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Immunology

The human immune system is composed of two major parts, the adaptive immune system and the innate immune system. The initial reaction to a pathogen involves the innate system, a non-specific response that involves inflammation, leukocytes, and the complement system. The adaptive immune system response is carried out by B cell and T cell lymphocytes. B cells are activated to secrete antibodies to the pathogen, present antigen, and secrete cytokines and various T cells kill target cells, activate macrophages, and stimulate B cells to produce antibodies. The adaptive immune system also creates immunological memory through memory B and T cells that provide enhanced protection to future infection.

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Immunosuppressants

  • FK-506

    FK-506 induced immunosuppression by inhibiting T cell proliferation

  • Mycophenolic acid

    Blocks the biosynthesis of guanine nucleotides via inhibition of 5'-monophosphate dehydrogenase

  • Caerulomycin

    Suppresses T cell activation and IFNγ secretion

  • Triptolide

    Triptolide is a potent immunosuppressive and antiinflammatory agent

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Cancer Immunotherapy

  • Epacadostat

    Epacadostat is a potent and selective inhibitor of IDO1

  • CPI-444

    CPI-444 is a potent and selective adenosine A2A antagonist

  • Motolimod

    Selective TLR8 agonist

  • SHP099

    SHP099 is an SHP2 phosphatase inhibitor that mediates PD-1 and CTLA immune checkpoint pathways

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STING

  • H151

    H151 is an inhibitor of STING in mouse and human cells

  • DMXAA

    DMXAA is a STING agonist in mice

  • 2',3'-cGAMP

    2',3'-cGAMP is an endogenous agonist of STING

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Toll-like receptors

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Chemokines

  • PF-4136309

    PF-4136309 is a potent and selective inhibitor of CCR2

  • Maraviroc

    Maraviroc is a potent and selective inhibitor of CCR5

  • Reparixin

    Reparixin is an allosteric CXCR1/2 antagonist

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