Immunology
Adenosine A2A Cancer immunotherapy Chemokines Cytokines Glucocorticoid receptors Histamine IDO Immunoconjugates Immunosuppressants Kinases Leukotriene receptors Lipoxygenase NF-kB Prostanoid receptors & prostaglandins Purinergic receptors RORgt STING TGF-b Toll-like receptors Other Immunology COX
Showing 1–12 of 133 results
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Cancer
17-GMP-APA-GA | Modified Geldanamycin
17-GMP-APA-GA is an analog of geldanamycin (Cat.# 10-1084) equipped with linker for coupling to proteins or antibodies for the preparation of immun...$140.00 – $500.00 Select options -
Immunology
2′,3′-cGAMP | Endogenous STING agonist
2',3'-cGAMP (CAS 1441190-66-4) is an endogenous STING (stimulator of interferon genes) agonist.1 Produced from ATP and GTP via the action of cGMP-A...$95.00 – $400.00 Select options -
Approved Drugs
6-Thioguanine | Anticancer agent / Downregulates DNMT1
6-Thioguanine (154-42-7) is a DNA methyltransferase inhibitor. After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransfe...$30.00 – $110.00 Select options -
ALK
A 83-01 | ALK inhibitor
A 83-01 (909910-43-6) is a potent and selective ALK4, 5 and 7 inhibitor.1,2 IC50 = 45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad...$50.00 – $200.00 Select options -
Cellular Metabolism
A77 1726 | DHODH inhibitor
A77 1726 (108605-62-5) is a pyrimidine biosynthesis inhibitor and immunomodulator.1 Inhibits the mitochondrial dihydroorotate dehydrogenase (DHODH)...$45.00 – $150.00 Select options -
New Products
Acalabrutinib | Highly selective BTK inhibitor
Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3 nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved t...$45.00 – $145.00 Select options -
Approved Drugs
Allopregnanolone | GABA-A positive allosteric modulator
Allopregnanolone (516-54-1) is an endogenous neurosteroid which acts as a positive allosteric modulator of GABAA receptors.1,2 Recently FDA approve...$70.00 – $280.00 Select options -
Antioxidants
Ambroxol HCl | Free radical scavenger
Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveol...$50.00 – $100.00 Select options -
Antivirals
Andrographolide | Induces mitochondrial-mediated apoptosis
Andrographolide (5508-58-7) is the major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-ap...$34.00 – $136.00 Select options -
New Products
Apilimod | IL-12 and 23/PIKfyve inhibitor
Apilimod (541550-19-0) is a potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 i...$45.00 – $160.00 Select options -
Calcineurin
Ascomycin | FKBP ligand/Immunosuppressant
Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascom...$35.00 – $120.00 Select options -
GPCRs
Astemizole | hERG channel blocker
Astemizole (68844-77-9) is an antagonist at the histamine H1 receptor. References/Citations: 1) Richards et al. (1984), Astemizole. A review ...$30.00 – $74.00 Select options
