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Prostanoid receptors and Prostaglandins

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  • Grapiprant | EP4 Receptor antagonist
    Grapiprant (415903-37-6) is a potent (Ki = 13 nM for human and 20 nM for rat) and selective prostaglandin EP4 receptor antagonist.1 It produces antihyperalgesic effects in animal models of pain, and has significant...

  • Focus Biomolecules supplier, structure of Prostaglandin E2 | PGE2 | Prostaglandin E (EP) receptor agonist | CAS 363-24-6
    Prostaglandin E2 (363-24-6; PGE2) is an endogenous prostaglandin derived from the action of cyclooxygenase on arachidonic acid. PGE2 has diverse biological actions in the areas of inflammation, cancer, immune modulation,...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Tranilast | NFkB inhibitor | CAS 53902-12-8
    Tranilast (53902-12-8) is an anti-allergy agent (inhibitor of mast cell degranulation) that has been shown to have potent immunomodulatory effects via inhibition of endotoxin induced: PGE2, IC50 = 1-20 μM; TXB2, IC50 =...

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