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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Dovitinib | Kinase inhibitor | CAS 405169-16-6
    Dovitinib (405169-16-6) is a potent kinase inhibitor. Inhibits FLT3 (IC50 = 1 nM), c-KIT (IC50 = 2 nM), FGFR (IC50 = 8 nM), VEGFR1/2/3 (IC50 = 10 nM), PDGFRβ (IC50 = 27 nM), and CSF-1R (IC50 = 36 nM).1 Active in cell...

  • NVP-BGJ398 | Pan-specific FGFR inhibitor
    NVP-BGJ398 (872511-34-1) is a potent and selective pan-FGFR inhibitor (IC50 = 0.9nM, 1.4 nM, 1.0 nM, and 60 nM for FGFR1,2,3,4 respectively).1  It has also been used in a mouse model of Achondroplasia (most common form...

  • PD173074 | FGFR inhibitor
    PD173074 (219580-11-7)is an inhibitor of FGFR tyrosine kinase, and to a lesser extent VEGFR1 (IC50 values are 5 nM, 22.5 nM and 100 nM for FGFR1, FGFR3 and VEGFR respectively). Inhibition of FGFR by PD173074 promotes stem...

  • SU-5402 | FGFR Phosphorylation inhibitor
    SU-5402 (215543-92-3) inhibits FGFR phosphorylation in vitro, in cell culture1, and in mouse tumor cell models2. SU-5402 can suppress ECP induced cardiomyocyte differentiation of P19CL6 embryonic carcinoma cells via an FGFR3...

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