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Immunology

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of 17-GMP-APA-GA | Modified Geldanamycin
    17-GMP-APA-GA | Modified Geldanamycin
    $185.00
    17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immunoconjugates, for example. References/Citations1) Mandler et al. (2004),...

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  • 2',3'-cGAMP | Endogenous STING agonist
    2',3'-cGAMP | Endogenous STING agonist
    $95.00
    2',3'-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist.1 Produced from ATP and GTP via the action of cGMP-AMP synthase (cGAS) which acts as a cytosolic DNA sensor.2,3 Induces autophagy...

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  • Focus Biomolecules supplier, chemical structure of 6-Thioguanine | Anticancer agent | Downregulates DNMT1 | CAS 154-42-7
    6-Thioguanine | Anticancer agent / Downregulates DNMT1
    $30.00
    6-Thioguanine (154-42-7) is a methyltransferase inhibitor.  After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A77 1726 | DHODH inhibitor | CAS 108605-62-5
    A77 1726 | DHODH inhibitor
    $45.00
    A77 1726 (108605-62-5) is a pyrimidine biosynthesis inhibitor and immunomodulator.1 Inhibits the mitochondrial dihydroorotate dehydrogenase (DHODH).2 Leflunomide (Cat.# 10-2369) is rapidly metabolized in human hepatocytes to...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A83-01 | ALK inhibitor | CAS 909910-43-6
    A83-01 | ALK inhibitor
    $48.00
    A83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2 IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ.2 Inhibits...

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  • Acalabrutinib | Highly selective BTK inhibitor
    Acalabrutinib | Highly selective BTK inhibitor
    $45.00
    Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3 nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved target selectivity (especially against TEC family kinases and EGFR)...

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  • Allopregnanolone | GABA-A positive allosteric modulator
    Allopregnanolone | GABA-A positive allosteric modulator
    $70.00
    Allopregnanolone (516-54-1) is an endogenous neurosteroid which acts as a positive allosteric modulator of GABAA receptors.1,2 Recently FDA approved (Brexanolone) for postpartum depression.3 Inhibits TLR4 receptor activation...

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  • Alpha-Mangostin | STING agonist (human)
    Alpha-Mangostin | STING agonist (human)
    $50.00
    α-Mangostin (6147-11-1) is a xanthone natural product that has historically been used in traditional folk medicine.1 It is a potent agonist of human STING (Stimulator of Interferon Genes) and also weakly activates...

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  • Focus Biomolecules cell signaling tech supplier, chemical structure Ambroxol HCl | Free radical scavenger | CAS 18683-91-5
    Ambroxol HCl | Free radical scavenger
    $50.00
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

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  • Focus Biomolecules supplier, Andrographolide | Induces mitochondrial-mediated apoptosis in lymphoma cells | CAS 5508-58-7
    Andrographolide | Induces mitochondrial -mediated apoptosis in lymphoma cells
    $34.00
    Andrographolide (5508-58-7) is the major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-apoptotic, anti-viral and anti-proliferative effects in vitro and in vivo...

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  • Focus Biomolecules supplier, chemical structure of Ascomycin | FKBP ligand immunosuppressant | CAS 11011-38-4
    Ascomycin | FKBP ligand immunosuppressant
    $35.00
    Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays antiinflammatory effects in skin diseases3. Cell permeable and...

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  • Focus Biomolecules cell signaling reagent supplier, structure of Astemizole | hERG channel blocker | CAS 68844-77-9
    Astemizole | hERG channel blocker
    $30.00
    Astemizole (68844-77-9) is an antagonist at the histamine H1 receptor. References/Citations1) Richards et al. (1984), Astemizole. A review of its pharmacodynamic properties and therapeutic efficacy; Drugs, 28 38 2) Laduron...

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  • AX-024 | Inhibitor of T cell antigen receptor (TCR)-dependent T cell activation
    AX-024 | Inhibitor of T cell antigen receptor (TCR)-dependent T cell activation
    $90.00
    AX-024 (1704801-24-0) is a potent (IC50 ~ 1 nM) and specific inhibitor of T cell antigen receptor (TCR)-dependent T cell activation. It inhibited neither B cell proliferation triggered by B cell antigen receptor (BCR), TLR4,...

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  • AZD7762 | Checkpoint kinase 1/2 inhibitor
    AZD7762 | Checkpoint kinase 1/2 inhibitor
    $60.00
    AZD7762 (860352-01-8, free base) is a potent and selective inhibitor of checkpoint kinases 1 and 2 (IC50 = 5 nM for both).1 It abrogates DNA damage-induced S and G2 checkpoints and enhances the efficacy of DNA damaging...

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  • Focus Biomolecules reagent supplier, chemical structure of Baicalein | Protein tyrosine kinase inhibitor | CAS 491-67-8
    Baicalein | Inhibitor of protein tyrosine kinase in leukemia (CEM cells)
    $40.00
    Baicalein (491-67-8) is an inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis1. Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been...

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BAY 11-7082 | IKK inhibitor | CAS 19542-67-7
    BAY 11-7082 | IKK inhibitor
    $60.00
    BAY 11-7082 (19542-67-7) inhibits cytokine-induced IκB-α phosphorylation via inhibition of IκB Kinase which results in inhibition of NFκB 1. Inhibits anchorage-independent growth of mammary...

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  • BI-D1870 | p90 ribosomal S6 kinase inhibitor
    BI-D1870 | p90 ribosomal S6 kinase inhibitor
    $90.00
    BI-D1870 (501437-28-1) is an inhibitor of p90 ribosomal S6 kinase (RSK; IC50’s = RSK1, 31 nM; RSK2, 24 nM; RSK3, 18 nM; RSK4, 15 nM) with selectivity over other AGC kinases.1 It protected mice from experimental...

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  • Biotinyl tyramide | Signal amplification reagent for immunoassays
    Biotinyl tyramide | Signal amplification reagent for immunoassays
    $40.00
    Reagent for use in catalyzed reporter deposition (CARD) signal amplification protocols in a variety of immunoassays in which, horseradish peroxidase catalyzed deposition of biotinyl tyramide is detected with labeled...

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  • BMS-202 | PD-1/PD-L1 inhibitor
    BMS-202 | PD-1/PD-L1 inhibitor
    $99.00
    BMS-202 (1675203-84-5) inhibits (IC50 = 18nM) formation of the PD-1/PD-L1 complex via binding to PD-L1 and inducing dimerization.1,2 References/Citations 1) Zak et al. (2016), Structural basis for small molecule...

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  • C-176 | STING Antagonist
    C-176 | STING Antagonist
    $40.00
    C-176 (314054-00-7) is an inhibitor of the signaling molecule STING in mouse cells. It covalently binds to Cys91 of STING preventing activation via blockade of palmitoylation at Cys91. Treatment of Trex-/- mice with C-176...

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