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Infectious Diseases

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  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Apoptolidin | Apoptosis inducer | CAS 194874-06-1
    Apoptolidin (194874-06-1) is a powerful inducer of apoptosis in a variety of cancer cell lines.1 Is believed to act via inhibition of F0F1-ATPase2 but correlation studies indicate that a second mechanism may be the actual...

  • Focus Biomolecules supplier, chemical structure Blasticidin S HCl | Antibiotic selection agent | CAS 3515-03-9
    Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1 Inhibits translation by trapping deformed tRNA on the ribosome.1 The ABC-type transporter NppA1A2BCD...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure Cilastatin Na | Protease inhibitor | CAS 81129-83-1
    Cilastatin Na (81129-83-1) is a dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4 to E4.1  Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus...

  • Ciprofloxacin hydrochloride | Fluoroquinoline antibiotic
    Ciprofloxacin is a clinically useful fluoroquinoline antibiotic. It inhibits bacterial DNA topoisomerase and gyrase with particular effectiveness against gram-negative bacilli bacteria.1,2   References/Citations 1)...

  • Focus Biomolecules reagent supplier, chemical structure Cycloserine, D(+) | NMDA, glycine site partial agonist | CAS 68-41-7
    D-Cycloserine (68-41-7) is a partial agonist at the glycine modulatory site of NMDA glutamatergic receptors.1 Blocks kainate-induced seizures2 and displays anticonvulsant effects3 in rat models. D-Cycloserine facilitates...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Daptomycin | Antibiotic | CAS 103060-53-3
    Daptomycin (103060-53-3) is a cyclic anionic lipopeptide calcium-dependent antibiotic1. Useful for the treatment of serious Gram-positive infections including antibiotic-resistant strains such as MRSA and VRE2...

  • Focus Biomolecules cell signaling tech supplier, chemical structure of Dehydrozingerone | Glutathione sponge | CAS 1080-12-2
    Dehydrozingerone (1080-12-2) is a structural half analog of curcumin (Cat.# 10-1243) and is isolated from ginger rhizomes. Dehydrozingerone displays antioxidant, antibacterial and antifungal properties.1 It has also been...

  • Divin | Divisome assembly inhibitor
    Divin is an iron, cobalt, and copper chelator that arrests the late stages of cytokinesis in bacteria by blocking the physical process of constriction in dividing cells without affecting FtsZ. Iron starvation leads to...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Echinomycin | HIF-1alpha inhibitor | CAS 512-64-1
    Echinomycin (CAS 512-64-1) is a potent and selective hypoxia inducible factor 1α (HIF-1α) inhibitor. It binds to DNA via bifunctional intercalation, blocking the interaction of HIF-1α.1 Protects mice...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Flavopiridol HCl | CDK inhibitor | CAS 131740-09-5
    Flavopiridol HCl (131740-09-5) is a cyclin-dependent kinase (CDK) inhibitor that causes cell cycle arrest at G1 and G2 phase.1 Potentiates (100-200 nM) PMA-induced apoptosis in HL-60 and U937 cells.2 Potentiates the effects...

  • Focus Biomolecules supplier, chemical structure of Hydroxychloroquine sulfate | Autophagy inhibitor | CAS 747-36-4
    Hydroxychloroquine sulfate (747-36-4) is a lysosomotropic agent which inhibits autophagy and triggers apoptosis in a variety of cell types.1,2 Augments the anticancer activity of DNA-damaging chemotherapy...

  • Chemical structure Hypoxanthine
    Hypoxanthine is a natural purine analog and a breakdown product of adenosine.1 Together with aminopterin and thymidine, it is a component of HAT medium2, which is used to select clones during recombinant protein and antibody...

  • IMP-1700 Chemical structure Focus Biomolecules supplier CAS#
    IMP-1700 (1458674-25-3) is a potent inhibitor of the bacterial DNA double-strand break repair complex AddAB. It is capable of synergistic sensitization of methicillin-resistant staphylococcus aureus (MRSA) to...

  • MAC-545496 | GraR inhibitor/Reverses beta-lactam resistance
    MAC-545496 is an inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR). GraR and its regulatory system are important for virulence of S. aureus. MAC-545496 is able to reverse β lactam...

  • Maraviroc | CCR5 Antagonist
    Maraviroc (376348-65-1) is a potent and selective CCR5 antagonist with potent anti-HIV activity. It prevents HIV-1 gp120 binding to CCR5 preventing cell-cell fusion. Maraviroc inhibited MIP-1a (IC50 = 3.3 nM), MIP-1b (IC50 =...

  • Focus Biomolecules supplier, chemical structure of Minocycline HCl | Neuroprotective | Antiapoptotic | CAS 13614-98-7
    Minocycline HCl (13614-98-7) displays antiapoptotic, anti-inflammatory1 activity. Prevents neuropathic pain in a rat sciatic nerve injury model1. Reduces MMP-9 activity2. Attenuates disease severity in mouse models of...

  • Focus Biomolecules cell signaling reagent supplier, chemical structure of Mupirocin | Antibiotic | CAS 12650-69-0
    Mupirocin (12650-69-0) is a topical antibiotic/antibacterial.1 It inhibits isoleucyl-tRNA synthase. High level mupirocin resistance was found in 8.2% of Staphylococcus aureus and 15.6% of coagulase-negative staphylococci...

  • NH125 | Eukaryotic elongation factor 2 (eEF-2) kinase inhibitor
    NH125 (278603-08-0) was originally discovered as an antibacterial agent active against various Gram-positive and -negative bacteria via inhibition of histidine protein kinase.1 It was also found to be a potent inhibitor of...

  • PK150 | Sorafenib analog with unique antibacterial properties
    PK150 (2165324-62-7) is a Sorafenib analog that displays significant antibacterial activity against several pathogenic strains (S.aureus NCTC8325, MIC = 0.3 µM; vancomycin -resistant enterococci, MIC = 3 µM; and...

  • Quinacrine HCl | Antiprotozoan / Anticancer
    Quinacrine HCl (69-05-6) is an antiprotozoan drug used for malaria and giardiasis and has recently been investigated in treating lupus, as an anticancer agent, inflammation, and as a female sterilization agent.1 It has been...

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