Fruquintinib | Potent and selective inhibitor of VEGFR kinase

Fruquintinib (1194506-26-7) is a potent and highly selective inhibitor of VEGFR kinase (IC50’s: VEGFR1= 33 nM, VEGFR2 = 35 nM, VEGFR3 = 0.5 nM).1 It potently inhibited VEGF/VEGFR signaling and cell proliferation in HUVECs and HLECs and prevented angiogenesis in vitro. Fruquintinib is currently is several clinical trials against metastatic colorectal cancer2 and nonsquamous non-small-cell lung cancer3.

References/Citations
1) Sun et al. (2014) Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1,2,3 tyrosine kinases for cancer therapy; Cancer Biol. Ther. 15 1635
2) Li et al. (2018) Effect of Fruquintinib vs Placebo on Overall Survival in Patients With Previously Treated Metastatic Colorectal Cancer: The FRESCO Randomized Clinical Trial; JAMA 319 2486
3) Lu et al. (2018) Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Study of Fruquintinib After Two Prior Chemotherapy Regimens in Chinese Patients With Advanced Nonsquamous Non-Small-cell Lung Cancer; J. Clin. Oncol. 36 1207

Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

5 mg, 25 mg

Reviews

There are no reviews yet.

Be the first to review “Fruquintinib | Potent and selective inhibitor of VEGFR kinase”

Your email address will not be published. Required fields are marked *

Product Inquiry

CAS:
1194506-26-7
Catalog Number:
10-4784
Activity:
Potent and selective inhibitor of VEGFR kinase
Chemical Name:
6-(6,7-Dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide
Alternate Name:
HMPL-013
Molecular Weight:
393.40
Molecular Formula:
C21H<sub19< sub=””>N3O4</sub19<>
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

Fruquintinib | Potent and selective inhibitor of VEGFR kinase

$75.00$255.00

CAS:
1194506-26-7
Catalog Number:
10-4784
Activity:
Potent and selective inhibitor of VEGFR kinase
Chemical Name:
6-(6,7-Dimethoxyquinazolin-4-yl)oxy-N,2-dimethyl-1-benzofuran-3-carboxamide
Alternate Name:
HMPL-013
Molecular Weight:
393.40
Molecular Formula:
C21H<sub19< sub=””>N3O4</sub19<>
Solubility:
Soluble in DMSO (up to 5 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
  • 5 mg
  • 25 mg
Clear
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.