Fruquintinib | Potent and selective inhibitor of VEGFR kinase

Fruquintinib (1194506-26-7) is a potent and highly selective inhibitor of VEGFR kinase (IC₅₀’s: VEGFR1= 33 nM, VEGFR2 = 35 nM, VEGFR3 = 0.5 nM).¹ It potently inhibited VEGF/VEGFR signaling and cell proliferation in HUVECs and HLECs and prevented angiogenesis in vitro. Fruquintinib is currently is several clinical trials against metastatic colorectal cancer² and nonsquamous non-small-cell lung cancer³.

References/Citations:

1) Sun et al. (2014) Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1,2,3 tyrosine kinases for cancer therapy; Cancer Biol. Ther. 15 1635
2) Li et al. (2018) Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial; JAMA 319 2486
3) Lu et al. (2018) Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Study of Fruquintinib After Two Prior Chemotherapy Regimens in Chinese Patients With Advanced Nonsquamous Non-Small-cell Lung Cancer; J. Clin. Oncol. 36 1207

Weight	0.01 mg
Dimensions	0.01 × 0.01 × 0.01 cm
Size:	5 mg, 25 mg

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CAS:

1194506-26-7

Catalog Number:

10-4784

Activity:

Potent and selective inhibitor of VEGFR kinase

Chemical Name:

6-(6,7-Dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide

Alternate Name:

HMPL-013

Molecular Weight:

393.40

Molecular Formula:

C₂₁H<sub19< sub=””>N₃O₄</sub19<>

Solubility:

Soluble in DMSO (up to 5 mg/ml).

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Shipping Code:

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Product Data Sheet

10-4784Fruquintinib__26744.1567644430.560.386

Fruquintinib | Potent and selective inhibitor of VEGFR kinase

Name: Fruquintinib | Potent and selective inhibitor of VEGFR kinase
SKU: 10-4784
Availability: InStock

$75.00 – $255.00

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SKU: 10-4784 Categories: Angiogenesis, Cancer, Growth factors, Growth factors, Highly selective inhibitors, Kinases, Kinases, New Products, VEGF, VEGFR, VEGFR Tags: 1194506-26-7, Fruquintinib | Potent and selective inhibitor of VEGFR kinase, Fruquintinib supplier

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Fruquintinib | Potent and selective inhibitor of VEGFR kinase