CID1067700 | Rab7 GTPase inhibitor

CID1067700 (314042-01-8) is a specific competitive inhibitor of nucleotide binding to Rab7, an endosome-localized small GTPase.1 It interferes with the Rab7-RILP interaction, locking the GTPase in an inactive conformation.2 Impairs B cell class switching and plasma cell survival dampening, the pathogenic autoantibody response in lupus.3 Inhibits the Arf-like small GTPase Arl8b, blocking cellular egress of ß-coronaviruses (SARS-CoV-2) which utilize a lysosomal exocytosis pathway.4

  1. Agola et al. (2012), A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition; ACS Chem. Biol., 7 1095
  2. Agola et al. (2015), Quantitative bead-based flow cytometry for assaying Rab7 GTPase interaction with the Rab-interacting lysosomal protein (RILP) effector protein; Methods Mol. Biol., 1298 331
  3. Lam et al. (2016), Small Molecule Inhibition of Rab7 Impairs B Cell Switching and Plasma Cell Survival To Dampen the Autoantibody response in Murine Lupus; Immunol.., 197 3792
  4. Ghosh et al. (2020), ß-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway; Cell, 183 1520
Weight 0.01 mg
Dimensions 0.01 × 0.01 × 0.01 cm
Size:

5 mg, 25 mg

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CAS:
314042-01-8
Catalog Number:
10-5401
Activity:
Rab7 GTPase inhibitor
Chemical Name:

2-[[(Benzoylamino)thioxomethyl]amino]-4,7-dihydro-5,5-dimethyl-5H-thieno[2,3-c]pyran-3-carboxylic acid; ML282

Molecular Weight:
390.48
Molecular Formula:
C18H18N2O4S2
Solubility:
Soluble in DMSO (up to 40 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC

NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

CID1067700 | Rab7 GTPase inhibitor

$65.00$240.00

CAS:
314042-01-8
Catalog Number:
10-5401
Activity:
Rab7 GTPase inhibitor
Chemical Name:

2-[[(Benzoylamino)thioxomethyl]amino]-4,7-dihydro-5,5-dimethyl-5H-thieno[2,3-c]pyran-3-carboxylic acid; ML282

Molecular Weight:
390.48
Molecular Formula:
C18H18N2O4S2
Solubility:
Soluble in DMSO (up to 40 mg/ml)
Physical Properties:
White solid
Purity:
98% TLC

NMR (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
  • 5 mg
  • 25 mg
Clear
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