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immunosuppressants

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  • Focus Biomolecules supplier, chemical structure of 6-Thioguanine | Anticancer agent | Downregulates DNMT1 | CAS 154-42-7
    $30.00
    6-Thioguanine (154-42-7) is a methyltransferase inhibitor.  After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of A77 1726 | DHODH inhibitor | CAS 108605-62-5
    $45.00
    A77 1726 (108605-62-5) is a pyrimidine biosynthesis inhibitor and immunomodulator.1 Inhibits the mitochondrial dihydroorotate dehydrogenase (DHODH).2 Leflunomide (Cat.# 10-2369) is rapidly metabolized in human hepatocytes to...

  • Focus Biomolecules supplier, chemical structure of Ascomycin | FKBP ligand immunosuppressant | CAS 11011-38-4
    $35.00
    Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays antiinflammatory effects in skin diseases3. Cell permeable and...

  • Focus Biomolecules supplier, chemical structure Caerulomycin A | Blocks STAT1 signaling / Immunosuppressant | CAS 21802-37-9
    $80.00
    Caerulomycin A (21802-37-9) chemically novel and potent immunosuppressive agent. Suppresses T cell activation and IFN7gamma; secretion in vitro and in vivo1. Caerulomycin A induces expansion of regulatory T cells by via...

  • Focus Biomolecules supplier, structure Cyclosporin A | Inhibits mitochondrial permeability pore opening | CAS 59865-13-3
    $50.00
    Cyclosporin A (59865-16-6) is an immunosupressant. The CsA-cyclophilin complex binds to and inhibits calcineurin, a type 2B phosphatase. Cell permeable. References/Citations1) Liu et al. (1993), FK506 and cyclosporin:...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Everolimus | mTOR inhibitor | CAS 159351-69-6
    $60.00
    Everolimus (159351-69-6) is a semisynthetic analog of rapamycin (Cat.# 10-1104) with potent immunosuppressive activity.1 Inhibits mTOR.2 Everolimus is a clinically useful immunosuppressant.3 References/Citations1)...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of FK-506 | FKBP inhibitor | CAS 104987-11-3
    $48.00
    FK-506 (104987-11-3) induces immunosuppression by inhibiting T cell proliferation. Inhibits FKBP12 and calcineurin (IC50 ~ 1 nM). Cell permeable. References/Citations1) Yu et al. (2006), Effects of cyclosporine A, FK506 and...

  • Helenalin | NFkB inhibitor
    $238.00
    Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1 and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms3...

  • IQ-1S | JNK3 inhibitor
    $40.00
    IQ-1S (1421610-21-0) is a JNK3 inhibitor (Kd = 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Displays anti-inflammatory and immunosuppresive activity. Inhibits LPS-induced proinflammatory cytokine and nitric...

  • Focus Biomolecules supplier, chemical structure of Kynurenine (L) | Endogenous AhR agonist | CAS 2922-83-0
    $38.00
    Kynurenine (2922-83-0) is a tryptophan catabolite.1 Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Leflunomide | Immunosuppressant | CAS 75706-12-6
    $40.00
    Leflunomide (75706-12-6) pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2; however...

  • Focus Biomolecules supplier, chemical structure of Mycophenolate mofetil | Immunomodulator | CAS 128794-94-5
    $35.00
    Mycophenolate mofetil (128794-94-5) is a mycophenolic acid prodrug. Immunosuppressive agent useful in prevention of organ allograft rejection.1 Is metabolized to mycophenolic acid in vivo  which acts by inhibiting...

  • Focus Biomolecules supplier, chemical structure of Mycophenolic acid | Immunosuppressant | CAS 24280-93-1
    $40.00
    Mycophenolic acid (24280-93-1) is an immunomodulator1 that blocks the biosynthesis of guanine nucleotides via inhibition of inosine 5'-monophosphate dehydrogenase. This in turn suppresses the production of proinflammatory...

  • Focus Biomolecules supplier, chemical structure of Myriocin | Blocks sphingolipid biosynthesis | CAS 35891-70-4
    $65.00
    Myriocin (35891-70-4) is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 Myriocin was found to suppress melanoma cell...

  • Focus Biomolecules cell signaling reagent supplier, structure of Palmitoylethanolamine | GPR-55 agonist | CAS 544-31-0
    $60.00
    Palmitoylethanolamide (544-31-0) is an endogenous cannabinoid. Weak ligand for CB1 (Ki= 23.8 μM) and CB2 (Ki = 13.9 μM) receptors. Inhibits fatty acid amide hydrolase (FAAH) ((IC50 = 5.1 μM). Modulates mast cell...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Rapamycin | mTOR inhibitor | CAS 53123-88-9
    $48.00
    Rapamycin (53123-88-9) is a clinically useful immunosuppressant. Inhibits the response to interleukin-2 blocking activation of T- and B-cells.1 Rapamycin forms a complex with cytosolic FK-binding protein 12 (FKB12) that...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Rocaglamide | NFkB inhibitor | CAS 84573-16-0
    $60.00
    Rocaglamide (84573-16-0) is a potent inhibitor of NFκB in T-lymphocytes with almost complete inhibition at 200nM.1  It was able to completely inhibit IL-4 and IFN-γ production and suppress 60-85% of IL-2 and...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of THI | Immunomodulator | CAS 94944-70-4
    $95.00
    THI (94944-70-4) was identified as a biologically active impurity in caramel food coloring.1 It is a potent inhibitor of sphingosine-1-phosphate (S1P) lyase.2 It disrupts lymphocyte egress from lymphoid tissue by interfering...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Tofacitinib | JAK inhibitor | CAS 477600-75-2
    $60.00
    Tofacitinib (477600-75-2) is a potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively.1 Displays potent antiinflammatory2 and immunosuppressant3 activity. Promotes a white-to-brown metabolic...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Triptolide | Immunosuppressant | CAS 38748-32-2
    $35.00
    Triptolide (38748-32-2) possesses potent immunosuppressive and anti-inflammatory activity.  Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH.1...

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