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NF-kB

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  • Focus Biomolecules supplier, Andrographolide | Induces mitochondrial-mediated apoptosis in lymphoma cells | CAS 5508-58-7
    $34.00
    Andrographolide (5508-58-7) is the major bioactive component of the medicinal plant Andrographis paniculate. Demonstrates anti-inflammatory anti-apoptotic, anti-viral and anti-proliferative effects in vitro and in vivo...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of BAY 11-7082 | IKK inhibitor | CAS 19542-67-7
    $70.00
    BAY 11-7082 (19542-67-7) selectively inhibits TNFα-induced phosphorylation of IκB-α leading to decreased nuclear NF-κB and decreased adhesion molecule expression without affecting constitutive...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of CAPE | Inhibits NFkB activation | CAS 104594-70-9
    $30.00
    CAPE (104594-70-9) is an antioxidant that inhibits NFκB activation and the growth of transformed cells. CAPE inhibits lipid peroxidation and displays antiinflammatory activity. Cell permeable. References/Citations1)...

  • Cardamonin | NFkB inhibitor
    $50.00
    Cardamonin (19309-14-9) inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation1,2. Cardamonin displays...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Celastrol | Proteasome inhibitor | CAS 34157-83-0
    $50.00
    Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM).  It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin...

  • DMAPT | NFkB inhibitor
    $45.00
    DMAPT (870677-05-7) is a water soluble analog of the natural plant product parthenolide (Cat.# 10-2096) which suppresses in vivo tumor growth of two tobacco-associated neoplasms, lung and bladder cancer. It inhibits...

  • Helenalin | NFkB inhibitor
    $238.00
    Helenalin (6754-13-8) is a novel sesquiterpene lactone which inhibits NFκB1 and displays potent anti-inflammatory activity2. It suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms3...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Oxaprozin | NFkB inhibitor | CAS 21256-18-8
    $70.00
    Oxaprozin (21256-18-8) is a clinically useful non-steroidal anti-inflammatory drug.1 In addition to typical NSAID COX inhibition, oxaprozin may also exert anti-inflammatory effects via inhibition of the Akt/IKK/NF-κB...

  • Focus Biomolecules cell signaling reagent supplier, structure of Phytosphingosine | Natural sphingolipid | CAS 554-62-1
    $45.00
    Phytosphingosine (554-62-1) displays antibacterial activity.1 Can be taken up by E. coli and S. aureus and induce ultrastructural damage.2 References/Citations1) Fischer et al. (2012), Antibacterial activity of...

  • SirtAct | Sirt1 activator
    $80.00
    SirtAct (839699-72-8) is a Sirt1 activator (233% at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells1. SIRT1 stimulation by SirtAct leads to decreased tissue factor...

  • Focus Biomolecules cell signaling reagent supplier, Sivelestat | Leukocyte elastase inhibitor | CAS 127373-66-4
    $50.00
    Sivelestat (127373-66-4) is a potent and selective leukocyte elastase inhibitor, IC50 = 44 nM1. Displays no activity at a variety of other proteases. Inhibits NF-κB activation2 and LTB4-induced neutrophil migration in...

  • Sulfasalazine | Anti-inflammatory / antibiotic
    $20.00
    Sulfasalazine (599-79-1) is an approved drug with diverse potential applications. Sulfasalzine is a clinically useful agent for the treatment of colitis and ileocolitis.1 It is metabolized by intestinal bacteria to release...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of WY-14643 | PPARŒ± agonist | CAS 50892-23-4
    $60.00
    WY-14643 (50892-23-4) is a selective PPARα agonist (EC50=0.63, 32 and >100 µM for PPARα,γ and δ, respectively).1  Displays anti-inflammatory activity2 and reduces LPS-induced...

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