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Kinases

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  • Acalabrutinib | Highly selective BTK inhibitor
    $45.00
    Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK).1 Improved target selectivity (especially against TEC family kinases and EGFR)...

  • BI-D1870 | p90 ribosomal S6 kinase inhibitor
    $90.00
    BI-D1870 (501437-28-1) is an inhibitor of p90 ribosomal S6 kinase (RSK; IC50’s = RSK1, 31 nM; RSK2, 24 nM; RSK3, 18 nM; RSK4, 15 nM) with selectivity over other AGC kinases.1 It protected mice from experimental...

  • Duvelisib | PI3Kdelta/gamma inhibitor
    $75.00
    Duvelisib (1201438-56-3) is a potent and selective (IC50’s: PI3Kα = 1602nM, PI3Kβ = 85nM, PI3Kδ= 2.5nM, PI3Kγ = 27nM) dual PI3Kδ/γ inhibitor.1 It inhibits B and T cell proliferation,...

  • Ibrutinib | BTK inhibitor
    $40.00
    Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR).1 Ibrutinib also potently inhibits several other...

  • Focus Biomolecules supplier, chemical structure of SB 202190 | p38 MAP kinase inhibitor | CAS 152121-30-7
    $30.00
    SB 202190 (152121-30-7) is a potent and selective p38 MAP kinase inhibitor acting at the ATP site.1 Selectively inhibits the p38α and β isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38β2...

  • Focus Biomolecules supplier, chemical structure of SB 203580 | p38 MAP kinase inhibitor | CAS 152121-47-6
    $75.00
    SB 203580 (152121-47-6) is a potent and selective inhibitor of p38 MAP kinase, IC50=50 and 500 nM for p38 and p38β2 respectively. No other kinases (in a panel of 30) were significantly inhibited including p38γ and...

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