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Product Details

GS-441524 | Antiviral/ active metabolite of remdesivir

GS-441524 is the parent nucleoside and active metabolite of the SARS-CoV2 drug remdesivir.  Displayed broad spectrum antiviral activity against HCV, YFV, DENV-2, influenza A, parainfluenza 3, and SARS-CoV.1 It has been suggested that GS-441524 is superior as an anti-SARS-CoV2 drug due to simplicity of preparation compared to remdesivir, lack of on-target liver toxicity, and the fact that remdesivir is prematurely hydrolysed to GS-441524 in human serum.2 Additionally, the enzymes that hydrolyze remdesivir to active metabolite GS-441524 are hardly expressed in lungs.

References/Citations

1) Cho, et al. (2012), Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides; Bioorg. Med. Chem. Lett. 22 2705
2) Yan and Muller (2020), Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment; ACS Med. Chem. Lett. 11 1361

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Catalog#  10-4485-0005

$45.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1191237-69-0
Catalog Number:
10-4485
Activity:
Antiviral/active metabolite of remdesivir
Chemical Name:
(2R,3R,4S,5R)-2-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
Molecular Weight:
291.27
Molecular Formula:
C12H13N5O4
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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