Toll-like receptors
Showing all 10 results
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Approved Drugs
Allopregnanolone | GABA-A positive allosteric modulator
Allopregnanolone (516-54-1) is an endogenous neurosteroid which acts as a positive allosteric modulator of GABAA receptors.1,2 Recently FDA approve...$70.00 – $280.00 Select options -
New Products
Apilimod | IL-12 and 23/PIKfyve inhibitor
Apilimod (541550-19-0) is a potent (IC50 = 10 nM IFN-g/LPS-stimulated human PMBC’s; IC50 = 1 nM in IFN-g/SAC-stimulated human PMBC’s) IL-12/IL-23 i...$45.00 – $160.00 Select options -
New Products
Imiquimod | TLR7 Agonist
Imiquimod (99011-02-6) is a Toll-like receptor 7/8 agonist with anti-viral and anti-tumor properties.1 Enhances innate immune system leading to Th1...$30.00 – $75.00 Select options -
New Products
L6H21 | MD-2/TLR4 interaction inhibitor
L6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 µM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated c...$55.00 – $180.00 Select options -
Cancer
Loxoribine | TLR7 agonist
Loxoribine (21288-39-9) is a toll-like receptor 7 (TLR7) agonist.1 A potent immunostimulant with a relatively broad spectrum of immunobiological ac...$30.00 – $70.00 Select options -
Cancer
Motolimod | TLR8 agonist
Motolimod (926927-61-9) is a selective Toll-like receptor 8 (TLR8) agonist (EC50 = 100 nM). It stimulates the production of TNFα and IL-12 from mon...$80.00 – $295.00 Select options -
Approved Drugs
Resiquimod | TLR7/8 agonist / Immune adjuvant
Resiquimod (CAS 144875-48-9) is a Toll-like receptor 7/8 agonist.1 May be used as an immune adjuvant in cancer vaccines.2 Resiquimod-carrying synth...$65.00 – $260.00 Select options -
Approved Drugs
Suplatast tosilate | Immunomodulator
Suplatast tosilate (94055-79-2) is a potent immunoregulator that suppresses IgE production.1 Suppresses innate immunity by down-regulating TLR2, TL...$55.00 – $220.00 Select options -
New Products
Vesatolimod | TLR7 agonist/antiviral
Vesatolimod (1228585-88-3) is a Toll-like receptor 7 (TLR7) agonist (EC50 = 290 nM in a HEK293 cell line reporter assay; IFNα MEC 3 nM, 100 fold se...$45.00 – $150.00 Select options -
Cytokines
VGX-1027 | Immunomodulator; Cytokine release inhibitor
VGX-1027 (6501-72-0) is an immunomodulator that inhibits secretion of IL-1β, TNF-α, and IL-10 from murine macrophages stimulated with LPS and spare...$40.00 – $150.00 Select options
