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  • Focus Biomolecules cell signaling reagent supplier, structure of Bestatin HCl | Aminopeptidase inhibitor | CAS 65391-42-6
    $55.00
    Bestatin HCl (65391-42-6) inhibits leucine aminopeptidase and aminopeptidases B and N. Inhibits leukotriene A4 hydrolase. Displays immunostimulant activity via activation of macrophages and T lymphocytes. Displays antitumor...

  • Biotinyl tyramide | Signal amplification reagent for immunoassays
    $40.00
    Reagent for use in catalyzed reporter deposition (CARD) signal amplification protocols in a variety of immunoassays in which, horseradish peroxidase catalyzed deposition of biotinyl tyramide is detected with labeled...

  • Cycloheximide-N-ethylethanoate | FKBP12 inhibitor
    $65.00
    FKBP12 inhibitor (IC50=4.4 µM) with neuroregenerative properties. Does not inhibit protein synthesis (as does cycloheximide).1 Mimics a helical peptide in target proteins for binding to the immunophillin Mip homolog,...

  • Focus Biomolecules supplier, chemical structure of FTY720 HCl | Sphingosine-1-phosphate receptor agonist | CAS 162359-56-0
    $45.00
    FTY720 HCl (162359-56-0) is an analog of sphingosine (Cat.# 10-2287) which, when taken up into cells, is phosphorylated and acts as an agonist at sphingosine-1-phosphate receptors (S1P1/3).1 Potently inhibits regulatory...

  • Ingenol-3-angelate | PKC activator
    $110.00
    Ingenol-3-angelate (75567-37-2) is a selective activator of protein kinase C which displays antileukemic activity mediated via PKCδ.1 In contrast, it provides a strong survival signal to resting and activated...

  • IPI-549 | Selective PI3Kgamma inhibitor / Immuno-oncology agent
    $65.00
    IPI-549 (1693758-51-8) is a potent and highly selective inhibitor of PI3K-γ in both biochemical (IC50 = 16 nM) and cellular (IC50 = 12.2 nM) assays.1 Macrophage PI3K-γ has been found to be a critical switch...

  • Leflunomide | Immunosuppressant
    $40.00
    Leflunomide (75706-12-6) pyrimidine biosynthesis inhibitor DMARD (disease-modifying antirheumatic drug)1. Displays immunomodulatory activity inhibiting the mitochondrial enzyme dihydroorotate dehydrogenase (DHODH)2; however...

  • Lenalidomide | Immunomodulator
    $35.00
    Lenalidomide (191732-72-6) is a thalidomide analog which, like thalidomide1, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2...

  • Lisofylline (racemic) | Anti-diabetic and Antiinflammatory agent
    $50.00
    Lisofylline (6493-06-7, racemic) displays anti-inflammatory activity. Regulates immune cell function and autoimmune response by inhibition of IL-12 signalling and cytokine production1. Protects pancreatic beta cells and...

  • Sitravatinib | Multikinase inhibitor / Immuno-oncology agent
    $50.00
    Sitravatinib (1123837-84-2) is a broad spectrum receptor tyrosine kinase inhibitor. Its targets include Axl, c-Met, PDGFR, VEGFR, Ephrin receptor family, and FLT3 among others at nanomolar levels.1 Sitravatinib has been...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Tofacitinib | JAK inhibitor | CAS 477600-75-2
    $60.00
    Tofacitinib (477600-75-2) is a potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2 and JAK1 respectively.1 Displays potent antiinflammatory2 and immunosuppressant3 activity. Promotes a white-to-brown metabolic...

  • Focus Biomolecules supplier, chemical structure of WEB-2086 | PAF receptor antagonist | CAS 105219-56-5
    $40.00
    WEB-2086 (105219-56-5) is a potent and selective antagonist of the platelet activating factor (PAF) receptor (Ki = 16.3 nM).1 Displays an activity profile which includes antiinflammatory, antiangiogenesis and anticancer...

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