Modify Search
Select all
Products
Pages
Posts
Modify Search
Select all
Products
Pages
Posts
PhysioProcesses

Immunology

The human immune system is composed of two major parts, the adaptive immune system and the innate immune system. The initial reaction to a pathogen involves the innate system, a non-specific response that involves inflammation, leukocytes, and the complement system. The adaptive immune system response is carried out by B cell and T cell lymphocytes. B cells are activated to secrete antibodies to the pathogen, present antigen, and secrete cytokines and various T cells kill target cells, activate macrophages, and stimulate B cells to produce antibodies. The adaptive immune system also creates immunological memory through memory B and T cells that provide enhanced protection to future infection.

Adenosine A2A

Preladenant | Potent and selective adenosine A2A antagonist

CAS:
377727-87-2
Catalog Number:
10-4102
Chemical Name:
4-(Furan-2-yl)-10-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine
Alternate Name:
SCH 420814
Molecular Weight:
503.57
Molecular Formula:
C29H29N9O3
Solubility:
Soluble in DMSO (up to 5 mg/ml with warming).
Physical Properties:
Beige solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT

CPI-444 | Adenosine A2A receptor antagonist

CAS:
1202402-40-1
Catalog Number:
10-4101
Activity:
Adenosine A2A receptor antagonist
Chemical Name:
7-(5-Methylfuran-2-yl)-3-[[6-[[(3S)-oxolan-3-yl]oxymethyl]pyridine-2-yl]triazolo[4,5-d]pyrimidin-5-amine
Alternate Name:
Ciforadenant
Molecular Weight:
407.43
Molecular Formula:
C20H21N7O3
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Beige solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Cancer immunotherapy

CBL0137 | Inhibitor of the histone chaperone FACT

CBL0137 (1197996-80-7) is an anticancer agent that activates p53 and suppresses NF-kB via trapping of the FACT (facilitates chromatin transcription) complex, an important histone chaperone that mediates nucleosome

JPH203 | LAT1 inhibitor

CAS:
1597402-27-1
Catalog Number:
10-4464
Activity:
LAT1 inhibitor
Chemical Names:
(2S)-2-Amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid dihydrochloride
Alternate Name:
KYT-0353; Nanvuralant
Molecular Weight:
545.24
Molecular Formula:
C23H19Cl2N3O4·2HCl
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Pale orange/yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Luminespib | HSP90 inhibitor

CAS:
747412-49-3
Catalog Number:
10-4672
Activity:
HSP90 inhibitor
Chemical Names:
5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide
Alternate Name:
NVP-AUY922; VER-52296
Molecular Weight:
465.54
Molecular Formula:
C26H31N3O5
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
White solid
Purity:
99% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Cytokines

Sotrastaurin

CAS:
425637-18-9
Catalog Number:
10-4350
Molecular Weight:
438.48

Locostatin | RKIP/Raf-1 kinase disruptor

CAS:
133812-16-5
Catalog Number:
10-5381
Activity:
RKIP/Raf-1 kinase disruptor
Chemical Names:
(4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone; UIC-1005
Molecular Weight:
245.28
Molecular Formula:
C14H15O3
Solubility:
Soluble in DMSO (60 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Methotrexate | Dihydrofolate reductase inhibitor

CAS:
133073-73-1
Catalog Number:
10-1260
Activity:
Dihydrofolate reductase inhibitor
Chemical Names:
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Amethopterin; CL-14377; NSC740
Molecular Weight:
683.63
Molecular Formula:
C20H22N8O5·XH2O
Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
Yellow solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Glucocorticoid receptors

Dexamethasone | Apoptosis inducing glucocorticoid

CAS:
50-02-2
Catalog Number:
10-1134
Activity:
Apoptosis inducing glucocorticoid
Chemical Name:
(11α,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
Molecular Weight:
392.46
Molecular Formula:
C22H29FO5
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
Shipping Code:
RT

Histamine

Tranilast | Antiallergy agent

CAS:
53902-12-8
Catalog Number:
10-2234
Activity:
NFκB inhibitor
Alternate Names:
Rizaben
Chemical Name:
N-(3′,4′-Dimethoxycinnamoyl)anthranilic acid
Molecular Weight:
327.34
Molecular Formula:
C18H17NO5
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforrms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Astemizole | hERG channel blocker

CAS:
68844-77-9
Catalog Number:
10-1064
Activity:
hERG channel blocker
Chemical Name:
1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine
Molecular Weight:
457.58
Molecular Formula:
C28H31FN4O
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

IDO

NLG919 | IDO pathway inhibitor

CAS:
1402836-58-1
Catalog Number:
10-4564
Activity:
IDO pathway inhibitor
Chemical Name:
1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol
Molecular Weight:
282.39
Molecular Formula:
C18H22N2O
Solubility:
Soluble in DMSO (up to 15 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Epacadostat | IDO1 inhibitor

CAS:
1204669-58-8
Catalog Number:
10-4499
Activity:
IDO1 inhibitor/ Cancer immunotherapy enhancer
Chemical Name:
N-(3-Bromo-4-fluorophenyl)-N’-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide
Alternate Name:
INCB024360
Molecular Weight:
438.23
Molecular Formula:
C11H13BrFN7O4S
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

PF-06840003 | IDO1 inhibitor

CAS:
198474-05-4
Catalog Number:
10-4498
Activity:
IDO1 inhibitor/Cancer immunotherapy enhancer
Chemical Name:
3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione
Alternate Name:
EOS200271
Molecular Weight:
232.21
Molecular Formula:
C12H9FN2O2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Immunosuppressants

Halofuginone HBr | Prolyl-tRNA synthetase inhibitor

Halofuginone (64924-67-0) is a potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and

Kinases

LDC1267 | Inhibitor of TAM kinases

LDC1267 (1361030-48-9) is a potent and selective inhibitor of the TAM kinases Tyro3, Axl, and Mer (IC50s respectively: 8 nM, <5 nM, 29 nM).1 It was

Intelliscreen™ Highly-Selective Kinase Inhibitor Library

Catalog Number:
10-7001
Description:
81 highly selective inhibitors of various kinases.
Solubility:
DMSO
Supplied As:
DSMO solution @ 10mM
Storage Temperature:
-80°C
Stability:
Stable for up to 1 year when stored as supplied @ -80°C
Price:
$3 700.00

Leukotriene receptors

Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist

CAS:
103177-37-3
Catalog Number:
10-2441
Activity:
Leukotriene CysLT1 antagonist / GRP17 antagonist
Chemical Name:
N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzami
Alternate Names:
ONO-1078
Molecular Weight:
481.51
Molecular Formula:
C27H23N5O4
Solubility:
Soluble in DMSO (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

Zafirlukast | HSP70 inhibitor and leukotriene antagonist

CAS:
107753-78-6
Catalog Number:
10-1100
Activity:
Hsp70 inhibitor
Alternate Names:
ICI-204219
Molecular Weight:
575.69
Molecular Formula:
C31H33N3O6S
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White or pink solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

MK-571 | Cys LT1 antagonist

CAS:
115104-28-4
Catalog Number:
10-1039
Activity:
Cys LT1 antagonist
Alternate Names:
L-660711
Chemical Name:
5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid
Molecular Weight:
515.09
Molecular Formula:
C26H27ClN2O3S2
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Yellow solid
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Lipoxygenase

Baicalein | Inhibitor of protein tyrosine kinase in leukemia cells

CAS:
491-67-8
Catalog Number:
10-2773
Activity:
Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
Chemical Name:
5,6,7-Trihydroxyflavone
Molecular Weight:
270.24
Molecular Formula:
C15H10O5
Physical Properties:
Yellow or yellow-green solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.
Shipping Code:
RT

Zileuton | 5-LO inhibitor

CAS:
111406-87-2
Catalog Number:
10-1098
Activity:
5-LO inhibitor
Chemical Name:
N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
Molecular Weight:
236.29
Molecular Formula:
C11H12N2O2S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
>98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

MK-886 | FLAP inhibitor

CAS:
118414-82-7
Catalog Number:
10-1040
Activity:
FLAP inhibitor
Alternate Names:
L-663,536
Chemical Name:
3-[1-(4-Chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid
Molecular Weight:
472.08
Molecular Formula:
C27H34ClNO2S
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

NF-kB

2E151 | Vaccine co-adjuvant

Vaccine adjuvants are materials that enhance the magnitude and duration of protective immune responses, typically via pattern recognition receptors (PRR).  2E151 (2416963-37-4) is a co-adjuvant that

Tryptanthrin | Immunomodulator/IDO2 inhibitor

CAS:
13220-57-0
Catalog Number:
10-2228
Activity:
Immunomodulator; IDO2 inhibitor
Chemical Name:
Indolo(2,1-b)quinazoline-6,12-dione
Alternate Names:
NSC 349447; Couroupitine A
Molecular Weight:
248.24
Molecular Formula:
C15H8N2O2
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Rocaglamide | TNFalpha inhibitor

CAS:
84573-16-0
Catalog Number:
10-2484
Activity:
TNFalpha inhibitor
Molecular Weight:
505.57
Molecular Formula:
C29H31NO7
Solubility:
Soluble in DMSO or Ethanol
Physical Properties:
White solid supplied as a thin film on vial.
Purity:
97% by HPLC
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. Protect from exposure to light and moisture.
Shipping Code:
RT

Pattern recognition receptors

Loxoribine | TLR7 agonist

CAS:
121288-39-9
Catalog Number:
10-3780
Activity:
TLR7 agonist
Chemical Name:
7-Allyl-7,8-dihydro-8-oxoguanosine
Alternate Name:
RWJ-21757
Molecular Weight:
339.30
Molecular Formula:
C13H17N5O6
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
96% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Allopregnanolone | GABA-A positive allosteric modulator

CAS:
516-54-1
Catalog Number:
10-3489
Activity:
GABA-A positive allosteric modulator
Chemical Name:
(3α,5α)-3-Hydroxy-pregnan-20-one
Alternate Name:
(3α,5α)-Tetrahydroprogesterone; 3-OH-DHP
Molecular Weight:
318.49
Molecular Formula:
C21H34O2
Solubility:
Soluble in DMSO (up to 32 mg/ml) or in Ethanol (up to 32 mg/ml)
Physical Properties:
White or off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT

Imiquimod | TLR7 Agonist

CAS:
99011-02-6
Catalog Number:
10-4230
Alternate Name:
R837
Activity:
TLR7 agonist
Chemical Name:
1-(2-Methylpropyl)imidazo[4,5-c]quinolin-4-amine
Molecular Weight:
240.30
Molecular Formula:
C14H16N4
Solubility:
Soluble in DMSO (2 mg/ml with warming)
Physical Properties:
White solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Prostanoid receptors & prostaglandins

Grapiprant | EP4 Receptor antagonist

CAS:
415903-37-6
Catalog Number:
10-4006
Activity:
EP4 Receptor antagonist
Chemical Name:
1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea
Alternate Names:
CJ-023423; ARY-007
Molecular Weight:
491.61
Molecular Formula:
C26H29N5O3S
Solubility:
Soluble in DMSO (up to at least 10 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Prostaglandin E2 | Prostaglandin E (EP) receptor agonist

CAS:
363-24-6
Catalog Number:
10-1358
Activity:
Prostaglandin E (EP) receptor agonist
Alternate Names:
Dinoprost
Chemical Name:
(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid
Molecular Weight:
352.47
Molecular Formula:
C20H32O5
Solubility:
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (greater than 25 mg/ml).
Physical Properties:
White solid
Purity:
>98% by TLC
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
Blue Ice

Zileuton | 5-LO inhibitor

CAS:
111406-87-2
Catalog Number:
10-1098
Activity:
5-LO inhibitor
Chemical Name:
N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
Molecular Weight:
236.29
Molecular Formula:
C11H12N2O2S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
>98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT

RORγt

SR0987 |RORγt agonist

CAS:
303126-97-8
Catalog Number:
10-4008
Activity:
RORγt Agonist/Cancer immunotherapy enhancer
Chemical Name:
2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide
Molecular Weight:
397.70
Molecular Formula:
C16H10F6NO2
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

STING

SR-717 | STING agonist

CAS:
2375421-09-1
Catalog Number:
10-4850
Activity:
STING agonist
Chemical Names:
Lithium 2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate
Molecular Weight:
381.27
Molecular Formula:
C15H8F2N5O3·Li
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white solid
Purity:
>98% HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.
Shipping Code:
RT

RU.521 | cGAS Inhibitor

CAS:
2262452-06-0
Catalog Number:
10-4140
Activity:
cGAS Inhibitor
Chemical Name:

3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

Molecular Weight:
415.23
Molecular Formula:
C19H12Cl2N4O3
Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Off-white to pale pink solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT

CPI-455 | Lysine demethylase KDM5 inhibitor

CAS:
1628208-23-0
Catalog Number:
10-4035
Activity:
Lysine demethylase KDM5 inhibitor
Chemical Name:
7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile
Molecular Weight:
278.32
Molecular Formula:
C16H14N4O
Solubility:
Soluble in DMSO (up to at least 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

TGF-β

Halofuginone HBr | Prolyl-tRNA synthetase inhibitor

Halofuginone (64924-67-0) is a potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and

Other Immunology

ML401 | EBI2 (GPR183) antagonist

ML401 (1597489-14-9) is a potent antagonist of GPR183 (IC50 = 1.03 nM), also known as EBI2 or Epstein-Barr virus-induced gene 2.  ML401 inhibited  7α,25-dihydroxycholesterol-induced RS11846 cell

SR3335 | RORα partial inverse agonist

SR3335 (293753-05-6) is a selective RORα partial inverse agonist (IC50 = 480 nM) – displays no activity at RORß, RORγ, or FXR.1 It was able to suppress gluconeogenesis

Halofuginone HBr | Prolyl-tRNA synthetase inhibitor

Halofuginone (64924-67-0) is a potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and