my account
Login
  Loading... Please wait...

Inflammation

Acute inflammation is an immune response to a pathogen, irritant, or injury to remove whatever has caused the response, dispose of damaged tissue, and initiate healing. Resident immune cells at the site of insult recognize pathogen-associated molecular patterns (PAMPS) or damage-associated molecular patterns (DAMPS) and release various inflammatory mediators. Initial responses include vasodilation, increased vascular permeability, and extravasation of leukocytes. Mediators of inflammation include bradykinins, the complement system, cytokines, chemokines, leukotrienes, and prostaglandins among others. Chronic inflammation is characterized by infiltration of the tissue site by macrophages and lymphocytes leading to overall tissue damage. Chronic inflammatory diseases include diabetes, cardiovascular diseases, arthritis, allergies, cancer, and chronic obstructive pulmonary disease.

View All Inflammation Reagents

Inflammasome

  • MCC-950

    MCC-950 is an inhibitor of the NLRP3 and AIM2 inflammasome

  • OLT1177

    OLT1177 is a potent and specific inhibitor of the NLRP3 inflammasome

  • Talabostat mesylate

    Non-selective inhibitor of S9 family proteases that activates the NLRP1B inflammasome

View All Inflammasome Reagents

NF-kB

  • Rocaglamide

    Rocaglamide is a potent inhibitor of NF-κB activation

  • Helenalin

    Potent natural product inhibitor of NF-κB

  • DMAPT

    Parthenolide derivative that inhibits NF-κB

View All NF-κB Reagents

COX

  • Rofecoxib

    Rofecoxib is a potent and selective COX-2 inhibitor

  • Oxaprozin

    Clinically useful non-selective COX inhibitor

  • Celecoxib

    Celecoxib is a potent and selective COX-2 inhibitor

View All COX Reagents

Lipoxygenase

  • Zileuton

    Zileuton is a reversible inhibitor of 5-lipoxygenase

  • MK-866

    MK-866 blocks leukotriene biosynthesis via inhibition of FLAP

View All Lipoxygenase Reagents

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus