Immunology

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Adenosine A2A

Preladenant | Potent and selective adenosine A2A antagonist

CAS:

377727-87-2

Catalog Number:

10-4102

Chemical Name:

4-(Furan-2-yl)-10-[2-[4-[4-(2-methoxyethoxy)phenyl]piperazin-1-yl]ethyl]-3,5,6,8,10,11-hexazatricyclo[7.3.0.0^2,6]dodeca-1(9),2,4,7,11-pentaen-7-amine

Alternate Name:

SCH 420814

Molecular Weight:

503.57

Molecular Formula:

C₂₉H₂₉N₉O₃

Solubility:

Soluble in DMSO (up to 5 mg/ml with warming).

Physical Properties:

Beige solid

Purity:

>98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

Shipping Code:

CPI-444 | Adenosine A2A receptor antagonist

CAS:

1202402-40-1

Catalog Number:

10-4101

Activity:

Adenosine A2A receptor antagonist

Chemical Name:

7-(5-Methylfuran-2-yl)-3-[[6-[[(3S)-oxolan-3-yl]oxymethyl]pyridine-2-yl]triazolo[4,5-d]pyrimidin-5-amine

Alternate Name:

Ciforadenant

Molecular Weight:

407.43

Molecular Formula:

C₂₀H₂₁N₇O₃

Solubility:

Soluble in DMSO (up to at least 25 mg/ml)

Physical Properties:

Beige solid

Purity:

98% by HPLC

NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Cancer immunotherapy

CBL0137 | Inhibitor of the histone chaperone FACT

CBL0137 (1197996-80-7) is an anticancer agent that activates p53 and suppresses NF-kB via trapping of the FACT (facilitates chromatin transcription) complex, an important histone chaperone that mediates nucleosome

JPH203 | LAT1 inhibitor

CAS:

1597402-27-1

Catalog Number:

10-4464

Activity:

LAT1 inhibitor

Chemical Names:

(2S)-2-Amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid dihydrochloride

Alternate Name:

KYT-0353; Nanvuralant

Molecular Weight:

545.24

Molecular Formula:

C₂₃H₁₉Cl₂N₃O₄·2HCl

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Pale orange/yellow solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Luminespib | HSP90 inhibitor

CAS:

747412-49-3

Catalog Number:

10-4672

Activity:

HSP90 inhibitor

Chemical Names:

5-(2,4-Dihydroxy-5-propan-2-ylphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]-1,2-oxazole-3-carboxamide

Alternate Name:

NVP-AUY922; VER-52296

Molecular Weight:

465.54

Molecular Formula:

C₂₆H₃₁N₃O₅

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

White solid

Purity:

99% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:

Cytokines

Sotrastaurin

CAS:

425637-18-9

Catalog Number:

10-4350

Molecular Weight:

438.48

Locostatin | RKIP/Raf-1 kinase disruptor

CAS:

133812-16-5

Catalog Number:

10-5381

Activity:

RKIP/Raf-1 kinase disruptor

Chemical Names:

(4S)-3-[(E)-But-2-enoyl]-4-benzyl-2-oxazolidinone; UIC-1005

Molecular Weight:

245.28

Molecular Formula:

C₁₄H₁₅O₃

Solubility:

Soluble in DMSO (60 mg/ml)

Physical Properties:

Off-white solid

Purity:

>98% TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Methotrexate | Dihydrofolate reductase inhibitor

CAS:

133073-73-1

Catalog Number:

10-1260

Activity:

Dihydrofolate reductase inhibitor

Chemical Names:

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid; Amethopterin; CL-14377; NSC740

Molecular Weight:

683.63

Molecular Formula:

C₂₀H₂₂N₈O₅·XH₂O

Solubility:

Soluble in DMSO (45 mg/ml)

Physical Properties:

Yellow solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Glucocorticoid receptors

Dexamethasone | Apoptosis inducing glucocorticoid

CAS:

50-02-2

Catalog Number:

10-1134

Activity:

Apoptosis inducing glucocorticoid

Chemical Name:

(11α,16α)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Molecular Weight:

392.46

Molecular Formula:

C₂₂H₂₉FO₅

Solubility:

Soluble in DMSO (up to 40 mg/ml).

Physical Properties:

White solid

Purity:

98%
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months

Shipping Code:

Histamine

Clemastine fumarate | Histamine H1 receptor antagonist/Enhances Remyelination

Clemastine fumarate (14976-57-9) is a histamine H1 antagonist with anti-muscarinic effects at the M1 receptor. Enhances remyelination in a mouse model of demyelination.1 Displays protective role

Tranilast | Antiallergy agent

CAS:

53902-12-8

Catalog Number:

10-2234

Activity:

NFκB inhibitor

Alternate Names:

Rizaben

Chemical Name:

N-(3′,4′-Dimethoxycinnamoyl)anthranilic acid

Molecular Weight:

327.34

Molecular Formula:

C₁₈H₁₇NO₅

Solubility:

Soluble in DMSO (up to 30 mg/ml).

Physical Properties:

Pale yellow solid

Purity:

98% by TLC
NMR (Conforrms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Shipping Code:

Astemizole | hERG channel blocker

CAS:

68844-77-9

Catalog Number:

10-1064

Activity:

hERG channel blocker

Chemical Name:

1-[(4-Fluorophenyl)methyl]-N-[1-[2-(4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine

Molecular Weight:

457.58

Molecular Formula:

C₂₈H₃₁FN₄O

Solubility:

Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).

Physical Properties:

White solid

Purity:

99% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:

IDO

NLG919 | IDO pathway inhibitor

CAS:

1402836-58-1

Catalog Number:

10-4564

Activity:

IDO pathway inhibitor

Chemical Name:

1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol

Molecular Weight:

282.39

Molecular Formula:

C₁₈H₂₂N₂O

Solubility:

Soluble in DMSO (up to 15 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Epacadostat | IDO1 inhibitor

CAS:

1204669-58-8

Catalog Number:

10-4499

Activity:

IDO1 inhibitor/ Cancer immunotherapy enhancer

Chemical Name:

N-(3-Bromo-4-fluorophenyl)-N’-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide

Alternate Name:

INCB024360

Molecular Weight:

438.23

Molecular Formula:

C₁₁H₁₃BrFN₇O₄S

Solubility:

Soluble in DMSO (up to at least 25 mg/ml)

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

PF-06840003 | IDO1 inhibitor

CAS:

198474-05-4

Catalog Number:

10-4498

Activity:

IDO1 inhibitor/Cancer immunotherapy enhancer

Chemical Name:

3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione

Alternate Name:

EOS200271

Molecular Weight:

232.21

Molecular Formula:

C₁₂H₉FN₂O₂

Solubility:

Soluble in DMSO (up to at least 25 mg/ml)

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Immunosuppressants

UCB9608 | Highly selective PI4KIIIß inhibitor

UCB9608 (1616413-96-7) is a potent (IC50 = 5 nM), highly selective, and orally bioavailable inhibitor of the phosphatidylinositol kinase PI4KIIIß.1 It acts as a potent immunosuppressive

Halofuginone HBr | Prolyl-tRNA synthetase inhibitor

Halofuginone (64924-67-0) is a potent and selective prolyl-tRNA synthetase (PRS) inhibitor (Ki=18.3 nM) derived from febrifugine.1 Also attenuates TGF-β signaling, including reversibly reducing Smad3 protein levels and

SLB1122168 | Sphingosine-1-phosphate transport inhibitor

SLB1122168 is a potent (IC50 = 94 nM) second generation sphingosine-1-phosphate transporter Spinster Homolog 2 (Spns2) inhibitor. In vivo, it significantly reduced circulating lymphocyte counts but

Kinases

LDC1267 | Inhibitor of TAM kinases

LDC1267 (1361030-48-9) is a potent and selective inhibitor of the TAM kinases Tyro3, Axl, and Mer (IC50s respectively: 8 nM, <5 nM, 29 nM).1 It was

JH-X-119-01 | Selective IRAK1 inhibitor

JH-X-119-01 (2227368-54-7) is a highly selective (only significantly inhibited YSK4 and MEK3 in a panel of over 300 kinases) and potent (IC50 = 9 nM) covalent

Intelliscreen™ Highly-Selective Kinase Inhibitor Library

Catalog Number:

10-7001

Description:

81 highly selective inhibitors of various kinases.

Solubility:

DMSO

Supplied As:

DSMO solution @ 10mM

Storage Temperature:

-80°C

Stability:

Stable for up to 1 year when stored as supplied @ -80°C

Price:

$3 700.00

Leukotriene receptors

Pranlukast | Leukotriene CysLT1 antagonist / GPR17 antagonist

CAS:

103177-37-3

Catalog Number:

10-2441

Activity:

Leukotriene CysLT1 antagonist / GRP17 antagonist

Chemical Name:

N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzami

Alternate Names:

ONO-1078

Molecular Weight:

481.51

Molecular Formula:

C₂₇H₂₃N₅O₄

Solubility:

Soluble in DMSO (up to 25 mg/ml)

Physical Properties:

White solid

Purity:

98%
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

Zafirlukast | HSP70 inhibitor and leukotriene antagonist

CAS:

107753-78-6

Catalog Number:

10-1100

Activity:

Hsp70 inhibitor

Alternate Names:

ICI-204219

Molecular Weight:

575.69

Molecular Formula:

C₃₁H₃₃N₃O₆S

Solubility:

Soluble in DMSO (up to 10 mg/ml).

Physical Properties:

White or pink solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 2 years as supplied. Protect from exposure to moisture. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

MK-571 | Cys LT1 antagonist

CAS:

115104-28-4

Catalog Number:

10-1039

Activity:

Cys LT1 antagonist

Alternate Names:

L-660711

Chemical Name:

5-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)phenyl)-8-dimethylcarbamyl-4,6-dithiaoctanoic acid

Molecular Weight:

515.09

Molecular Formula:

C₂₆H₂₇ClN₂O₃S₂

Solubility:

Soluble in DMSO (up to 50 mg/ml).

Physical Properties:

Yellow solid

Purity:

95% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:

Lipoxygenase

Baicalein | Inhibitor of protein tyrosine kinase in leukemia cells

CAS:

491-67-8

Catalog Number:

10-2773

Activity:

Inhibitor of protein tyrosine kinase in leukemia (CEM cells)

Chemical Name:

5,6,7-Trihydroxyflavone

Molecular Weight:

270.24

Molecular Formula:

C₁₅H₁₀O₅

Physical Properties:

Yellow or yellow-green solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 week.

Shipping Code:

Zileuton | 5-LO inhibitor

CAS:

111406-87-2

Catalog Number:

10-1098

Activity:

5-LO inhibitor

Chemical Name:

N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea

Molecular Weight:

236.29

Molecular Formula:

C₁₁H12N₂O₂S

Solubility:

Soluble in DMSO (up to 25 mg/ml).

Physical Properties:

White solid

Purity:

>98%
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

MK-886 | FLAP inhibitor

CAS:

118414-82-7

Catalog Number:

10-1040

Activity:

FLAP inhibitor

Alternate Names:

L-663,536

Chemical Name:

3-[1-(4-Chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid

Molecular Weight:

472.08

Molecular Formula:

C₂₇H₃₄ClNO₂S

Solubility:

Soluble in DMSO (up to 40 mg/ml).

Physical Properties:

White solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

Stability:

Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

Shipping Code:

NF-kB

2E151 | Vaccine co-adjuvant

Vaccine adjuvants are materials that enhance the magnitude and duration of protective immune responses, typically via pattern recognition receptors (PRR). 2E151 (2416963-37-4) is a co-adjuvant that

Tryptanthrin | Immunomodulator/IDO2 inhibitor

CAS:

13220-57-0

Catalog Number:

10-2228

Activity:

Immunomodulator; IDO2 inhibitor

Chemical Name:

Indolo(2,1-b)quinazoline-6,12-dione

Alternate Names:

NSC 349447; Couroupitine A

Molecular Weight:

248.24

Molecular Formula:

C₁₅H₈N₂O₂

Solubility:

Soluble in DMSO (up to 30 mg/ml)

Physical Properties:

Yellow solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Rocaglamide | TNFalpha inhibitor

CAS:

84573-16-0

Catalog Number:

10-2484

Activity:

TNFalpha inhibitor

Molecular Weight:

505.57

Molecular Formula:

C₂₉H₃₁NO₇

Solubility:

Soluble in DMSO or Ethanol

Physical Properties:

White solid supplied as a thin film on vial.

Purity:

97% by HPLC

Storage Temperature:

-20°C

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. Protect from exposure to light and moisture.

Shipping Code:

P2X/P2Y

Pattern recognition receptors

Loxoribine | TLR7 agonist

CAS:

121288-39-9

Catalog Number:

10-3780

Activity:

TLR7 agonist

Chemical Name:

7-Allyl-7,8-dihydro-8-oxoguanosine

Alternate Name:

RWJ-21757

Molecular Weight:

339.30

Molecular Formula:

C₁₃H₁₇N₅O₆

Solubility:

Soluble in DMSO (up to 25 mg/ml).

Physical Properties:

White solid

Purity:

96% by TLC
NMR (Conforms)

Storage Temperature:

-20°

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Shipping Code:

Allopregnanolone | GABA-A positive allosteric modulator

CAS:

516-54-1

Catalog Number:

10-3489

Activity:

GABA-A positive allosteric modulator

Chemical Name:

(3α,5α)-3-Hydroxy-pregnan-20-one

Alternate Name:

(3α,5α)-Tetrahydroprogesterone; 3-OH-DHP

Molecular Weight:

318.49

Molecular Formula:

C₂₁H₃₄O₂

Solubility:

Soluble in DMSO (up to 32 mg/ml) or in Ethanol (up to 32 mg/ml)

Physical Properties:

White or off-white solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20° (des.)

Stability:

Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

Shipping Code:

Imiquimod | TLR7 Agonist

CAS:

99011-02-6

Catalog Number:

10-4230

Alternate Name:

R837

Activity:

TLR7 agonist

Chemical Name:

1-(2-Methylpropyl)imidazo[4,5-c]quinolin-4-amine

Molecular Weight:

240.30

Molecular Formula:

C₁₄H₁₆N₄

Solubility:

Soluble in DMSO (2 mg/ml with warming)

Physical Properties:

White solid

Purity:

>98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Prostanoid receptors & prostaglandins

Grapiprant | EP4 Receptor antagonist

CAS:

415903-37-6

Catalog Number:

10-4006

Activity:

EP4 Receptor antagonist

Chemical Name:

1—[2-[4-(2-Ethyl-4,6-dimethylimidazo[4,5-c]pyridine-1-yl)phenyl]ethyl]-3-(4-methylphenyl)sulfonylurea

Alternate Names:

CJ-023423; ARY-007

Molecular Weight:

491.61

Molecular Formula:

C₂₆H₂₉N₅O₃S

Solubility:

Soluble in DMSO (up to at least 10 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

Prostaglandin E2 | Prostaglandin E (EP) receptor agonist

CAS:

363-24-6

Catalog Number:

10-1358

Activity:

Prostaglandin E (EP) receptor agonist

Alternate Names:

Dinoprost

Chemical Name:

(5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid

Molecular Weight:

352.47

Molecular Formula:

C₂₀H₃₂O₅

Solubility:

Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (greater than 25 mg/ml).

Physical Properties:

White solid

Purity:

>98% by TLC

Storage Temperature:

-20°

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Shipping Code:

Blue Ice

Zileuton | 5-LO inhibitor

CAS:

111406-87-2

Catalog Number:

10-1098

Activity:

5-LO inhibitor

Chemical Name:

N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea

Molecular Weight:

236.29

Molecular Formula:

C₁₁H12N₂O₂S

Solubility:

Soluble in DMSO (up to 25 mg/ml).

Physical Properties:

White solid

Purity:

>98%
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Shipping Code:

RORγt

SR0987 |RORγt agonist

CAS:

303126-97-8

Catalog Number:

10-4008

Activity:

RORγt Agonist/Cancer immunotherapy enhancer

Chemical Name:

2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide

Molecular Weight:

397.70

Molecular Formula:

C₁₆H₁₀F₆NO₂

Solubility:

Soluble in DMSO (up to at least 25 mg/ml) and Ethanol (up to at least 25 mg/ml)

Physical Properties:

White solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Shipping Code:

STING

SR-717 | STING agonist

CAS:

2375421-09-1

Catalog Number:

10-4850

Activity:

STING agonist

Chemical Names:

Lithium 2-(6-(1H-Imidazol-1-yl)pyridazine-3-carboxamido)-4,5-difluorobenzoate

Molecular Weight:

381.27

Molecular Formula:

C₁₅H₈F₂N₅O₃·Li

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white solid

Purity:

>98% HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month1.

Shipping Code:

RU.521 | cGAS Inhibitor

CAS:

2262452-06-0

Catalog Number:

10-4140

Activity:

cGAS Inhibitor

Chemical Name:

3-[1-(6,7-Dichloro-1H-benzimidazol-2-yl)-5-hydroxy-3-methylpyrazol-4-yl]-3H-isobenzofuran-1-one

Molecular Weight:

415.23

Molecular Formula:

C₁₉H₁₂Cl₂N₄O₃

Solubility:

Soluble in DMSO (>25 mg/ml)

Physical Properties:

Off-white to pale pink solid

Purity:

>98% by TLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Shipping Code:

CPI-455 | Lysine demethylase KDM5 inhibitor

CAS:

1628208-23-0

Catalog Number:

10-4035

Activity:

Lysine demethylase KDM5 inhibitor

Chemical Name:

7-Oxo-5-phenyl-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile

Molecular Weight:

278.32

Molecular Formula:

C₁₆H₁₄N₄O

Solubility:

Soluble in DMSO (up to at least 25 mg/ml)

Physical Properties:

Off-white solid

Purity:

98% by HPLC
NMR (Conforms)

Storage Temperature:

-20°C

Stability:

Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Shipping Code:

ADC warheads

Adenosine A2A

Cancer immunotherapy

Cytokines

Glucocorticoid receptors

Histamine

IDO

Immunosuppressants

Kinases

Leukotriene receptors

Lipoxygenase

NF-kB

P2X/P2Y

Pattern recognition receptors

Prostanoid receptors & prostaglandins

RORγt

STING

TGF-β

Other Immunology

Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21

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Plymouth Meeting, PA USA
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