-cell lung...$60.00 – $260.00 Select options -
Cancer
AG-1517 HCl | EGFR kinase inhibitor
AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits ...$70.00 – $290.00 Select options -
Cancer
AG-879 | NGFR kinase inhibitor
AG-879 (148741-30-4) inhibits NGF-induced neurite growth in PC12 cells via selective inhibition of NGF receptor(pp140c-trk) autophosphorylation (IC...$70.00 – $280.00 Select options -
BDNF
ANA-12 | TrkB antagonist
ANA-12 (219755-25-3) is a TrkB receptor antagonist. Binds to two distinct receptor sites preventing activation by BDNF non-competitively, IC50 = 45...$75.00 – $220.00 Select options -
New Products
Belnacasan | ICE/caspase-1 inhibitor
Belnacasan (273404-37-8) is a prodrug of VRT-043198, a potent (Ki = 0.8 nM ICE/caspase-1; <0.6nM caspase-4) and selective inhibitor of interleuk...$45.00 – $160.00 Select options -
Apoptosis
C8-Ceramide | Protein kinase activator
C8-ceramide (74713-59-0) is a cell permeable ceramide analog. Stimulates ceramide-activated protein kinase.1 Induces apoptosis.2 Reported to inhibi...$40.00 – $155.00 Select options -
Cancer
Cabozantinib | Met and VEGFR2 inhibitor
Cabozantinib (849217-68-1) is a novel inhibitor of c-met and VEGFR2 kinase activity, IC50=3.5 nm and 35 pM respectively.1 Inhibits MET-activating k...$70.00 – $230.00 Select options -
Cancer
Crenolanib | PDGFR and FLT3 inhibitor
Crenolanib (670220-88-9) is a potent inhibitor of PDGFR (Kd for α = 2.1 nM; β = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor ...$60.00 – $195.00 Select options
